Cyp26b1 cytochrome P450, family 26, subfamily b, polypeptide 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cyp26b1provided by RGD
Official Full Name: cytochrome P450, family 26, subfamily b, polypeptide 1provided by RGD
Primary source: RGD:631379
See related: Ensembl:ENSRNOG00000015076 AllianceGenome:RGD:631379
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables retinoic acid 4-hydroxylase activity. Involved in several processes, including response to retinoic acid; response to vitamin A; and retinoic acid catabolic process. Predicted to be located in cytoplasm. Orthologous to human CYP26B1 (cytochrome P450 family 26 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 56.2), Lung (RPKM 54.1) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q34

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (118599356..118616176, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (117041808..117058628, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (116261796..116278615, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

5ML induces CYP26B1-dependent angiogenesis in vitro, and arteriogenesis in vivo.
Title: 5-Methoxyleoligin, a lignan from Edelweiss, stimulates CYP26B1-dependent angiogenesis in vitro and induces arteriogenesis in infarcted rat hearts in vivo.

Submit: New GeneRIF Correction

General gene information

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Markers

UniSTS:464663 (e-PCR)
- UniSTS:464663

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:464663

BF398420 (e-PCR)
- UniSTS:246808

Cyp26b1 (e-PCR), detects polymorphism
- UniSTS:525748

D4Got92 (e-PCR)
- UniSTS:115447

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables all-trans retinoic acid 18-hydroxylase activity	IEA Inferred from Electronic Annotation more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables monooxygenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	ISS Inferred from Sequence or Structural Similarity more info
enables retinoic acid 4-hydroxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables retinoic acid 4-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables retinoic acid binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate determination	ISO Inferred from Sequence Orthology more info
involved_in cellular response to retinoic acid	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cornification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic limb morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of T cell polarity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within establishment of skin barrier	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in kidney development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within male meiotic nuclear division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tongue muscle cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proximal/distal pattern formation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of T cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in response to retinoic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin A	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinoic acid catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retinoic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid metabolic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in retinoic acid receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within spermatogenesis	ISO Inferred from Sequence Orthology more info
involved_in sterol metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tongue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISO Inferred from Sequence Orthology more info
involved_in xenobiotic metabolic process	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 26B1

NP_851601.2

EC 1.14.13.-

XP_063142134.1

EC 1.14.13.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181087.3 → NP_851601.2 cytochrome P450 26B1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

G3V7X8, Q80YE5

UniProtKB/TrEMBL

A0A8I6AMJ8

Related

ENSRNOP00000020505.3, ENSRNOT00000020505.4

Conserved Domains (1) summary

cd20637
Location:60 → 490

CYP26B1; cytochrome P450 family 26, subfamily B, polypeptide 1