Wnt7b Wnt family member 7B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Wnt7bprovided by RGD
Official Full Name: Wnt family member 7Bprovided by RGD
Primary source: RGD:1311441
See related: Ensembl:ENSRNOG00000015750 AllianceGenome:RGD:1311441
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chemoattractant activity involved in axon guidance; cytokine activity; and frizzled binding activity. Involved in several processes, including positive regulation of JNK cascade; regulation of cell projection size; and response to glucocorticoid. Located in cytoplasm; extracellular space; and plasma membrane. Orthologous to human WNT7B (Wnt family member 7B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 45.1), Kidney (RPKM 38.4) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (118514684..118559316, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (116634817..116679459, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (126423418..126465724, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/beta-catenin pathway.
Title: LncRNA OIP5-AS1/miR-410-3p/Wnt7b axis promotes the proliferation of rheumatoid arthritis fibroblast-like synoviocytes via regulating the Wnt/β-catenin pathway.
Klotho/FGF23 axis mediates high phosphate-induced vascular calcification in vascular smooth muscle cells via Wnt7b/beta-catenin pathway.
Title: Klotho/FGF23 axis mediates high phosphate-induced vascular calcification in vascular smooth muscle cells via Wnt7b/β-catenin pathway.
Wnt7b/beta-catenin signaling may play an important role infetal rat alveolar epithelial type II cells (fAEC2) transdifferentiation.
Title: [The changes of Wnt7b/β-catenin signaling pathway molecules in the differentiation of fetal alveolar epithelial type II cells].
analysis of downregulation of Mig-6, Wnt-7b, and Wnt-9a during osteoarthritis; Wnt-7b is expressed also in osteoblast-like cells
Title: Expression of MIG-6, WNT-9A, and WNT-7B during osteoarthritis.

Submit: New GeneRIF Correction

General gene information

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Markers

Wnt7b (e-PCR), detects polymorphism
- UniSTS:508424

Wnt7b (e-PCR), detects polymorphism
- UniSTS:465426

Wnt7b (e-PCR), detects polymorphism
- UniSTS:526102

D7Rat97 (e-PCR)
- UniSTS:119071

Wnt7b (e-PCR), detects polymorphism
- UniSTS:471330

D7Rat60 (e-PCR), detects polymorphism
- UniSTS:228187

Wnt7b (e-PCR), detects polymorphism
- UniSTS:277888

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chemoattractant activity involved in axon guidance	ISO Inferred from Sequence Orthology more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within anatomical structure regression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within apoptotic process involved in blood vessel morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell proliferation in forebrain	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within central nervous system vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in chemoattraction of dopaminergic neuron axon	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chorio-allantoic fusion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within developmental growth involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic organ development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic placenta morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment or maintenance of polarity of embryonic epithelium	ISO Inferred from Sequence Orthology more info
involved_in fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in forebrain regionalization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within homeostatic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner medullary collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within intracellular oxygen homeostasis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lobar bronchus development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung-associated mesenchyme development	ISO Inferred from Sequence Orthology more info
involved_in mammary gland epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephric collecting duct development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephric epithelium development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephric loop of Henle development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within metanephros morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neurogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection morphogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within odontogenesis of dentin-containing tooth	ISO Inferred from Sequence Orthology more info
acts_upstream_of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outer medullary collecting duct development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell projection size	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within renal inner medulla development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within renal outer medulla development	ISO Inferred from Sequence Orthology more info
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within smooth muscle cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in stem cell development	ISO Inferred from Sequence Orthology more info
involved_in stem cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within synapse organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within trachea cartilage morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vasculature development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein Wnt-7b

Names: wingless-related MMTV integration site 7B; wingless-type MMTV integration site family, member 7B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009695.2 → NP_001009695.1 protein Wnt-7b isoform 1

See identical proteins and their annotated locations for NP_001009695.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

Q5NSW6

Related

ENSRNOP00000093131.1, ENSRNOT00000108799.1

Conserved Domains (1) summary

cd19350
Location:32 → 349

wnt_Wnt7b; Wnt domain found in protein Wnt-7b and similar proteins
NM_001412610.1 → NP_001399539.1 protein Wnt-7b isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000007

UniProtKB/TrEMBL

A0A0G2K3B7

Related

ENSRNOP00000072573.1, ENSRNOT00000081032.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

118514684..118559316 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039079298.1 → XP_038935226.1 protein Wnt-7b isoform X1

Conserved Domains (1) summary

cl38924
Location:28 → 276

Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family