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Prkd3 protein kinase D3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 313834, updated on 13-Apr-2024

Summary

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Official Symbol
Prkd3provided by RGD
Official Full Name
protein kinase D3provided by RGD
Primary source
RGD:1310236
See related
Ensembl:ENSRNOG00000005289 AllianceGenome:RGD:1310236
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Prkcn
Summary
Predicted to enable kinase activity. Predicted to be involved in protein kinase D signaling. Predicted to be located in cytosol and nucleoplasm. Orthologous to human PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 318.5), Lung (RPKM 232.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Prkd3 in Genome Data Viewer
Location:
6q12
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (21784665..21860600)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (16032507..16108444)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (1546018..1622232, complement)

Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene glutaminyl-peptide cyclotransferase Neighboring gene ribosomal protein S17, pseudogene 9 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 7 Neighboring gene CCAAT/enhancer binding protein zeta Neighboring gene CEBPZ opposite strand

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors. Li C, et al. J Biol Chem, 2011 Nov 25. PMID 21971046, Free PMC Article
  2. Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD). Wang J, et al. J Biol Chem, 2016 Aug 19. PMID 27369082, Free PMC Article
  3. Protein kinase D 3 is localized in vesicular structures and interacts with vesicle-associated membrane protein 2. Lu G, et al. Cell Signal, 2007 Apr. PMID 17196367
  4. Protein kinase D regulates RhoA activity via rhotekin phosphorylation. Pusapati GV, et al. J Biol Chem, 2012 Mar 16. PMID 22228765, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. siRNA-mediated knockdown of PKD1, PKD2, and PKD3 markedly attenuated YAP nuclear-cytoplasmic shuttling, phosphorylation at Ser(127), and induction of Ctgf and Areg expression in response to GPCR activation.
    Title: Biphasic Regulation of Yes-associated Protein (YAP) Cellular Localization, Phosphorylation, and Activity by G Protein-coupled Receptor Agonists in Intestinal Epithelial Cells: A NOVEL ROLE FOR PROTEIN KINASE D (PKD).
  2. PKD3 is a pivotal mediator of the CaN-NFATc1/c3-PKD3-NFATc4 hypertrophic signaling cascade and a potential new drug target for the pathological cardiac hypertrophy
    Title: Protein kinase D3 is a pivotal activator of pathological cardiac hypertrophy by selectively increasing the expression of hypertrophic transcription factors.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase D3
Names
protein kinase C, nu
NP_001019434.2
XP_006239691.1
XP_006239693.1
XP_038968056.1
XP_038968057.1
XP_063117874.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001024263.2 → NP_001019434.2  serine/threonine-protein kinase D3

    See identical proteins and their annotated locations for NP_001019434.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000006
    UniProtKB/TrEMBL
    A0A8I6G5U2, D4A229
    Related
    ENSRNOP00000007491.4, ENSRNOT00000007492.8
    Conserved Domains (4) summary
    cd01239
    Location:410 → 534
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572 → 831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20841
    Location:145 → 219
    C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
    cl00040
    Location:267 → 335
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086024.1 Reference GRCr8

    Range
    21784665..21860600
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039112129.2 → XP_038968057.1  serine/threonine-protein kinase D3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G5U2
    Related
    ENSRNOP00000079860.1
    Conserved Domains (4) summary
    cd01239
    Location:306 → 430
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:468 → 727
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20841
    Location:41 → 115
    C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
    cl00040
    Location:163 → 231
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  2. XM_039112128.2 → XP_038968056.1  serine/threonine-protein kinase D3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6G5U2, D4A229
    Conserved Domains (4) summary
    cd01239
    Location:410 → 534
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572 → 831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20841
    Location:145 → 219
    C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
    cl00040
    Location:267 → 335
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  3. XM_006239629.5 → XP_006239691.1  serine/threonine-protein kinase D3 isoform X1

    See identical proteins and their annotated locations for XP_006239691.1

    UniProtKB/TrEMBL
    A0A8I6G5U2, D4A229
    Conserved Domains (4) summary
    cd01239
    Location:410 → 534
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:572 → 831
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20841
    Location:145 → 219
    C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
    cl00040
    Location:267 → 335
    C1; protein kinase C conserved region 1 (C1 domain) superfamily

  4. XM_063261804.1 → XP_063117874.1  serine/threonine-protein kinase D3 isoform X1

    UniProtKB/TrEMBL
    D4A229

  5. XM_006239631.5 → XP_006239693.1  serine/threonine-protein kinase D3 isoform X2

    UniProtKB/TrEMBL
    A0A8I6G5U2
    Conserved Domains (4) summary
    cd01239
    Location:306 → 430
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:468 → 727
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20841
    Location:41 → 115
    C1_PKD3_rpt1; first protein kinase C conserved region 1 (C1 domain) found in protein kinase D3 (PKD3) and similar proteins
    cl00040
    Location:163 → 231
    C1; protein kinase C conserved region 1 (C1 domain) superfamily
Nucleotide Protein Strain
Heading Accession and Version

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