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Fbxw2 F-box and WD repeat domain containing 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311881, updated on 5-Mar-2024

Summary

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Official Symbol
Fbxw2provided by RGD
Official Full Name
F-box and WD repeat domain containing 2provided by RGD
Primary source
RGD:1310460
See related
Ensembl:ENSRNOG00000018687 AllianceGenome:RGD:1310460
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to be located in cytoplasm. Orthologous to human FBXW2 (F-box and WD repeat domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 156.3), Thymus (RPKM 147.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3p11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (38486358..38511683, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (18088859..18114387, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (13871513..13897033, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene heat shock protein family A (Hsp70) member 5 Neighboring gene Rab9 effector protein with kelch motifs Neighboring gene beta-1,3-galactosyltransferase 9 Neighboring gene proteasome 26S subunit, non-ATPase 5 Neighboring gene cutA divalent cation tolerance homolog-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10. Maruyama S, et al. Genomics, 2001 Dec. PMID 11735228
  2. Maturation of human dendritic cells is accompanied by functional remodelling of the ubiquitin-proteasome system. Ebstein F, et al. Int J Biochem Cell Biol, 2009 May. PMID 19028597
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
NOT located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
F-box/WD repeat-containing protein 2
Names
F-box and WD-40 domain protein 2
F-box and WD-40 domain-containing protein 2
protein MD6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107835.2 → NP_001101305.1  F-box/WD repeat-containing protein 2

    See identical proteins and their annotated locations for NP_001101305.1

    Status: PROVISIONAL

    Source sequence(s)
    BC166990
    UniProtKB/Swiss-Prot
    B2RZ17
    UniProtKB/TrEMBL
    A0A8L2QDA1
    Related
    ENSRNOP00000025399.5, ENSRNOT00000025399.5
    Conserved Domains (3) summary
    smart00256
    Location:60 → 94
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:151 → 185
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:140 → 447
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    38486358..38511683 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591849.3 → XP_017447338.1  F-box/WD repeat-containing protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8L2QDA1
    Conserved Domains (3) summary
    smart00256
    Location:87 → 121
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:178 → 212
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:167 → 442
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

  2. XM_006233976.3 → XP_006234038.1  F-box/WD repeat-containing protein 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ABP5, A0A8L2QDA1
    Related
    ENSRNOP00000090377.1
    Conserved Domains (3) summary
    smart00256
    Location:87 → 121
    FBOX; A Receptor for Ubiquitination Targets
    sd00039
    Location:178 → 212
    7WD40; WD40 repeat [structural motif]
    cl29593
    Location:167 → 474
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
B2RZ17.1 GenPept UniProtKB/Swiss-Prot:B2RZ17

Gene LinkOut

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