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eIF2Bepsilon eukaryotic translation initiation factor 2B subunit epsilon [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31156, updated on 4-Apr-2024

Summary

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Official Symbol
eIF2Bepsilonprovided by FlyBase
Official Full Name
eukaryotic translation initiation factor 2B subunit epsilonprovided by FlyBase
Primary source
FLYBASE:FBgn0023512
Locus tag
Dmel_CG3806
See related
AllianceGenome:FB:FBgn0023512
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3806; Dmel\CG3806; EG:86E4.1; eIF-2bepsilon; eIF2B-epsilon; elf2B-epsilon
Summary
Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in translational initiation. Predicted to be located in cytosol. Predicted to be part of eukaryotic translation initiation factor 2B complex. Is expressed in adult head. Human ortholog(s) of this gene implicated in leukoencephalopathy with vanishing white matter. Orthologous to human EIF2B5 (eukaryotic translation initiation factor 2B subunit epsilon). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
2B16-2B16; 1-0.2 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1920166..1922874, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (1814199..1816907, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43864 Neighboring gene ER degradation enhancer, mannosidase alpha-like 1 Neighboring gene Myb-interacting protein 130 Neighboring gene Rabconnectin-3B Neighboring gene Oculocerebrorenal syndrome of Lowe Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Phosphorylated seryl and threonyl, but not tyrosyl, residues are efficient specificity determinants for GSK-3beta and Shaggy. Williams DD, et al. FEBS Lett, 1999 Apr 1. PMID 10217415
  2. Characterization of the initiation factor eIF2B and its regulation in Drosophila melanogaster. Williams DD, et al. J Biol Chem, 2001 Feb 9. PMID 11060303
  3. Translational induction of ATF4 during integrated stress response requires noncanonical initiation factors eIF2D and DENR. Vasudevan D, et al. Nat Commun, 2020 Sep 16. PMID 32938929, Free PMC Article
  4. The Drosophila MSL complex activates the transcription of target genes. Straub T, et al. Genes Dev, 2005 Oct 1. PMID 16204179, Free PMC Article
  5. Extensive use of RNA-binding proteins in Drosophila sensory neuron dendrite morphogenesis. Olesnicky EC, et al. G3 (Bethesda), 2014 Feb 19. PMID 24347626, Free PMC Article

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
  
enables translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables translation initiation factor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation initiation factor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in translational initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 2B complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
part_of eukaryotic translation initiation factor 2B complex TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
eukaryotic translation initiation factor 2B subunit epsilon
Names
CG3806-PA
CG3806-PB
eIF2B-epsilon
eIF2Bepsilon-PA
eIF2Bepsilon-PB
NP_569961.2
NP_996329.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1920166..1922874 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_206606.3 → NP_996329.1  eukaryotic translation initiation factor 2B subunit epsilon, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996329.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46090, Q9W541
    Conserved Domains (4) summary
    cd04197
    Location:9 → 223
    eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    cd11558
    Location:499 → 659
    W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
    COG1208
    Location:22 → 409
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:326 → 397
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. NM_130605.5 → NP_569961.2  eukaryotic translation initiation factor 2B subunit epsilon, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569961.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O46090, Q9W541
    Related
    FBpp0070336
    Conserved Domains (4) summary
    cd04197
    Location:9 → 223
    eIF-2B_epsilon_N; The N-terminal domain of epsilon subunit of the eIF-2B is a subfamily of glycosyltransferase 2
    cd11558
    Location:499 → 659
    W2_eIF2B_epsilon; C-terminal W2 domain of eukaryotic translation initiation factor 2B epsilon
    COG1208
    Location:22 → 409
    GCD1; NDP-sugar pyrophosphorylase, includes eIF-2Bgamma, eIF-2Bepsilon, and LPS biosynthesis proteins [Translation, ribosomal structure and biogenesis, Cell wall/membrane/envelope biogenesis]
    cl00160
    Location:326 → 397
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9GQ87 Q9GQ87
Q9W541 Q9W541

Gene LinkOut

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