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Acss2 acyl-CoA synthetase short-chain family member 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311569, updated on 11-Apr-2024

Summary

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Official Symbol
Acss2provided by RGD
Official Full Name
acyl-CoA synthetase short-chain family member 2provided by RGD
Primary source
RGD:1305489
See related
Ensembl:ENSRNOG00000018755 AllianceGenome:RGD:1305489
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Acas2
Summary
Enables acetate-CoA ligase activity. Involved in acetate biosynthetic process and propionate biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in orofacial cleft. Orthologous to human ACSS2 (acyl-CoA synthetase short chain family member 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 882.3), Liver (RPKM 286.5) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Acss2 in Genome Data Viewer
Location:
3q42
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (164464124..164507607)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (144003808..144047452)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (151032925..151075856)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene U1 spliceosomal RNA Neighboring gene gamma-glutamyltransferase 7 Neighboring gene small nucleolar RNA SNORA18 Neighboring gene glutathione synthetase Neighboring gene myosin heavy chain 7B Neighboring gene microRNA 499a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Ketone body production is differentially altered in steatosis and non-alcoholic steatohepatitis in obese humans. Männistö VT, et al. Liver Int, 2015 Jul. PMID 25533197
  2. De novo lipogenesis in adipose tissue is associated with course of morbid obesity after bariatric surgery. Garrido-Sánchez L, et al. PLoS One, 2012. PMID 22384010, Free PMC Article
  3. SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats. Li Z, et al. Mol Neurobiol, 2022 Oct. PMID 35902549, Free PMC Article
  4. ACSS2 gene variant associated with cleft lip and palate in two independent Hispanic populations. Dodhia S, et al. Laryngoscope, 2017 Oct. PMID 28543373, Free PMC Article
  5. Using Whole Exome Sequencing to Identify Candidate Genes With Rare Variants In Nonsyndromic Cleft Lip and Palate. Aylward A, et al. Genet Epidemiol, 2016 Jul. PMID 27229527, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
    Title: SCFAs Ameliorate Chronic Postsurgical Pain-Related Cognition Dysfunction via the ACSS2-HDAC2 Axis in Rats.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables acetate-CoA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables acetate-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acetate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables propionate-CoA ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables transcription coactivator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in acetyl-CoA biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within acetyl-CoA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in lipid biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in long-term memory ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in propionate biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
acetyl-coenzyme A synthetase, cytoplasmic
Names
acetyl-Coenzyme A synthetase 2 (ADP forming)
NP_001101263.1
XP_006235383.3
XP_038961004.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107793.1 → NP_001101263.1  acetyl-coenzyme A synthetase, cytoplasmic

    See identical proteins and their annotated locations for NP_001101263.1

    Status: PROVISIONAL

    Source sequence(s)
    CH474050
    UniProtKB/TrEMBL
    A6KI41, B1WC11
    Related
    ENSRNOP00000059987.2, ENSRNOT00000064013.2
    Conserved Domains (1) summary
    cd05966
    Location:45 → 685
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    164464124..164507607
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039105076.2 → XP_038961004.1  acetyl-coenzyme A synthetase, cytoplasmic isoform X2

    UniProtKB/TrEMBL
    B1WC11
    Conserved Domains (1) summary
    cd05966
    Location:1 → 603
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)

  2. XM_006235321.5 → XP_006235383.3  acetyl-coenzyme A synthetase, cytoplasmic isoform X1

    UniProtKB/TrEMBL
    A0A8I6GJ11, G3V9U0
    Related
    ENSRNOP00000090627.1
    Conserved Domains (1) summary
    cd05966
    Location:89 → 742
    ACS; Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme)
Nucleotide Protein Strain
Heading Accession and Version

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