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Zhx2 zinc fingers and homeoboxes 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314988, updated on 3-Apr-2024

Summary

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Official Symbol
Zhx2provided by RGD
Official Full Name
zinc fingers and homeoboxes 2provided by RGD
Primary source
RGD:727926
See related
Ensembl:ENSRNOG00000005417 AllianceGenome:RGD:727926
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; protein heterodimerization activity; and protein homodimerization activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II and retinal bipolar neuron differentiation. Predicted to act upstream of or within mRNA catabolic process; negative regulation of neuron differentiation; and somatic stem cell population maintenance. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Orthologous to human ZHX2 (zinc fingers and homeoboxes 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 82.0), Kidney (RPKM 75.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q33
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (91115894..91263823)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (89226358..89374266)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (97559653..97707872)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479733 Neighboring gene uncharacterized LOC134479734 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC102553568 Neighboring gene ribosomal protein L37A, pseudogene 14 Neighboring gene derlin 1 Neighboring gene TBC1 domain family, member 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The alpha-fetoprotein promoter is the target of Afr1-mediated postnatal repression. Peyton DK, et al. Genomics, 2000 Jan 15. PMID 10673330
  2. raf regulates the postnatal repression of the mouse alpha-fetoprotein gene at the posttranscriptional level. Vacher J, et al. Mol Cell Biol, 1992 Feb. PMID 1370712, Free PMC Article
  3. Zinc-fingers and homeoboxes (ZHX) 2, a novel member of the ZHX family, functions as a transcriptional repressor. Kawata H, et al. Biochem J, 2003 Aug 1. PMID 12741956, Free PMC Article
  4. Mouse alpha-fetoprotein gene 5' regulatory elements are required for postnatal regulation by raf and Rif. Spear BT. Mol Cell Biol, 1994 Oct. PMID 7523852, Free PMC Article
  5. The role of Zhx2 transcription factor in bipolar cell differentiation during mouse retinal development. Kawamura Y, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30146259

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein heterodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein heterodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within mRNA catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in retinal bipolar neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within somatic stem cell population maintenance ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
zinc fingers and homeoboxes protein 2
Names
AFP regulator 1
alpha-fetoprotein regulator 1
regulator of AFP
transcription factor ZHX2
zinc finger and homeodomain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001271056.1 → NP_001257985.1  zinc fingers and homeoboxes protein 2

    See identical proteins and their annotated locations for NP_001257985.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000007
    UniProtKB/Swiss-Prot
    G3V6P3, Q80VX4
    Related
    ENSRNOP00000095233.1, ENSRNOT00000099915.1
    Conserved Domains (3) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam18387
    Location:106 → 158
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    91115894..91263823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006241654.5 → XP_006241716.1  zinc fingers and homeoboxes protein 2 isoform X1

    See identical proteins and their annotated locations for XP_006241716.1

    UniProtKB/Swiss-Prot
    G3V6P3, Q80VX4
    Related
    ENSRNOP00000092484.1
    Conserved Domains (3) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam18387
    Location:106 → 158
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  2. XM_017594857.3 → XP_017450346.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    G3V6P3, Q80VX4
    Related
    ENSRNOP00000007326.4
    Conserved Domains (3) summary
    smart00389
    Location:537 → 582
    HOX; Homeodomain
    cd00086
    Location:444 → 496
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam18387
    Location:106 → 158
    zf_C2H2_ZHX; Zinc-fingers and homeoboxes C2H2 finger domain

  3. XM_063263558.1 → XP_063119628.1  zinc fingers and homeoboxes protein 2 isoform X1

    UniProtKB/Swiss-Prot
    G3V6P3, Q80VX4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80VX4.2 GenPept UniProtKB/Swiss-Prot:Q80VX4

Gene LinkOut

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