U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Azi2 5-azacytidine induced 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 316051, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Azi2provided by RGD
Official Full Name
5-azacytidine induced 2provided by RGD
Primary source
RGD:1310530
See related
Ensembl:ENSRNOG00000010096 AllianceGenome:RGD:1310530
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be involved in I-kappaB kinase/NF-kappaB signaling. Predicted to act upstream of or within several processes, including T cell activation; dendritic cell differentiation; and dendritic cell proliferation. Predicted to be active in cytoplasm. Orthologous to human AZI2 (5-azacytidine induced 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 87.6), Heart (RPKM 87.6) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Azi2 in Genome Data Viewer
Location:
8q32
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (126651268..126674795)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (117773248..117797844)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (126411030..126435581)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120093118 Neighboring gene uncharacterized LOC134480246 Neighboring gene uncharacterized LOC120094353 Neighboring gene zinc finger CW-type and PWWP domain containing 2 Neighboring gene C-x(9)-C motif containing 1 Neighboring gene uncharacterized LOC120094354 Neighboring gene uncharacterized LOC108351794

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival. Maruyama K, et al. J Biol Chem, 2015 Apr 10. PMID 25691576, Free PMC Article
  2. Isolation of the novel cDNA of a gene of which expression is induced by a demethylating stimulus. Miyagawa J, et al. Gene, 1999 Nov 29. PMID 10580148
  3. Brain formation of oestrogen in the mouse: sex dimorphism in aromatase development. Hutchison JB, et al. J Steroid Biochem Mol Biol, 1994 Jun. PMID 8043507
  4. Critical role of AZI2 in GM-CSF-induced dendritic cell differentiation. Fukasaka M, et al. J Immunol, 2013 Jun 1. PMID 23610142
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that 5-Azacytidine-induced protein 2 (AZI2) deficiency mice Are osteoporotic.
    Title: 5-Azacytidine-induced protein 2 (AZI2) regulates bone mass by fine-tuning osteoclast survival.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC112644

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in T cell activation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within T cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendritic cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in dendritic cell proliferation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within dendritic cell proliferation ISO
Inferred from Sequence Orthology
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
5-azacytidine-induced protein 2
Names
5-azacytidine induced gene 2

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025705.1 → NP_001020876.1  5-azacytidine-induced protein 2

    See identical proteins and their annotated locations for NP_001020876.1

    Status: PROVISIONAL

    Source sequence(s)
    BC098680
    UniProtKB/Swiss-Prot
    Q4KMA0
    Conserved Domains (2) summary
    pfam05615
    Location:115 → 219
    THOC7; Tho complex subunit 7
    pfam12845
    Location:229 → 277
    TBD; TBD domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    126651268..126674795
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006244032.5 → XP_006244094.1  5-azacytidine-induced protein 2 isoform X1

    UniProtKB/TrEMBL
    F1LQL4
    Related
    ENSRNOP00000013449.7
    Conserved Domains (2) summary
    pfam05615
    Location:115 → 219
    THOC7; Tho complex subunit 7
    pfam12845
    Location:229 → 277
    TBD; TBD domain

  2. XM_063265650.1 → XP_063121720.1  5-azacytidine-induced protein 2 isoform X1

    UniProtKB/TrEMBL
    F1LQL4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KMA0.1 GenPept UniProtKB/Swiss-Prot:Q4KMA0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous