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Gpr68 G protein-coupled receptor 68 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314386, updated on 5-Mar-2024

Summary

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Official Symbol
Gpr68provided by RGD
Official Full Name
G protein-coupled receptor 68provided by RGD
Primary source
RGD:1309559
See related
Ensembl:ENSRNOG00000046309 AllianceGenome:RGD:1309559
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in cellular response to pH. Predicted to act upstream of or within negative regulation of monocyte differentiation; positive regulation of insulin secretion involved in cellular response to glucose stimulus; and positive regulation of osteoclast development. Predicted to be integral component of membrane. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 2A6. Orthologous to human GPR68 (G protein-coupled receptor 68). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 47.3), Spleen (RPKM 36.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Gpr68 in Genome Data Viewer
Location:
6q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125865205..125895674, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (120135620..120166089, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124874151..124903949, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479467 Neighboring gene D-glutamate cyclase Neighboring gene uncharacterized LOC120103602 Neighboring gene coiled-coil domain containing 88C Neighboring gene protein phosphatase 4, regulatory subunit 3A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF. Zhao D, et al. ACS Chem Neurosci, 2022 Feb 2. PMID 35025202
  2. Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis. Yang M, et al. J Biol Chem, 2006 Aug 18. PMID 16787916
  3. Abnormalities in osteoclastogenesis and decreased tumorigenesis in mice deficient for ovarian cancer G protein-coupled receptor 1. Li H, et al. PLoS One, 2009 May 28. PMID 19479052, Free PMC Article
  4. Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification. Horiguchi K, et al. Cell Tissue Res, 2014 Nov. PMID 25129106
  5. Deficiency of proton-sensing ovarian cancer G protein-coupled receptor 1 attenuates glucose-stimulated insulin secretion. Nakakura T, et al. Endocrinology, 2012 Sep. PMID 22733973

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.
    Title: GPR68 Improves Nerve Damage and Myelination in an Immature Rat Model Induced by Sevoflurane Anesthesia by Activating cAMP/CREB to Mediate BDNF.
  2. S100beta-positive dendritic-like cells can sense an increase in extracellular protons via GPR68 and respond by the production of IL-6 in order to suppress the up-regulation of Pomc expression.
    Title: Proton receptor GPR68 expression in dendritic-cell-like S100β-positive cells of rat anterior pituitary gland: GPR68 induces interleukin-6 gene expression in extracellular acidification.
  3. OGR1 is expressed early during osteoclastogenesis both in vivo and in vitro and plays a role in osteoclast differentiation.
    Title: Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to pH IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to pH ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of monocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of osteoclast development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of insulin secretion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of osteoclast development ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ovarian cancer G-protein coupled receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001108049.1 → NP_001101519.1  ovarian cancer G-protein coupled receptor 1

    See identical proteins and their annotated locations for NP_001101519.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473982
    UniProtKB/TrEMBL
    A6JEH9, D3ZSW1
    Related
    ENSRNOP00000091078.1, ENSRNOT00000113620.1
    Conserved Domains (1) summary
    cd15367
    Location:32 → 307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    125865205..125895674 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112353.2 → XP_038968281.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    UniProtKB/TrEMBL
    A6JEH9, D3ZSW1
    Related
    ENSRNOP00000064586.1
    Conserved Domains (1) summary
    cd15367
    Location:32 → 307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. XM_039112352.2 → XP_038968280.1  ovarian cancer G-protein coupled receptor 1 isoform X1

    UniProtKB/TrEMBL
    A6JEH9, D3ZSW1
    Related
    ENSRNOP00000080372.1
    Conserved Domains (1) summary
    cd15367
    Location:32 → 307
    7tmA_GPR68_OGR1; G protein-coupled receptor 68, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version

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