Itga5 integrin subunit alpha 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga5provided by RGD
Official Full Name: integrin subunit alpha 5provided by RGD
Primary source: RGD:2925
See related: Ensembl:ENSRNOG00000057451 AllianceGenome:RGD:2925
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Itga5_retired
Summary: Enables epidermal growth factor receptor binding activity and integrin binding activity. Involved in several processes, including female pregnancy; integrin-mediated signaling pathway; and positive regulation of cell-substrate adhesion. Located in cytoplasm. Part of integrin complex. Orthologous to human ITGA5 (integrin subunit alpha 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 171.8), Lung (RPKM 113.5) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q36

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (136358097..136381305, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (134478963..134502837, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (144970444..144993652, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Delayed notochordal cell disappearance through integrin alpha5beta1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.
Title: Delayed notochordal cell disappearance through integrin α5β1 mechanotransduction during ex-vivo dynamic loading-induced intervertebral disc degeneration.
Integrin alphanubeta3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells.
Title: Integrin ανβ3 modulates lipopolysaccharide-induced hyperpermeability in cardiac microvascular endothelial cells.
Titanium with nanotopography induces osteoblast differentiation through regulation of integrin alphaV.
Title: Titanium with nanotopography induces osteoblast differentiation through regulation of integrin αV.
These results indicate that integrin alpha5beta1 expression on dopaminergic neurons plays an important role in the dopaminergic neurite outgrowth on striatal neurons.
Title: Integrin α5β1 expression on dopaminergic neurons is involved in dopaminergic neurite outgrowth on striatal neurons.
Transduction of rat bone marrow mesenchymal stem cells with ITGA5B1 lentivirus could prevent cell anoikis and increase nitric oxide production.
Title: Integrin alpha5beta1 suppresses rBMSCs anoikis and promotes nitric oxide production.
alpha 5 integrin promotes brain metastases in cancer cells and may mediate early steps in the metastatic cascade, such as adhesion to brain vasculature. Targeting alphav integrin with intetumumab could provide clinical benefit in treating cancer patients who develop metastases.
Title: High αv Integrin Level of Cancer Cells Is Associated with Development of Brain Metastasis in Athymic Rats.
This is the first study to detail the signaling pathway triggered by alphavbeta3, the endogenous Thy-1 ligand, highlighting the role of membrane-bound integrins as trans acting ligands in astrocyte-neuron communication
Title: Astrocyte-to-neuron communication through integrin-engaged Thy-1/CBP/Csk/Src complex triggers neurite retraction via the RhoA/ROCK pathway.
The membrane fraction of diabetic-derived fibroblasts showed a decrease of integrin subunits alpha5 and alphav, which was confirmed by immunocytochemistry assays.
Title: Hyperglycemia reduces integrin subunits alpha v and alpha 5 on the surface of dermal fibroblasts contributing to deficient migration.
this study shows that experimental iabetes interferes with the osseointegration of implants by deferring expression of fibronectin and integrin alpha5beta1
Title: Potential mechanism for osseointegration of dental implants in Zucker diabetic fatty rats.
Data indicate that estradiol-induced activation of integrin alpha5beta1 accelerates behavioral recovery of 6-OHDA-esioned hemi-Parkinsonian model.
Title: Estradiol Facilitates Functional Integration of iPSC-Derived Dopaminergic Neurons into Striatal Neuronal Circuits via Activation of Integrin α5β1.

Submit: New GeneRIF Correction See all GeneRIFs (34)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Itga5 (e-PCR), detects polymorphism
- UniSTS:143619

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables cell adhesion molecule binding	IDA Inferred from Direct Assay more info	PubMed
enables epidermal growth factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables integrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in CD40 signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in angiogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-substrate adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell-substrate junction assembly	ISO Inferred from Sequence Orthology more info
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in female pregnancy	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in integrin-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in integrin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within memory	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of anoikis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cell-substrate adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-tyrosine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in wound healing, spreading of epidermal cells	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	TAS Traceable Author Statement more info	PubMed
located_in focal adhesion	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha5-beta1 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of integrin complex	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
is_active_in postsynaptic membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info
located_in synapse	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-5

Names: integrin alpha 5 (fibronectin receptor alpha); integrin, alpha 5 (fibronectin receptor, alpha polypeptide)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108118.1 → NP_001101588.1 integrin alpha-5

See identical proteins and their annotated locations for NP_001101588.1

Status: PROVISIONAL

Source sequence(s)

CH474035

UniProtKB/TrEMBL

A0A8I5YCC9, A6KD08

Related

ENSRNOP00000077413.1, ENSRNOT00000115763.1

Conserved Domains (2) summary

smart00191
Location:438 → 492

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:539 → 971

Integrin_alpha2; Integrin alpha

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

136358097..136381305 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079352.2 → XP_038935280.1 integrin alpha-5 isoform X3

UniProtKB/TrEMBL

A0A8I5YCC9

Conserved Domains (2) summary

smart00191
Location:438 → 492

Int_alpha; Integrin alpha (beta-propellor repeats)

pfam08441
Location:539 → 971

Integrin_alpha2; Integrin alpha
XM_063263685.1 → XP_063119755.1 integrin alpha-5 isoform X2
XM_063263684.1 → XP_063119754.1 integrin alpha-5 isoform X1