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Akap3 A-kinase anchoring protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 312720, updated on 11-Apr-2024

Summary

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Official Symbol
Akap3provided by RGD
Official Full Name
A-kinase anchoring protein 3provided by RGD
Primary source
RGD:1359735
See related
Ensembl:ENSRNOG00000059227 AllianceGenome:RGD:1359735
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein kinase A binding activity. Predicted to be involved in protein localization. Predicted to act upstream of or within blastocyst hatching and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to be located in acrosomal vesicle; sperm fibrous sheath; and sperm midpiece. Predicted to be active in cytoplasm and sperm principal piece. Orthologous to human AKAP3 (A-kinase anchoring protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 673.6) See more
Orthologs
human mouse all
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Genomic context

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Location:
4q42
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (161374198..161400062)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (159688049..159714067)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (159399686..159425512)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene polypeptide N-acetylgalactosaminyltransferase 8 Neighboring gene NADH:ubiquinone oxidoreductase subunit A9 Neighboring gene uncharacterized LOC134486843 Neighboring gene dual specificity tyrosine phosphorylation regulated kinase 4 Neighboring gene RAD51 associated protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Homozygous loss-of-function mutations in FSIP2 cause male infertility with asthenoteratospermia. Liu W, et al. J Genet Genomics, 2019 Jan 20. PMID 30745215
  2. Isolation and molecular characterization of AKAP110, a novel, sperm-specific protein kinase A-anchoring protein. Vijayaraghavan S, et al. Mol Endocrinol, 1999 May. PMID 10319321
  3. Association of sperm protein 17 with A-kinase anchoring protein 3 in flagella. Lea IA, et al. Reprod Biol Endocrinol, 2004 Jul 16. PMID 15257753, Free PMC Article
  4. A-kinase anchoring protein 4 binding proteins in the fibrous sheath of the sperm flagellum. Brown PR, et al. Biol Reprod, 2003 Jun. PMID 12606363
  5. Identification of sperm-specific proteins that interact with A-kinase anchoring proteins in a manner similar to the type II regulatory subunit of PKA. Carr DW, et al. J Biol Chem, 2001 May 18. PMID 11278869

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC93915

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein kinase A binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase A binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within blastocyst hatching ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within cell surface receptor protein serine/threonine kinase signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in motile cilium ISO
Inferred from Sequence Orthology
more info
  
located_in sperm fibrous sheath ISO
Inferred from Sequence Orthology
more info
  
located_in sperm midpiece ISO
Inferred from Sequence Orthology
more info
  
is_active_in sperm principal piece IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm principal piece ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
A-kinase anchor protein 3
Names
A kinase (PRKA) anchor protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005557.1 → NP_001005557.1  A-kinase anchor protein 3

    See identical proteins and their annotated locations for NP_001005557.1

    Status: PROVISIONAL

    Source sequence(s)
    BC081924
    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Related
    ENSRNOP00000072217.1, ENSRNOT00000086525.2
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    161374198..161400062
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039107684.2 → XP_038963612.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  2. XM_006237492.5 → XP_006237554.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006237554.1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  3. XM_008763290.3 → XP_008761512.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008761512.1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  4. XM_063286144.1 → XP_063142214.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  5. XM_063286147.1 → XP_063142217.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  6. XM_063286145.1 → XP_063142215.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  7. XM_063286143.1 → XP_063142213.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  8. XM_063286146.1 → XP_063142216.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  9. XM_063286142.1 → XP_063142212.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6

  10. XM_039107683.2 → XP_038963611.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  11. XM_017592653.3 → XP_017448142.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  12. XM_017592654.3 → XP_017448143.1  A-kinase anchor protein 3 isoform X1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  13. XM_006237489.4 → XP_006237551.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006237551.1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  14. XM_006237488.5 → XP_006237550.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006237550.1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa

  15. XM_008763289.4 → XP_008761511.1  A-kinase anchor protein 3 isoform X1

    See identical proteins and their annotated locations for XP_008761511.1

    UniProtKB/TrEMBL
    A0A0G2K2E9, Q66HC6
    Conserved Domains (1) summary
    smart00807
    Location:5 → 858
    AKAP_110; A-kinase anchor protein 110 kDa
Nucleotide Protein Strain
Heading Accession and Version

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