Abcg2 ATP binding cassette subfamily G member 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abcg2provided by RGD
Official Full Name: ATP binding cassette subfamily G member 2provided by RGD
Primary source: RGD:631345
See related: Ensembl:ENSRNOG00000007041 AllianceGenome:RGD:631345
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Bcrp; BCRP1
Summary: Enables several functions, including cytoskeletal protein binding activity; efflux transmembrane transporter activity; and xenobiotic transmembrane transporter activity. Involved in several processes, including cellular response to lipid; embryonic process involved in female pregnancy; and urate salt excretion. Located in external side of apical plasma membrane and nucleus. Biomarker of diabetes mellitus; secondary hyperparathyroidism; status epilepticus; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in gout; hematologic cancer (multiple); renal cell carcinoma; and toxic encephalopathy. Orthologous to human ABCG2 (ATP binding cassette subfamily G member 2 (Junior blood group)). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 256.7), Brain (RPKM 36.1) and 6 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q24

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (89006056..89132915)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (87676241..87802757)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (88765441..88890268)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.
Title: Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.
Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins.
Title: Bile duct ligation causes opposite impacts on the expression and function of BCRP and P-gp in rat brain partly via affecting membrane expression of ezrin/radixin/moesin proteins.
Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Title: Metabolomic and transcriptomic analysis reveals endogenous substrates and metabolic adaptation in rats lacking Abcg2 and Abcb1a transporters.
Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.
Title: Hypouricemic agents reduce indoxyl sulfate excretion by inhibiting the renal transporters OAT1/3 and ABCG2.
ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat.
Title: ABCG2 expression and uric acid metabolism of the intestine in hyperuricemia model rat.
The ROS-mediated increase in the synthesis of MRP-1 and BCRP can play an important role in hyperoxaluria-promoted calcium oxalate urolithiasis by facilitating phosphatidylserine redistribution in renal epithelial cells.
Title: MRP-1 and BCRP Promote the Externalization of Phosphatidylserine in Oxalate-treated Renal Epithelial Cells: Implications for Calcium Oxalate Urolithiasis.
conclusion, MDR1 and BCRP are expressed on apical membranes of the rodent placental SynT-II layer.
Title: Layer II of placental syncytiotrophoblasts expresses MDR1 and BCRP at the apical membrane in rodents.
Folate deficiency alters the expression of folate transporters RFC and folate exporter ABCG2 in the adult group differently than weanling group and young group both at the transcriptional and translational level, which in turn was found to be epigenetically regulated by promoter methylation of the RFC and ABCG2 genes.
Title: Gene specific epigenetic regulation of hepatic folate transport system is responsible for perturbed cellular folate status during aging and exogenous modulation.
Parathryoid hormone down-regulates ABCG2 expression on the plasma membrane to suppress intestinal and renal urate excretion in secondary hyperparathyroidism leading to hyperuricemia.
Title: Down-regulation of ABCG2, a urate exporter, by parathyroid hormone enhances urate accumulation in secondary hyperparathyroidism.
Insulin significantly increased URAT1 and decreased ABCG2 levels, resulting in increased kidney tubule uric acid reabsorption in streptozotocin-diabetic rats.
Title: Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2.

Submit: New GeneRIF Correction See all GeneRIFs (46)

General gene information

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Markers

RH130231 (e-PCR)
- UniSTS:213518

AI428558 (e-PCR)
- UniSTS:159513

RH143656 (e-PCR)
- UniSTS:232902

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ABC-type xenobiotic transporter activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables ATPase-coupled transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATPase-coupled transmembrane transporter activity	TAS Traceable Author Statement more info	PubMed
enables amide transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables biotin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables biotin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables cytoskeletal protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables efflux transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables efflux transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables riboflavin transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables riboflavin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables riboflavin transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables xenobiotic transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in biotin transport	ISO Inferred from Sequence Orthology more info
involved_in biotin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular detoxification	ISO Inferred from Sequence Orthology more info
involved_in cellular response to dexamethasone stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to estradiol stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryonic process involved in female pregnancy	IDA Inferred from Direct Assay more info	PubMed
involved_in export across plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in glucuronoside metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lipid transport	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intestinal absorption	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in organic anion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in renal urate salt excretion	IEP Inferred from Expression Pattern more info	PubMed
involved_in renal urate salt excretion	ISO Inferred from Sequence Orthology more info
involved_in response to 2,3,7,8-tetrachlorodibenzodioxine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to alcohol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to folic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to insulin	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to iron ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in riboflavin transport	ISO Inferred from Sequence Orthology more info
involved_in riboflavin transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in transepithelial transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	ISS Inferred from Sequence or Structural Similarity more info
involved_in urate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in urate transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in xenobiotic detoxification by transmembrane export across the plasma membrane	IDA Inferred from Direct Assay more info	PubMed
involved_in xenobiotic transport across blood-brain barrier	IC Inferred by Curator more info	PubMed
involved_in xenobiotic transport across blood-brain barrier	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISO Inferred from Sequence Orthology more info
located_in brush border membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in external side of apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane raft	ISO Inferred from Sequence Orthology more info
located_in membrane raft	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: broad substrate specificity ATP-binding cassette transporter ABCG2

Names: ATP binding cassette subfamily G member 2 (Junior blood group); ATP-binding cassette protein G2; ATP-binding cassette sub-family G member 2; ATP-binding cassette, sub-family G (WHITE), member 2; ATP-binding cassette, subfamily G (WHITE), member 2; breast cancer resistance protein 1 homolog; urate exporter

NP_852046.1

EC 7.6.2.2

XP_006236635.1

EC 7.6.2.2

XP_006236638.1

EC 7.6.2.2

XP_017448109.1

EC 7.6.2.2

XP_038963490.1

EC 7.6.2.2

XP_063142112.1

EC 7.6.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_181381.2 → NP_852046.1 broad substrate specificity ATP-binding cassette transporter ABCG2

See identical proteins and their annotated locations for NP_852046.1

Status: PROVISIONAL

Source sequence(s)

AY089997

UniProtKB/Swiss-Prot

Q80W57

Related

ENSRNOP00000009546.4, ENSRNOT00000009546.6

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

89006056..89132915

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063286042.1 → XP_063142112.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/Swiss-Prot

Q80ST1, Q80UR3, Q80W57, Q80XF3

UniProtKB/TrEMBL

A6K137
XM_006236576.4 → XP_006236638.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

See identical proteins and their annotated locations for XP_006236638.1

UniProtKB/Swiss-Prot

Q80ST1, Q80UR3, Q80W57, Q80XF3

UniProtKB/TrEMBL

A6K137

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_039107562.2 → XP_038963490.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/Swiss-Prot

Q80ST1, Q80UR3, Q80W57, Q80XF3

UniProtKB/TrEMBL

A6K137

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_006236573.5 → XP_006236635.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

See identical proteins and their annotated locations for XP_006236635.1

UniProtKB/Swiss-Prot

Q80ST1, Q80UR3, Q80W57, Q80XF3

UniProtKB/TrEMBL

A6K137

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein
XM_017592620.3 → XP_017448109.1 broad substrate specificity ATP-binding cassette transporter ABCG2 isoform X1

UniProtKB/Swiss-Prot

Q80ST1, Q80UR3, Q80W57, Q80XF3

UniProtKB/TrEMBL

A6K137

Conserved Domains (1) summary

TIGR00955
Location:46 → 651

3a01204; The Eye Pigment Precursor Transporter (EPP) Family protein