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Rps6ka5 ribosomal protein S6 kinase A5 [ Rattus norvegicus (Norway rat) ]

Gene ID: 314384, updated on 13-Apr-2024

Summary

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Official Symbol
Rps6ka5provided by RGD
Official Full Name
ribosomal protein S6 kinase A5provided by RGD
Primary source
RGD:1308336
See related
Ensembl:ENSRNOG00000004362 AllianceGenome:RGD:1308336
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Msk1
Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including histone-serine phosphorylation; positive regulation of histone modification; and regulation of transcription, DNA-templated. Predicted to be located in nucleus. Predicted to be active in cytoplasm and nucleoplasm. Orthologous to human RPS6KA5 (ribosomal protein S6 kinase A5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 111.2), Brain (RPKM 106.2) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
6q32
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (125558434..125736576, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (119828823..120006190, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (124557892..124735787, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479248 Neighboring gene tetratricopeptide repeat domain 7B Neighboring gene U6 spliceosomal RNA Neighboring gene polycomb group ring finger 5 like 1 Neighboring gene uncharacterized LOC134479467 Neighboring gene uncharacterized LOC120103602 Neighboring gene D-glutamate cyclase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury. Zhong ZX, et al. J Mol Neurosci, 2019 Jun. PMID 30919247, Free PMC Article
  2. Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis. Gong P, et al. Cell Transplant, 2019 Jun. PMID 30744416, Free PMC Article
  3. Phosphorylation of mitogen- and stress-activated protein kinase-1 in astrocytic inflammation: a possible role in inhibiting production of inflammatory cytokines. Gong P, et al. PLoS One, 2013. PMID 24349124, Free PMC Article
  4. Spatiotemporal patterns and essential role of MSK1 expression after rat spinal cord injury. Li Z, et al. Neurochem Res, 2013 Dec. PMID 24142296
  5. Traumatic brain injury induces a downregulation of MSK1 in rat brain cortex. Ning B, et al. J Mol Neurosci, 2013 Feb. PMID 23065332

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Novel Insights into MSK1 Phosphorylation by MRKbeta in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.
    Title: Novel Insights into MSK1 Phosphorylation by MRKβ in Intracerebral Hemorrhage-Induced Neuronal Apoptosis.
  2. MSK1 knockdown promotes inflammation and apoptosis and inhibits functional recovery after spinal cord injury.
    Title: Inhibition of MSK1 Promotes Inflammation and Apoptosis and Inhibits Functional Recovery After Spinal Cord Injury.
  3. Hypoxic postconditioning induced a significant increase of phosphorylated MSK1 in neurons of hippocampus after transient global cerebral ischemia.
    Title: The roles of p38 MAPK/MSK1 signaling pathway in the neuroprotection of hypoxic postconditioning against transient global cerebral ischemia in adult rats.
  4. MSK1 phosphorylation is associated with the mitigation of brain injury and possibly acts as a negative regulator of inflammation.
    Title: Phosphorylation of mitogen- and stress-activated protein kinase-1 in astrocytic inflammation: a possible role in inhibiting production of inflammatory cytokines.
  5. data suggested that MSK1 might play important roles in CNS pathophysiology after spinal cord injury
    Title: Spatiotemporal patterns and essential role of MSK1 expression after rat spinal cord injury.
  6. MSK1 gene expression in rat brain cortex decreases following traumatic brain injury.
    Title: Traumatic brain injury induces a downregulation of MSK1 in rat brain cortex.
  7. the signaling pathways of MAPK, MSK1, and NF-kappaB play important roles in thrombin-induced iNOS expression in alveolar macrophages
    Title: Thrombin induces inducible nitric oxide synthase expression via the MAPK, MSK1, and NF-κB signaling pathways in alveolar macrophages.
  8. Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease through its role on chromatin remodeling at the PGC-1-alpha promoter.
    Title: Mitogen- and stress-activated protein kinase 1-induced neuroprotection in Huntington's disease: role on chromatin remodeling at the PGC-1-alpha promoter.
  9. MSK1 is expressed at highest levels in striatal and olfactory tubercle neurons and to a lesser degree in cerebellar Purkinje cells. MSK1 is also expressed in a subset of astroglia.
    Title: Differential localization of MAPK-activated protein kinases RSK1 and MSK1 in mouse brain.
  10. results show for the first time the potential role of JNKs, p38-MAPK and MSK1 in the mechanism of transducing the oxidative stress-signal to HOX-1, possibly promoting cell survival and preserving homeostasis
    Title: Involvement of JNKs and p38-MAPK/MSK1 pathways in H2O2-induced upregulation of heme oxygenase-1 mRNA in H9c2 cells.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables histone H2AS1 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S10 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables histone H3S28 kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables magnesium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in interleukin-1-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in post-translational protein modification ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ribosomal protein S6 kinase alpha-5
Names
mitogen and stress-activated protein kinase 1
ribosomal protein S6 kinase, 90kDa, polypeptide 5
ribosomal protein S6 kinase, polypeptide 5
NP_001382521.1
XP_006240500.1
XP_017449658.1
XP_017449660.1
XP_038968278.1
XP_038968279.1
XP_063118042.1
XP_063118043.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001395592.1 → NP_001382521.1  ribosomal protein S6 kinase alpha-5

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6A7D1
    Related
    ENSRNOP00000089479.1, ENSRNOT00000107141.1
    Conserved Domains (2) summary
    cd14179
    Location:417 → 726
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:47 → 379
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    125558434..125736576 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006240438.5 → XP_006240500.1  ribosomal protein S6 kinase alpha-5 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A7D1, A0A8I6ABQ6
    Related
    ENSRNOP00000091483.1
    Conserved Domains (3) summary
    smart00220
    Location:405 → 662
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14179
    Location:393 → 702
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:34 → 355
    PKc_like; Protein Kinases, catalytic domain

  2. XM_017594169.3 → XP_017449658.1  ribosomal protein S6 kinase alpha-5 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A7D1

  3. XM_063261972.1 → XP_063118042.1  ribosomal protein S6 kinase alpha-5 isoform X2

  4. XM_039112350.2 → XP_038968278.1  ribosomal protein S6 kinase alpha-5 isoform X3

    Conserved Domains (2) summary
    cd14179
    Location:199 → 508
    STKc_MSK1_C; C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1
    cl21453
    Location:1 → 161
    PKc_like; Protein Kinases, catalytic domain

  5. XM_063261973.1 → XP_063118043.1  ribosomal protein S6 kinase alpha-5 isoform X3

  6. XM_017594171.3 → XP_017449660.1  ribosomal protein S6 kinase alpha-5 isoform X4

  7. XM_039112351.2 → XP_038968279.1  ribosomal protein S6 kinase alpha-5 isoform X5

    UniProtKB/TrEMBL
    A6JEH6, D3ZY17
    Conserved Domains (1) summary
    cl21453
    Location:47 → 379
    PKc_like; Protein Kinases, catalytic domain

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001108048.1: Suppressed sequence

    Description
    NM_001108048.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

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