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Gpr132 G protein-coupled receptor 132 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314480, updated on 13-Apr-2024

Summary

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Official Symbol
Gpr132provided by RGD
Official Full Name
G protein-coupled receptor 132provided by RGD
Primary source
RGD:1310817
See related
Ensembl:ENSRNOG00000013914 AllianceGenome:RGD:1310817
Gene type
protein coding
RefSeq status
INFERRED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
G2a
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G1/S transition of mitotic cell cycle and negative regulation of G2/M transition of mitotic cell cycle. Predicted to be integral component of membrane. Orthologous to human GPR132 (G protein-coupled receptor 132). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 81.1), Spleen (RPKM 54.9) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (137745142..137763037, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (131924061..131943327, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (137652213..137671658, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene clathrin binding box of aftiphilin containing 1 Neighboring gene cell division cycle associated 4 Neighboring gene keratin-associated protein 5-9-like Neighboring gene jagged canonical Notch ligand 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A DNA damage and stress inducible G protein-coupled receptor blocks cells in G2/M. Weng Z, et al. Proc Natl Acad Sci U S A, 1998 Oct 13. PMID 9770487, Free PMC Article
  2. Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. Ikeno Y, et al. J Biol Chem, 2005 Jul 29. PMID 15927955
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The neuritogenic effect of sPLA2 is mediated by generation of LPC and subsequent activation of G2a (G protein-coupled receptor 132).
    Title: Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
probable G-protein coupled receptor 132
Names
G protein-coupled receptor G2a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001170595.1 → NP_001164066.1  probable G-protein coupled receptor 132

    See identical proteins and their annotated locations for NP_001164066.1

    Status: INFERRED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6AM45, A6KBW8, D3ZIH1
    Related
    ENSRNOP00000018613.3, ENSRNOT00000018613.4
    Conserved Domains (2) summary
    cd14964
    Location:72 → 97
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 315
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    137745142..137763037 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017594191.3 → XP_017449680.1  probable G-protein coupled receptor 132 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AM45, A6KBW8, D3ZIH1
    Conserved Domains (2) summary
    cd14964
    Location:72 → 97
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 315
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  2. XM_006240661.5 → XP_006240723.1  probable G-protein coupled receptor 132 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A964, A0A8I6AM45
    Related
    ENSRNOP00000087645.1
    Conserved Domains (1) summary
    pfam00001
    Location:146 → 395
    7tm_1; 7 transmembrane receptor (rhodopsin family)

  3. XM_039112425.2 → XP_038968353.1  probable G-protein coupled receptor 132 isoform X2

    UniProtKB/TrEMBL
    A0A8I6AM45, A6KBW8, D3ZIH1
    Conserved Domains (2) summary
    cd14964
    Location:72 → 97
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:48 → 315
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  4. XM_039112426.2 → XP_038968354.1  probable G-protein coupled receptor 132 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM45
    Conserved Domains (2) summary
    cd14964
    Location:24 → 49
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:2 → 267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

  5. XM_039112427.1 → XP_038968355.1  probable G-protein coupled receptor 132 isoform X3

    UniProtKB/TrEMBL
    A0A8I6AM45
    Conserved Domains (2) summary
    cd14964
    Location:24 → 49
    7tm_GPCRs; TM helix 2 [structural motif]
    cl28897
    Location:2 → 267
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version

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