Elk1 ETS transcription factor ELK1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Elk1provided by RGD
Official Full Name: ETS transcription factor ELK1provided by RGD
Primary source: RGD:1598663
See related: Ensembl:ENSRNOG00000010171 AllianceGenome:RGD:1598663
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. Multiple isoforms are produced from this gene by the use of alternative translational start codons. [provided by RefSeq, Mar 2012]
Expression: Biased expression in Heart (RPKM 88.7), Muscle (RPKM 76.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: Xq11

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	X	NC_086039.1 (3692367..3709252)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	X	NC_051356.1 (1138826..1155713)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	X	NC_005120.4 (1287875..1304822)

Chromosome X - NC_086039.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Elk1 suppression protects cortical neurons against oxygen-glucose deprivation injury.
Title: ETS-domain containing protein (Elk1) suppression protects cortical neurons against oxygen-glucose deprivation injury.
insulin activates prolactin gene transcription by activating Elk-1 that recruits the NuA4 complex to the promoter.
Title: Insulin-activated Elk-1 recruits the TIP60/NuA4 complex to increase prolactin gene transcription.
The CentA1-Ras-Elk-1 signaling pathway acts on mitochondria to regulate dendritic spine density and synaptic plasticity in response to Abeta in hippocampal neurons.
Title: Centaurin-α1-Ras-Elk-1 signaling at mitochondria mediates β-amyloid-induced synaptic dysfunction.
Morphine activates ELK-1 via ERK-1/2 in DRG-derived F11 cells endogenously expressing mu and delta ORs.
Title: Morphine activates the E twenty six-like transcription factor-1/serum response factor pathway via extracellular signal-regulated kinases 1/2 in F11 cells derived from dorsal root ganglia neurons.
Deactivation of NR2B attenuates Elk-1 expression in learning and memory related regions.
Title: [NR2B-pERK1/2-pElk-1 signaling contributes to the avoidance learning and memory of rats].
to suppress transcription, Elk-1 binds with histone deacetylases and thereby contributes to the inactive chromatin state in E1A + cHa-ras cells.
Title: [Transformation with the E1A + cHa-ras oncogenes enhances the trans-repressor function of the Elk-1 transcription factor].
mGluR5-mediated Elk-1 phosphorylation facilitates gene transcription in striatal neurons via multiple signaling mechanisms involving Ca2+ release and NMDA activation
Title: Metabotropic glutamate receptor 5-regulated Elk-1 phosphorylation and immediate early gene expression in striatal neurons.
Elk-1 regulates telokin expression
Title: Smooth muscle-specific genes are differentially sensitive to inhibition by Elk-1.
PARP-1 activation enhanced ERK2-induced Elk1-phosphorylation, core histone acetylation, and transcription of the Elk1-target gene c-fos.
Title: DNA-independent PARP-1 activation by phosphorylated ERK2 increases Elk1 activity: a link to histone acetylation.
ERK-1/-2 and p38 MAPK activities modulate Elk-1 expression and activation to regulate skeletal muscle differentiation
Title: Involvement of Elk-1 in L6E9 skeletal muscle differentiation.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH142956 (e-PCR)
- UniSTS:232203

Elk1 (e-PCR), detects polymorphism
- UniSTS:546753

RH140607 (e-PCR)
- UniSTS:222676

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables nuclear receptor coactivator activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to gamma radiation	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to lipid	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to testosterone stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in hippocampal neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within liver development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lung development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to fibroblast growth factor	IDA Inferred from Direct Assay more info	PubMed
involved_in response to light stimulus	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in axon terminus	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial membrane	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ETS domain-containing protein Elk-1

Names: ELK1, ETS transcription factor; ELK1, member of ETS oncogene family

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001108059.3 → NP_001101529.1 ETS domain-containing protein Elk-1

See identical proteins and their annotated locations for NP_001101529.1

Status: REVIEWED

Source sequence(s)

FM043339, JAXUCZ010000021

UniProtKB/Swiss-Prot

A4GTP4

UniProtKB/TrEMBL

A0A8I6A3K1

Related

ENSRNOP00000013522.3, ENSRNOT00000013522.6

Conserved Domains (3) summary

smart00413
Location:4 → 89

ETS; erythroblast transformation specific domain

PHA03132
Location:112 → 246

PHA03132; thymidine kinase; Provisional

PHA03247
Location:100 → 427

PHA03247; large tegument protein UL36; Provisional

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086039.1 Reference GRCr8

Range

3692367..3709252

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006256614.3 → XP_006256676.1 ETS domain-containing protein Elk-1 isoform X1

See identical proteins and their annotated locations for XP_006256676.1

UniProtKB/Swiss-Prot

A4GTP4

UniProtKB/TrEMBL

A0A8I6A3K1

Conserved Domains (3) summary

smart00413
Location:4 → 89

ETS; erythroblast transformation specific domain

PHA03132
Location:112 → 246

PHA03132; thymidine kinase; Provisional

PHA03247
Location:100 → 427

PHA03247; large tegument protein UL36; Provisional
XM_063280007.1 → XP_063136077.1 ETS domain-containing protein Elk-1 isoform X2