Dhrs3 dehydrogenase/reductase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dhrs3provided by RGD
Official Full Name: dehydrogenase/reductase 3provided by RGD
Primary source: RGD:1305584
See related: Ensembl:ENSRNOG00000015736 AllianceGenome:RGD:1305584
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable NAD-retinol dehydrogenase activity. Predicted to be involved in regulation of retinoic acid receptor signaling pathway and retinoid metabolic process. Predicted to act upstream of or within several processes, including animal organ morphogenesis; negative regulation of retinoic acid receptor signaling pathway; and regulation of ossification. Predicted to be integral component of membrane. Predicted to be active in lipid droplet. Orthologous to human DHRS3 (dehydrogenase/reductase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Liver (RPKM 586.1), Adrenal (RPKM 434.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (162031853..162065655)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (156747939..156782420)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (162809090..162843385)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

D5Rat47 (e-PCR)
- UniSTS:118916

AU049431 (e-PCR)
- UniSTS:145878

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans-retinol dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables all-trans-retinol dehydrogenase (NAD+) activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac septum morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of ossification	ISO Inferred from Sequence Orthology more info
involved_in regulation of retinoic acid receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in retinoid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within retinoid metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in lipid droplet	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: short-chain dehydrogenase/reductase 3

Names: dehydrogenase/reductase (SDR family) member 3; dehydrogenase/reductase member 2; retinal dehydrogenase/reductase family member 3

NP_001032276.3

EC 1.1.1.300

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001037199.3 → NP_001032276.3 short-chain dehydrogenase/reductase 3

See identical proteins and their annotated locations for NP_001032276.3

Status: PROVISIONAL

Source sequence(s)

BC107450

UniProtKB/TrEMBL

A1YR15, A6IU09, F7FCZ4, Q3B7V0

Related

ENSRNOP00000021155.5, ENSRNOT00000021155.6

Conserved Domains (2) summary

cd05339
Location:53 → 281

17beta-HSDXI-like_SDR_c; human 17-beta-hydroxysteroid dehydrogenase XI-like, classical (c) SDRs

PRK09072
Location:35 → 288

PRK09072; short chain dehydrogenase; Provisional