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snf sans fille [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31442, updated on 10-May-2024

Summary

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Official Symbol
snfprovided by FlyBase
Official Full Name
sans filleprovided by FlyBase
Primary source
FLYBASE:FBgn0003449
Locus tag
Dmel_CG4528
See related
AllianceGenome:FB:FBgn0003449
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG4528; D25; Dmel\CG4528; dSNF; fs(1)1621; fs(1)A16121; fs(1)A1621; liz; Snf; SNF; SNF/D25; snf1621; snRNP B''; snRNP-U1-A; U1-A; U1A; U2 snRNP; U2 snRNP B'' protein; U2B
Summary
Enables RNA binding activity and identical protein binding activity. Involved in oogenesis and regulation of alternative mRNA splicing, via spliceosome. Located in nucleus. Part of small nuclear ribonucleoprotein complex. Is expressed in adult head; embryonic brain; larval ventral nerve cord; and organism. Human ortholog(s) of this gene implicated in connective tissue disease. Orthologous to several human genes including SNRPB2 (small nuclear ribonucleoprotein polypeptide B2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
4F4-4F4; 1-11 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (5309242..5310501)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (5203275..5204534)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Cyclin-dependent kinase 7 Neighboring gene Thioredoxin T Neighboring gene deadhead

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A compare-and-contrast NMR dynamics study of two related RRMs: U1A and SNF. DeKoster GT, et al. Biophys J, 2014 Jul 1. PMID 24988355, Free PMC Article
  2. Resurrection of an Urbilaterian U1A/U2B″/SNF protein. Williams SG, et al. J Mol Biol, 2013 Oct 23. PMID 23796518, Free PMC Article
  3. RNA binding specificity of a Drosophila snRNP protein that shares sequence homology with mammalian U1-A and U2-B" proteins. Harper DS, et al. Nucleic Acids Res, 1992 Jul 25. PMID 1386424, Free PMC Article
  4. SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahma. Jordán-Pla A, et al. BMC Genomics, 2018 May 18. PMID 29776334, Free PMC Article
  5. A lesson from flex: consider the Y chromosome when assessing Drosophila sex-specific lethals. Cline TW. Development, 2001 Mar. PMID 11222155

See all (176) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin.
    Title: In vivo analysis reveals that ATP-hydrolysis couples remodeling to SWI/SNF release from chromatin.
  2. Data show that SWI/SNF complexes play a role in the cleavage of specific pre-mRNAs in animal cells.
    Title: SWI/SNF interacts with cleavage and polyadenylation factors and facilitates pre-mRNA 3' end processing.
  3. U2A' immobilizes SNF and RNA residues to restore U2 stem-loop IV binding affinity, while U1 stem-loop II binding does not require such adjustments. Study findings show how U2A' can modulate RNA specificity of SNF without changing SNF conformation or relying on direct RNA contacts.
    Title: Molecular principles underlying dual RNA specificity in the Drosophila SNF protein.
  4. SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahma
    Title: SWI/SNF regulates half of its targets without the need of ATP-driven nucleosome remodeling by Brahma.
  5. SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs.
    Title: SWI/SNF regulates the alternative processing of a specific subset of pre-mRNAs in Drosophila melanogaster.
  6. SNR1 functions as a regulatory subunit to modulate chromatin remodeling activities of the Brahma complex on target genes, including both activation and repression
    Title: Histone lysine demethylases function as co-repressors of SWI/SNF remodeling activities during Drosophila wing development.
  7. The binding mechanism of SNF changes depending on its RNA target; SNF's ability to bind Drosophila stem-loop (SL)IV along with its inability to bind human SLIV indicates that evolutionary adaptation has occurred in both the protein and the RNA.
    Title: Coevolution of Drosophila snf protein and its snRNA targets.
  8. SEX-LETHAL interacts with SANS-FILLE in the context of the U1 snRNP, through the characterization of a point mutation that interferes with both assembly into the U1 snRNP and complex formation with SEX-LETHAL.
    Title: Sex-lethal splicing autoregulation in vivo: interactions between SEX-LETHAL, the U1 snRNP and U2AF underlie male exon skipping.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U1 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U1 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables U2 snRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables poly(U) RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables pre-mRNA intronic pyrimidine-rich binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables snRNA stem-loop binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in RNA splicing TAS
Traceable Author Statement
more info
 PubMed 
involved_in female germ-line sex determination NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
 PubMed 
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in primary sex determination, soma NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome HMP PubMed 
involved_in regulation of alternative mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of U1 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U1 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of U2 snRNP ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of catalytic step 2 spliceosome HDA PubMed 
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 
part_of precatalytic spliceosome HDA PubMed 
part_of protein-containing complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small nuclear ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of small nuclear ribonucleoprotein complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of spliceosomal complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
sans fille
Names
CG4528-PA
Sans-fille
simply not fertile
snf-PA
splicing necessary factor

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    5309242..5310501
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_078490.4 → NP_511045.1  sans fille [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_511045.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P43332, Q9W4D7
    Related
    FBpp0070716
    Conserved Domains (3) summary
    COG0724
    Location:5 → 177
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12479
    Location:137 → 216
    RRM2_SNF; RNA recognition motif 2 found in Drosophila melanogaster sex determination protein SNF and similar proteins
    cl17169
    Location:6 → 96
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P43332.1 P43332

Gene LinkOut

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