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C1r complement C1r [ Rattus norvegicus (Norway rat) ]

Gene ID: 312705, updated on 11-Apr-2024

Summary

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Official Symbol
C1rprovided by RGD
Official Full Name
complement C1rprovided by RGD
Primary source
RGD:1309091
See related
Ensembl:ENSRNOG00000011796 AllianceGenome:RGD:1309091
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable calcium ion binding activity; identical protein binding activity; and serine-type endopeptidase activity. Predicted to be involved in zymogen activation. Predicted to be active in blood microparticle. Human ortholog(s) of this gene implicated in Ehlers-Danlos syndrome periodontal type 1. Orthologous to human C1R (complement C1r). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1161.1), Adrenal (RPKM 767.6) and 8 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4q42
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (159099013..159109770)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (157412718..157423483)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (157126060..157136825)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102553636 Neighboring gene uncharacterized LOC120102383 Neighboring gene complement C1r subcomponent like Neighboring gene uncharacterized LOC102553847 Neighboring gene complement C1s Neighboring gene uncharacterized LOC134486639

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Interaction between separated consecutive complement control modules of human C1r: implications for dimerization of the full-length protease. Láng A, et al. FEBS Lett, 2010 Nov 19. PMID 20970424
  2. Calcium-dependent conformational flexibility of a CUB domain controls activation of the complement serine protease C1r. Major B, et al. J Biol Chem, 2010 Apr 16. PMID 20178990, Free PMC Article
  3. Alterations of the classic pathway of complement in adipose tissue of obesity and insulin resistance. Zhang J, et al. Am J Physiol Endocrinol Metab, 2007 May. PMID 17244723
  4. The crystal structure of the zymogen catalytic domain of complement protease C1r reveals that a disruptive mechanical stress is required to trigger activation of the C1 complex. Budayova-Spano M, et al. EMBO J, 2002 Feb 1. PMID 11823416, Free PMC Article
  5. C1R Mutations Trigger Constitutive Complement 1 Activation in Periodontal Ehlers-Danlos Syndrome. Gröbner R, et al. Front Immunol, 2019. PMID 31749804, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables calcium ion binding ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables molecular sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in complement activation, classical pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in zymogen activation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in zymogen activation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
complement C1r subcomponent
Names
complement component 1, r subcomponent
NP_001128027.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134555.3 → NP_001128027.1  complement C1r subcomponent precursor

    See identical proteins and their annotated locations for NP_001128027.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    B5DEH7, D4A1T6
    Related
    ENSRNOP00000069123.1, ENSRNOT00000078349.2
    Conserved Domains (6) summary
    smart00020
    Location:463 → 699
    Tryp_SPc; Trypsin-like serine protease
    smart00042
    Location:27 → 138
    CUB; Domain first found in C1r, C1s, uEGF, and bone morphogenetic protein
    cd00190
    Location:464 → 701
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
    pfam00084
    Location:309 → 371
    Sushi; Sushi repeat (SCR repeat)
    pfam00431
    Location:195 → 302
    CUB; CUB domain
    pfam14670
    Location:161 → 189
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    159099013..159109770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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