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Adgre1 adhesion G protein-coupled receptor E1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316137, updated on 2-May-2024

Summary

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Official Symbol
Adgre1provided by RGD
Official Full Name
adhesion G protein-coupled receptor E1provided by RGD
Primary source
RGD:1359214
See related
Ensembl:ENSRNOG00000046254 AllianceGenome:RGD:1359214
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Emr1
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway. Predicted to be located in external side of plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human ADGRE1 (adhesion G protein-coupled receptor E1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 192.2), Liver (RPKM 101.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
9q11
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (2329398..2484959)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (2242476..2398000)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (9431888..9585883, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene SH2 domain containing 3A Neighboring gene vav guanine nucleotide exchange factor 1 Neighboring gene heat shock protein family A (Hsp70) member 14, pseudogene 1 Neighboring gene U1 small nuclear ribonucleoprotein C pseudogene Neighboring gene vomeronasal 2 receptor, pseudogene 140 Neighboring gene vomeronasal 2 receptor, 79

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The EGF-TM7 family of the rat. Hamann J. Immunogenetics, 2004 Dec. PMID 15578266
  2. Molecular cloning of F4/80, a murine macrophage-restricted cell surface glycoprotein with homology to the G-protein-linked transmembrane 7 hormone receptor family. McKnight AJ, et al. J Biol Chem, 1996 Jan 5. PMID 8550607
  3. CLEC4F is an inducible C-type lectin in F4/80-positive cells and is involved in alpha-galactosylceramide presentation in liver. Yang CY, et al. PLoS One, 2013. PMID 23762286, Free PMC Article
  4. Dectin-1 is a major beta-glucan receptor on macrophages. Brown GD, et al. J Exp Med, 2002 Aug 5. PMID 12163569, Free PMC Article
  5. Characterization and identification of subpopulations of mononuclear preosteoclasts induced by TNF-α in combination with TGF-β in rats. Matsubara R, et al. PLoS One, 2012. PMID 23110133, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to transforming growth factor beta stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to tumor necrosis factor IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery ISO
Inferred from Sequence Orthology
more info
  
located_in external side of plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
adhesion G protein-coupled receptor E2
Names
EGF-like module containing, mucin-like, hormone receptor-like sequence 1
EGF-like module receptor 1
EGF-like module-containing mucin-like hormone receptor-like 1
EMR1 hormone receptor
cell surface glycoprotein EMR1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007557.2 → NP_001007558.1  adhesion G protein-coupled receptor E2 precursor

    See identical proteins and their annotated locations for NP_001007558.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q5Y4N8
    UniProtKB/TrEMBL
    A0A8I5ZPM3, A6KQQ5
    Related
    ENSRNOP00000067220.1, ENSRNOT00000073926.3
    Conserved Domains (6) summary
    smart00303
    Location:592 → 641
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:33 → 63
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam00002
    Location:646 → 886
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam07645
    Location:319 → 359
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:245 → 275
    cEGF; Complement Clr-like EGF-like

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    2329398..2484959
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244280.5 → XP_006244342.1  adhesion G protein-coupled receptor E2 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZPM3, A0A8I5ZYF2
    Related
    ENSRNOP00000084080.1
    Conserved Domains (6) summary
    smart00303
    Location:592 → 641
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:33 → 63
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:319 → 359
    EGF_CA; Calcium-binding EGF domain
    pfam12662
    Location:245 → 275
    cEGF; Complement Clr-like EGF-like
    cl21561
    Location:637 → 821
    7tm_4; Olfactory receptor

  2. XM_039083468.2 → XP_038939396.1  adhesion G protein-coupled receptor E2 isoform X3

    Conserved Domains (6) summary
    smart00303
    Location:592 → 641
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:133 → 172
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:33 → 63
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam12662
    Location:245 → 275
    cEGF; Complement Clr-like EGF-like
    cd14964
    Location:647 → 672
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:645 → 709
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  3. XM_039083467.2 → XP_038939395.1  adhesion G protein-coupled receptor E2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZPM3
    Conserved Domains (6) summary
    smart00303
    Location:571 → 620
    GPS; G-protein-coupled receptor proteolytic site domain
    smart00179
    Location:112 → 151
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:12 → 42
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    pfam07645
    Location:298 → 338
    EGF_CA; Calcium-binding EGF domain
    cd15439
    Location:624 → 886
    7tmB2_EMR; epidermal growth factor-like module-containing mucin-like hormone receptors, member of the class B2 family of seven-transmembrane G protein-coupled receptors
    pfam12662
    Location:224 → 254
    cEGF; Complement Clr-like EGF-like
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5Y4N8.1 GenPept UniProtKB/Swiss-Prot:Q5Y4N8

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