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Rap1gap Rap1 GTPase-activating protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 313644, updated on 13-Apr-2024

Summary

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Official Symbol
Rap1gapprovided by RGD
Official Full Name
Rap1 GTPase-activating proteinprovided by RGD
Primary source
RGD:1309908
See related
Ensembl:ENSRNOG00000013825 AllianceGenome:RGD:1309908
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Rap1ga1
Summary
Predicted to enable GTPase activator activity; protein homodimerization activity; and small GTPase binding activity. Involved in several processes, including cellular response to glial cell derived neurotrophic factor; negative regulation of GTP binding activity; and negative regulation of thyroid gland epithelial cell proliferation. Located in several cellular components, including dendrite; early endosome; and neuronal cell body. Orthologous to human RAP1GAP (RAP1 GTPase activating protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 252.8), Kidney (RPKM 125.7) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q36
Exon count:
31
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (155157511..155222622)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (149873987..149939254)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (156008868..156074350)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene interferon induced transmembrane protein 2, pseudogene 3 Neighboring gene ubiquitin specific peptidase 48 Neighboring gene alkaline phosphatase, biomineralization associated Neighboring gene uncharacterized LOC134487019 Neighboring gene U4 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms. Korayem AH, et al. Am J Physiol Heart Circ Physiol, 2017 Jul 1. PMID 28476918, Free PMC Article
  2. Regulation of cortical dendrite development by Rap1 signaling. Chen Y, et al. Mol Cell Neurosci, 2005 Feb. PMID 15691704
  3. Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway. Qin M, et al. J Biochem Mol Toxicol, 2021 Jan. PMID 32864822
  4. Enhanced Rap1 activation and insulin secretagogue properties of an acetoxymethyl ester of an Epac-selective cyclic AMP analog in rat INS-1 cells: studies with 8-pCPT-2'-O-Me-cAMP-AM. Chepurny OG, et al. J Biol Chem, 2009 Apr 17. PMID 19244230, Free PMC Article
  5. Down-regulation of Rap1GAP via promoter hypermethylation promotes melanoma cell proliferation, survival, and migration. Zheng H, et al. Cancer Res, 2009 Jan 15. PMID 19147557

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
    Title: Downregulating miR-184 relieves calcium oxalate crystal-mediated renal cell damage via activating the Rap1 signaling pathway.
  2. Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway.
    Title: Rutin treats myocardial damage caused by pirarubicin via regulating miR-22-5p-regulated RAP1/ERK signaling pathway.
  3. the present study shows that down-regulated miR-182-5p promotes the proliferation and differentiation of osteoblasts in Osteoporosis (OP) rats through Rap1/MAPK signaling pathway activation by up-regulating ADCY6, which may represent a novel target for OP treatment
    Title: Decreased microRNA-182-5p helps alendronate promote osteoblast proliferation and differentiation in osteoporosis via the Rap1/MAPK pathway.
  4. Here, we demonstrate that 1) stimulation of cAMP production deactivates ischemia-reperfusion-induced hyperpermeability in muscle and endothelial cells; 2) VEGF mRNA expression is not enhanced by brief ischemia, suggesting that VEGF mechanisms do not activate immediate postischemic hyperpermeability; and 3) deactivation mechanisms operate via cAMP-exchange protein activated by cAMP 1-Rap1 to restore integrity of the endot
    Title: Endothelial cAMP deactivates ischemia-reperfusion-induced microvascular hyperpermeability via Rap1-mediated mechanisms.
  5. results have shown a novel role of PLCepsilon in the maintenance of endothelial barrier function, via its CDC25 GEF domain and lipase activity, and subsequent up-regulation of Rap1 activity
    Title: Phospholipase Cε Modulates Rap1 Activity and the Endothelial Barrier.
  6. Rap1GAP negatively regulated GNDF-induced ERK activation and neurite outgrowth.
    Title: Rap1GAP interacts with RET and suppresses GDNF-induced neurite outgrowth.
  7. Data suggest that cAMP-dependent PACAP-induced GFAP expression during astrocytogenesis involves the coordinated activation of both Ras and Rap1, but activation of either one of them in isolation is not sufficient to trigger this response.
    Title: Pituitary adenylate cyclase-activating polypeptide stimulates glial fibrillary acidic protein gene expression in cortical precursor cells by activating Ras and Rap1.
  8. Disruption of the DEP-dependent subcellular targeting of Epac abolished cAMP-Epac-mediated Rap1 activation and thyroid-stimulating hormone-mediated cell proliferation
    Title: Epac, in synergy with cAMP-dependent protein kinase (PKA), is required for cAMP-mediated mitogenesis.
  9. a model in which activation of G(z) results in recruitment of Rap1GAP to the membrane where it can effectively down-regulate Rap1 signaling (Rap1)(Rap1GAP)
    Title: Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells.
  10. Rap1 and MEKK2 are critical upstream signaling molecules mediating BDNF stimulation of ERK5 in central nervous system neurons
    Title: Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
enables small GTPase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to glial cell derived neurotrophic factor IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of establishment of localization in cell ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of microvillus assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of thyroid gland epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of phagocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of small GTPase mediated signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
rap1 GTPase-activating protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001100713.2 → NP_001094183.1  rap1 GTPase-activating protein 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6ITE6, F1LV89
    Related
    ENSRNOP00000048749.5, ENSRNOT00000046802.6
    Conserved Domains (2) summary
    smart00390
    Location:61 → 81
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:275 → 454
    Rap_GAP; Rap/ran-GAP

  2. NM_001415932.1 → NP_001402861.1  rap1 GTPase-activating protein 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A6ITE4

  3. NM_001415933.1 → NP_001402862.1  rap1 GTPase-activating protein 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    155157511..155222622
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287788.1 → XP_063143858.1  rap1 GTPase-activating protein 1 isoform X16

  2. XM_017593413.2 → XP_017448902.1  rap1 GTPase-activating protein 1 isoform X14

    UniProtKB/TrEMBL
    A6ITE6

  3. XM_063287787.1 → XP_063143857.1  rap1 GTPase-activating protein 1 isoform X15

  4. XM_063287779.1 → XP_063143849.1  rap1 GTPase-activating protein 1 isoform X3

  5. XM_017593409.3 → XP_017448898.1  rap1 GTPase-activating protein 1 isoform X5

    UniProtKB/TrEMBL
    A6ITE6
    Related
    ENSRNOP00000079431.1

  6. XM_063287784.1 → XP_063143854.1  rap1 GTPase-activating protein 1 isoform X11

  7. XM_063287778.1 → XP_063143848.1  rap1 GTPase-activating protein 1 isoform X2

  8. XM_063287780.1 → XP_063143850.1  rap1 GTPase-activating protein 1 isoform X4

  9. XM_063287782.1 → XP_063143852.1  rap1 GTPase-activating protein 1 isoform X8

  10. XM_063287783.1 → XP_063143853.1  rap1 GTPase-activating protein 1 isoform X10

  11. XM_063287785.1 → XP_063143855.1  rap1 GTPase-activating protein 1 isoform X12

  12. XM_063287786.1 → XP_063143856.1  rap1 GTPase-activating protein 1 isoform X14

  13. XM_063287777.1 → XP_063143847.1  rap1 GTPase-activating protein 1 isoform X1

  14. XM_017593410.3 → XP_017448899.1  rap1 GTPase-activating protein 1 isoform X7

    UniProtKB/TrEMBL
    A6ITE6

  15. XM_063287781.1 → XP_063143851.1  rap1 GTPase-activating protein 1 isoform X6

  16. XM_017593412.3 → XP_017448901.1  rap1 GTPase-activating protein 1 isoform X9

    UniProtKB/TrEMBL
    A6ITE6

  17. XM_039110059.2 → XP_038965987.1  rap1 GTPase-activating protein 1 isoform X13

    UniProtKB/TrEMBL
    A0A8I6AU92, A6ITE6
    Related
    ENSRNOP00000097348.1
    Conserved Domains (2) summary
    smart00390
    Location:28 → 48
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    pfam02145
    Location:242 → 421
    Rap_GAP; Rap/ran-GAP

RNA

  1. XR_354337.3 RNA Sequence

  2. XR_354338.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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