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Msc musculin [ Rattus norvegicus (Norway rat) ]

Gene ID: 312897, updated on 13-Apr-2024

Summary

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Official Symbol
Mscprovided by RGD
Official Full Name
musculinprovided by RGD
Primary source
RGD:1305496
See related
Ensembl:ENSRNOG00000007540 AllianceGenome:RGD:1305496
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II; roof of mouth development; and skeletal muscle organ development. Predicted to act upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleoplasm. Orthologous to human MSC (musculin). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 29.6), Heart (RPKM 15.3) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
5q11
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (9330522..9336391)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (4547335..4553206)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (3954902..3956974)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134487053 Neighboring gene uncharacterized LOC102555885 Neighboring gene uncharacterized LOC134487106 Neighboring gene NADH:ubiquinone oxidoreductase subunit B4, pseudogene 8 Neighboring gene EYA transcriptional coactivator and phosphatase 1 Neighboring gene uncharacterized LOC120102805

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. MyoR: a muscle-restricted basic helix-loop-helix transcription factor that antagonizes the actions of MyoD. Lu J, et al. Proc Natl Acad Sci U S A, 1999 Jan 19. PMID 9892671, Free PMC Article
  2. Control of facial muscle development by MyoR and capsulin. Lu JR, et al. Science, 2002 Dec 20. PMID 12493912
  3. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Nishiyama A, et al. Cell Stem Cell, 2009 Oct 2. PMID 19796622, Free PMC Article
  4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in branchiomeric skeletal muscle development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cellular response to leukemia inhibitory factor ISO
Inferred from Sequence Orthology
more info
  
involved_in diaphragm development ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in roof of mouth development ISO
Inferred from Sequence Orthology
more info
  
involved_in skeletal muscle tissue development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
musculin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001191754.2 → NP_001178683.1  musculin

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000005
    UniProtKB/TrEMBL
    A0A8I5ZNI8, A6JFC6
    Conserved Domains (1) summary
    cd19703
    Location:102 → 167
    bHLH_TS_musculin; basic helix-loop-helix (bHLH) domain found in musculin and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    9330522..9336391
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109741.2 → XP_038965669.1  musculin isoform X1

    UniProtKB/TrEMBL
    D3ZWP1
    Conserved Domains (1) summary
    cd19703
    Location:102 → 167
    bHLH_TS_musculin; basic helix-loop-helix (bHLH) domain found in musculin and similar proteins

  2. XM_039109742.2 → XP_038965670.1  musculin isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZNI8, A6JFC6
    Related
    ENSRNOP00000079652.1
    Conserved Domains (1) summary
    cd19703
    Location:102 → 167
    bHLH_TS_musculin; basic helix-loop-helix (bHLH) domain found in musculin and similar proteins
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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