U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Ctnnd1 catenin delta 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 311163, updated on 3-Apr-2024

Summary

Go to the top of the page Help
Official Symbol
Ctnnd1provided by RGD
Official Full Name
catenin delta 1provided by RGD
Primary source
RGD:1305643
See related
Ensembl:ENSRNOG00000030790 AllianceGenome:RGD:1305643
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P120; Catns
Summary
Enables cell adhesion molecule binding activity and protein kinase binding activity. Involved in brain development. Located in several cellular components, including growth cone; lamellipodium; and zonula adherens. Is active in several cellular components, including Schaffer collateral - CA1 synapse; hippocampal mossy fiber to CA3 synapse; and postsynaptic density, intracellular component. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in blepharocheilodontic syndrome 2. Orthologous to human CTNND1 (catenin delta 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 503.6), Adrenal (RPKM 458.1) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
3q24
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (90090025..90141247, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (69683328..69734550, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (72001904..72053047, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486404 Neighboring gene uncharacterized LOC108350412 Neighboring gene BTB domain containing 18 Neighboring gene selenoprotein H

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. A delta-catenin signaling pathway leading to dendritic protrusions. Abu-Elneel K, et al. J Biol Chem, 2008 Nov 21. PMID 18809680
  2. Distribution of adherens junction mediated by VE-cadherin complex in rat spleen sinus endothelial cells. Uehara K. Cell Tissue Res, 2006 Mar. PMID 16244888
  3. Differential expression of p120 catenin in glial cells of the adult rat brain. Chauvet N, et al. J Comp Neurol, 2004 Nov 1. PMID 15389614
  4. Distribution of p120 catenin during rat brain development: potential role in regulation of cadherin-mediated adhesion and actin cytoskeleton organization. Chauvet N, et al. Mol Cell Neurosci, 2003 Apr. PMID 12727444
  5. The catenin, p120ctn, is a common membrane-associated protein in various epithelial and non-epithelial cells and tissues. Golenhofen N, et al. Histochem Cell Biol, 2000 Aug. PMID 11052263

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Decreased expression of p120-catenin was detected in intracranial aneurysm endothelium.
    Title: Role of Vascular Endothelial-Cadherin and p120-Catenin in the Formation of Experimental Intracranial Aneurysm in Animals.
  2. GSK-3 interacts with and phosphorylates delta-catenin and thereby negatively affects its stability by enabling its ubiquitination/proteosome-mediated proteolysis
    Title: GSK-3 phosphorylates delta-catenin and negatively regulates its stability via ubiquitination/proteosome-mediated proteolysis.
  3. the delta-catenin signaling pathway leads to dendritic protrusions
    Title: A delta-catenin signaling pathway leading to dendritic protrusions.
  4. Results indicate that a presynaptic signaling pathway through p120ctn, Fer, SHP-2, and beta-catenin promotes excitatory synapse development and function.
    Title: Synapses are regulated by the cytoplasmic tyrosine kinase Fer in a pathway mediated by p120catenin, Fer, SHP-2, and beta-catenin.
  5. Expression of p120ctn in oligodendrocyte lineage cells suggests that p120ctn may participate in oligodendrogenesis and myelination. Subcellular distribution of p120ctn suggests that it may serve multiple functions in the CNS.
    Title: Differential expression of p120 catenin in glial cells of the adult rat brain.
Submit: New GeneRIF Correction

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding ISO
Inferred from Sequence Orthology
more info
  
enables cell adhesion molecule binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein phosphatase binding ISO
Inferred from Sequence Orthology
more info
  
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
  
enables protein tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell-cell adhesion mediated by cadherin ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within epithelial cell differentiation involved in salivary gland development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glomerulus morphogenesis ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within kidney development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within morphogenesis of a polarized epithelium ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine autophosphorylation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein processing ISO
Inferred from Sequence Orthology
more info
  
involved_in protein stabilization ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within salivary gland morphogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in adherens junction ISO
Inferred from Sequence Orthology
more info
  
located_in apicolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
  
part_of catenin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cell-cell junction ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in dendritic spine IDA
Inferred from Direct Assay
more info
 PubMed 
part_of flotillin complex ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growth cone IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium IDA
Inferred from Direct Assay
more info
 PubMed 
located_in lamellipodium ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in midbody ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in postsynaptic density, intracellular component IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynaptic active zone cytoplasmic component IDA
Inferred from Direct Assay
more info
 PubMed 
located_in zonula adherens IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
catenin delta-1
Names
catenin (cadherin associated protein), delta 1
catenin src
p120 catenin

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107740.1 → NP_001101210.1  catenin delta-1

    See identical proteins and their annotated locations for NP_001101210.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473949
    UniProtKB/TrEMBL
    A0A8I5ZVG2, A6HMQ5
    Related
    ENSRNOP00000082894.1, ENSRNOT00000097596.1
    Conserved Domains (3) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    90090025..90141247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063283650.1 → XP_063139720.1  catenin delta-1 isoform X13

    UniProtKB/TrEMBL
    A6HMQ4

  2. XM_039104873.2 → XP_038960801.1  catenin delta-1 isoform X6

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (3) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  3. XM_063283649.1 → XP_063139719.1  catenin delta-1 isoform X10

  4. XM_063283647.1 → XP_063139717.1  catenin delta-1 isoform X4

  5. XM_039104871.2 → XP_038960799.1  catenin delta-1 isoform X3

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (3) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  6. XM_039104877.2 → XP_038960805.1  catenin delta-1 isoform X12

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  7. XM_039104876.2 → XP_038960804.1  catenin delta-1 isoform X11

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  8. XM_039104872.2 → XP_038960800.1  catenin delta-1 isoform X5

    UniProtKB/TrEMBL
    D3ZZZ9
    Related
    ENSRNOP00000063519.2
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  9. XM_039104875.2 → XP_038960803.1  catenin delta-1 isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZVG2
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  10. XM_039104874.2 → XP_038960802.1  catenin delta-1 isoform X7

    UniProtKB/TrEMBL
    A0A8I5ZVG2
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  11. XM_039104870.2 → XP_038960798.1  catenin delta-1 isoform X2

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (4) summary
    smart00185
    Location:397 → 437
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:632 → 740
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]
    pfam00514
    Location:440 → 481
    Arm; Armadillo/beta-catenin-like repeat

  12. XM_006234453.5 → XP_006234515.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006234515.1

    UniProtKB/TrEMBL
    A0A0G2JXM1, D3ZZZ9
    Conserved Domains (2) summary
    cd00020
    Location:363 → 481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]

  13. XM_039104878.2 → XP_038960806.1  catenin delta-1 isoform X14

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (3) summary
    smart00185
    Location:296 → 336
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:531 → 639
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:267 → 292
    ARM; armadillo repeat [structural motif]

  14. XM_008761987.4 → XP_008760209.1  catenin delta-1 isoform X14

    UniProtKB/TrEMBL
    D3ZZZ9
    Conserved Domains (3) summary
    smart00185
    Location:296 → 336
    ARM; Armadillo/beta-catenin-like repeats
    cd13394
    Location:531 → 639
    Syo1_like; Fungal symportin 1 (syo1) and similar proteins
    sd00043
    Location:267 → 292
    ARM; armadillo repeat [structural motif]

  15. XM_006234452.5 → XP_006234514.1  catenin delta-1 isoform X1

    See identical proteins and their annotated locations for XP_006234514.1

    UniProtKB/TrEMBL
    A0A0G2JXM1, D3ZZZ9
    Related
    ENSRNOP00000070326.2
    Conserved Domains (2) summary
    cd00020
    Location:363 → 481
    ARM; Armadillo/beta-catenin-like repeats. An approximately 40 amino acid long tandemly repeated sequence motif first identified in the Drosophila segment polarity gene armadillo; these repeats were also found in the mammalian armadillo homolog beta-catenin, ...
    sd00043
    Location:368 → 393
    ARM; armadillo repeat [structural motif]

  16. XM_063283648.1 → XP_063139718.1  catenin delta-1 isoform X9

    UniProtKB/TrEMBL
    A6HMQ5
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous