C8b complement C8 beta chain [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: C8bprovided by RGD
Official Full Name: complement C8 beta chainprovided by RGD
Primary source: RGD:2239
See related: Ensembl:ENSRNOG00000007639 AllianceGenome:RGD:2239
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in complement activation, alternative pathway; complement activation, classical pathway; and cytolysis. Located in extracellular space. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in type II complement component 8 deficiency. Orthologous to human C8B (complement C8 beta chain). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Restricted expression toward (RPKM 1517.6) See more
Orthologs: human mouse all
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Genomic context

Location:: 5q34

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (124763974..124801522)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (119535009..119572565)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (124298269..124338055)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

d5rat198 (e-PCR)
- UniSTS:122121

GDB:352688 (e-PCR)
- UniSTS:156701

D5Rhm3 (e-PCR)
- UniSTS:517806

D5Rhm4 (e-PCR)
- UniSTS:517849

RH133281 (e-PCR)
- UniSTS:216564

RH142430 (e-PCR)
- UniSTS:231677

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables protein-containing complex binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in complement activation	IBA Inferred from Biological aspect of Ancestor more info
involved_in complement activation, alternative pathway	IEA Inferred from Electronic Annotation more info
involved_in complement activation, classical pathway	IEA Inferred from Electronic Annotation more info
involved_in killing of cells of another organism	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of membrane attack complex	IBA Inferred from Biological aspect of Ancestor more info
part_of membrane attack complex	IEA Inferred from Electronic Annotation more info
part_of membrane attack complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: complement component C8 beta chain

Names: complement component 8 subunit beta; complement component 8, beta polypeptide; complement component 8, beta subunit

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191759.1 → NP_001178688.1 complement component C8 beta chain precursor

See identical proteins and their annotated locations for NP_001178688.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000005

UniProtKB/Swiss-Prot

P55314, Q5EB58

UniProtKB/TrEMBL

A0A8I5ZWX9, A6JRT7

Related

ENSRNOP00000010100.5, ENSRNOT00000010100.8

Conserved Domains (3) summary

smart00209
Location:547 → 589

TSP1; Thrombospondin type 1 repeats

smart00457
Location:291 → 497

MACPF; membrane-attack complex / perforin

pfam00057
Location:119 → 154

Ldl_recept_a; Low-density lipoprotein receptor domain class A

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

124763974..124801522

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109958.2 → XP_038965886.1 complement component C8 beta chain isoform X1

Conserved Domains (2) summary

smart00209
Location:67 → 112

TSP1; Thrombospondin type 1 repeats

pfam00057
Location:119 → 154

Ldl_recept_a; Low-density lipoprotein receptor domain class A