Csk C-terminal Src kinase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cskprovided by RGD
Official Full Name: C-terminal Src kinaseprovided by RGD
Primary source: RGD:1308800
See related: Ensembl:ENSRNOG00000019374 AllianceGenome:RGD:1308800
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables proline-rich region binding activity; protein phosphatase binding activity; and protein tyrosine kinase activity. Involved in several processes, including central nervous system development; negative regulation of bone resorption; and regulation of MAPK cascade. Located in cytoplasm and membrane raft. Biomarker of hepatocellular carcinoma. Orthologous to human CSK (C-terminal Src kinase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 284.1), Thymus (RPKM 181.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q24

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (66925650..66944861, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (58029748..58048742, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (62405714..62424707, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

recruitment of Csk and PTEN to the region between residues 266 and 283 within the C-terminus of Cx43 leads to c-Src inhibition in glioma cells and astrocytes
Title: Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
Ang II increased Csk expression and induced podocyte apoptosis, stimulated Csk translocation and binding to Caveolin-1.
Title: Csk regulates angiotensin II-induced podocyte apoptosis.
an allosteric connection between Cbp binding and Csk activation that arises from residues in the betaB/betaC loop of the SH2 domain.
Title: Identification of a new interaction mode between the Src homology 2 domain of C-terminal Src kinase (Csk) and Csk-binding protein/phosphoprotein associated with glycosphingolipid microdomains.
Recognition of Src-family kinases (SFKs) by Csk is mainly governed by interactions between motifs located distally from the active site of Csk and determinants spatially separate from the carboxyl-terminal regulatory tyrosine residue in SFKs.
Title: Defining the substrate specificity determinants recognized by the active site of C-terminal Src kinase-homologous kinase (CHK) and identification of β-synuclein as a potential CHK physiological substrate.
Neph1 but not nephrin specifically binds to adaptor protein Grb2 and tyrosine kinase Csk in a phosphorylation-dependent manner.
Title: Neph1, a component of the kidney slit diaphragm, is tyrosine-phosphorylated by the Src family tyrosine kinase and modulates intracellular signaling by binding to Grb2.
These results suggest novel roles for ZO proteins as Src/Csk scaffolds potentially involved in the regulation of Src transformation.
Title: Proteomic identification of ZO-1/2 as a novel scaffold for Src/Csk regulatory circuit.
Adrenomedullin attenuates the angiotensin II-induced increase in reactive oxygen species in vascular smooth muscle cells via activation of Csk, thereby inhibiting Src activity
Title: Adrenomedullin inhibits angiotensin II-induced oxidative stress via Csk-mediated inhibition of Src activity.
A series of 5,7-disubstituted quinazolines, bearing 4-heteroaryl substituents such as 2-pyridinylamine or 2-pyrazinylamine, has been synthetised and evaluated as c-Src kinase inhibitors
Title: New heterocyclic analogues of 4-(2-chloro-5-methoxyanilino)quinazolines as potent and selective c-Src kinase inhibitors.
elucidation of molecular structure to determine regulation of Src family tyrosine kinases
Title: Structure of the carboxyl-terminal Src kinase, Csk.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Csk (e-PCR), detects polymorphism
- UniSTS:480304

Csk (e-PCR), detects polymorphism
- UniSTS:527296

AW212630 (e-PCR)
- UniSTS:179906

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables non-membrane spanning protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables proline-rich region binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein phosphatase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein tyrosine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in adaptive immune response	IEA Inferred from Electronic Annotation more info
involved_in adherens junction organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in adherens junction organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to peptide hormone stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of Golgi to plasma membrane protein transport	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of bone resorption	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-6 production	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of low-density lipoprotein particle clearance	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of phagocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in oligodendrocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of Fc receptor mediated stimulatory signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein kinase CSK

Names: C-SRC kinase; CSK, non-receptor tyrosine kinase; c-src tyrosine kinase; protein-tyrosine kinase (CSK)

NP_001025210.1

EC 2.7.10.2

XP_006243225.1

EC 2.7.10.2

XP_006243226.1

EC 2.7.10.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001030039.1 → NP_001025210.1 tyrosine-protein kinase CSK

See identical proteins and their annotated locations for NP_001025210.1

Status: PROVISIONAL

Source sequence(s)

BC098863

UniProtKB/Swiss-Prot

P32577, Q4G003

UniProtKB/TrEMBL

A0A8L2QZY0, A6J4X1

Related

ENSRNOP00000026358.5, ENSRNOT00000026358.7

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

66925650..66944861 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006243163.3 → XP_006243225.1 tyrosine-protein kinase CSK isoform X1

See identical proteins and their annotated locations for XP_006243225.1

UniProtKB/Swiss-Prot

P32577, Q4G003

UniProtKB/TrEMBL

A0A8L2QZY0, A6J4X1

Related

ENSRNOP00000068638.2

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase
XM_006243164.5 → XP_006243226.1 tyrosine-protein kinase CSK isoform X1

See identical proteins and their annotated locations for XP_006243226.1

UniProtKB/Swiss-Prot

P32577, Q4G003

UniProtKB/TrEMBL

A0A8L2QZY0, A6J4X1

Conserved Domains (3) summary

cd05082
Location:188 → 443

PTKc_Csk; Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase

cd09937
Location:78 → 175

SH2_csk_like; Src homology 2 (SH2) domain found in Carboxyl-Terminal Src Kinase (Csk)

cd11769
Location:11 → 67

SH3_CSK; Src Homology 3 domain of C-terminal Src kinase