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Pdhx pyruvate dehydrogenase complex, component X [ Rattus norvegicus (Norway rat) ]

Gene ID: 311254, updated on 13-Apr-2024

Summary

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Official Symbol
Pdhxprovided by RGD
Official Full Name
pyruvate dehydrogenase complex, component Xprovided by RGD
Primary source
RGD:1566332
See related
Ensembl:ENSRNOG00000006947 AllianceGenome:RGD:1566332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ac1164
Summary
Predicted to enable acyltransferase activity. Predicted to contribute to pyruvate dehydrogenase (NAD+) activity. Predicted to be involved in acetyl-CoA biosynthetic process from pyruvate. Predicted to be located in mitochondrial matrix. Predicted to be part of pyruvate dehydrogenase complex. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in pyruvate decarboxylase deficiency. Orthologous to human PDHX (pyruvate dehydrogenase complex component X). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 312.1), Muscle (RPKM 244.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q32
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (109826579..109886869, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (89372248..89431779, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (92910300..92933725, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein S8, pseudogene 15 Neighboring gene uncharacterized LOC120101453 Neighboring gene uncharacterized LOC134486131 Neighboring gene APAF1 interacting protein Neighboring gene RNA, U6 small nuclear 434

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A phase II study of ENMD-2076 in advanced soft tissue sarcoma (STS). Veitch Z, et al. Sci Rep, 2019 May 14. PMID 31089155, Free PMC Article
  2. Dihydrolipoamide dehydrogenase-binding protein of the human pyruvate dehydrogenase complex. DNA-derived amino acid sequence, expression, and reconstitution of the pyruvate dehydrogenase complex. Harris RA, et al. J Biol Chem, 1997 Aug 8. PMID 9242632
  3. Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity. Mathias RA, et al. Cell, 2014 Dec 18. PMID 25525879, Free PMC Article
  4. Regulation of mammalian pyruvate dehydrogenase complex by phosphorylation: complexity of multiple phosphorylation sites and kinases. Patel MS, et al. Exp Mol Med, 2001 Dec 31. PMID 11795479
  5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to pyruvate dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA biosynthetic process from pyruvate ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of pyruvate dehydrogenase complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
pyruvate dehydrogenase protein X component, mitochondrial
NP_001381465.1
XP_063139776.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001394536.1 → NP_001381465.1  pyruvate dehydrogenase protein X component, mitochondrial

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/TrEMBL
    A0A8I6ATI8
    Related
    ENSRNOP00000071052.2, ENSRNOT00000088242.2
    Conserved Domains (1) summary
    TIGR01349
    Location:57 → 501
    PDHac_trf_mito; pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    109826579..109886869 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283706.1 → XP_063139776.1  pyruvate dehydrogenase protein X component, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A0G2JZH8

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001044242.1: Suppressed sequence

    Description
    NM_001044242.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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