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Pip5k1c phosphatidylinositol-4-phosphate 5-kinase type 1 gamma [ Rattus norvegicus (Norway rat) ]

Gene ID: 314641, updated on 11-Apr-2024

Summary

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Official Symbol
Pip5k1cprovided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase type 1 gammaprovided by RGD
Primary source
RGD:1309938
See related
Ensembl:ENSRNOG00000020577 AllianceGenome:RGD:1309938
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity and talin binding activity. Predicted to be involved in regulation of postsynaptic neurotransmitter receptor internalization and regulation of synaptic vesicle endocytosis. Predicted to act upstream of or within axonogenesis; phosphatidylinositol biosynthetic process; and platelet aggregation. Is active in presynaptic endocytic zone membrane. Human ortholog(s) of this gene implicated in lethal congenital contracture syndrome 3. Orthologous to human PIP5K1C (phosphatidylinositol-4-phosphate 5-kinase type 1 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 213.4), Spleen (RPKM 93.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
7q11
Exon count:
19
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (9048135..9076751, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (8397406..8426030, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (11267207..11294291, complement)

Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene thromboxane A2 receptor Neighboring gene cactin, spliceosome C complex subunit Neighboring gene tight junction protein 3 Neighboring gene amyloid beta precursor protein binding family A member 3 Neighboring gene mitochondrial ribosomal protein L54

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol phosphate kinases. Giudici ML, et al. J Endocrinol Invest, 2004. PMID 15481814
  2. NMDA receptor-mediated PIP5K activation to produce PI(4,5)P₂ is essential for AMPA receptor endocytosis during LTD. Unoki T, et al. Neuron, 2012 Jan 12. PMID 22243752
  3. Impaired PtdIns(4,5)P2 synthesis in nerve terminals produces defects in synaptic vesicle trafficking. Di Paolo G, et al. Nature, 2004 Sep 23. PMID 15386003
  4. A novel neuronal-specific splice variant of Type I phosphatidylinositol 4-phosphate 5-kinase isoform gamma. Giudici ML, et al. Biochem J, 2004 Apr 15. PMID 14741049, Free PMC Article
  5. PIP kinase Igamma is the major PI(4,5)P(2) synthesizing enzyme at the synapse. Wenk MR, et al. Neuron, 2001 Oct 11. PMID 11604140

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC124518

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables talin binding ISO
Inferred from Sequence Orthology
more info
  
enables talin binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within axonogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
  
involved_in exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within platelet aggregation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic neurotransmitter receptor internalization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in adherens junction IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in endosome membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endosome membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in phagocytic cup IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic density ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic endocytic zone membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  
located_in uropod IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 gamma
Names
PIP5K1-gamma
PIP5KIgamma
phosphatidylinositol 4-phosphate 5-kinase type I gamma
ptdIns(4)P-5-kinase 1 gamma
ptdIns(4)P-5-kinase gamma
ptdInsPKIgamma
NP_001009967.2
NP_001029142.1
XP_006240997.1
XP_008763323.1
XP_008763325.1
XP_038934948.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009967.2 → NP_001009967.2  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform c

    Status: PROVISIONAL

    Source sequence(s)
    AY850259, BC101909, CB557931, CB581409, CB696331, CK366332
    UniProtKB/TrEMBL
    F1M8H6
    Related
    ENSRNOP00000057873.2, ENSRNOT00000061159.5
    Conserved Domains (1) summary
    smart00330
    Location:103 → 443
    PIPKc; Phosphatidylinositol phosphate kinases

  2. NM_001033970.1 → NP_001029142.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform b

    See identical proteins and their annotated locations for NP_001029142.1

    Status: PROVISIONAL

    Source sequence(s)
    AY850259, BC101909, CB557931, CB696331, CK366332
    UniProtKB/TrEMBL
    A0A8I5XWP7, Q3MID5
    Related
    ENSRNOP00000086276.1, ENSRNOT00000095691.1
    Conserved Domains (1) summary
    smart00330
    Location:103 → 443
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086025.1 Reference GRCr8

    Range
    9048135..9076751 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008765103.4 → XP_008763325.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X3

    UniProtKB/TrEMBL
    F1M8H6
    Conserved Domains (1) summary
    smart00330
    Location:103 → 443
    PIPKc; Phosphatidylinositol phosphate kinases

  2. XM_039079020.2 → XP_038934948.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X2

    UniProtKB/TrEMBL
    F1M8H6
    Conserved Domains (1) summary
    cd17308
    Location:76 → 449
    PIPKc_PIP5K1C; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 gamma (PIP5K1gamma) and similar proteins

  3. XM_008765101.4 → XP_008763323.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X1

    UniProtKB/TrEMBL
    F1M8H6
    Conserved Domains (1) summary
    smart00330
    Location:103 → 443
    PIPKc; Phosphatidylinositol phosphate kinases

  4. XM_006240935.5 → XP_006240997.1  phosphatidylinositol 4-phosphate 5-kinase type-1 gamma isoform X4

    UniProtKB/TrEMBL
    F1M8H6
    Related
    ENSRNOP00000097462.1
    Conserved Domains (1) summary
    smart00330
    Location:103 → 443
    PIPKc; Phosphatidylinositol phosphate kinases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5I6B8.1 GenPept UniProtKB/Swiss-Prot:Q5I6B8

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