Itga4 integrin subunit alpha 4 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itga4provided by RGD
Official Full Name: integrin subunit alpha 4provided by RGD
Primary source: RGD:1593249
See related: Ensembl:ENSRNOG00000004861 AllianceGenome:RGD:1593249
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables cell adhesion molecule binding activity; fibronectin binding activity; and protein antigen binding activity. Involved in several processes, including clathrin-dependent extracellular exosome endocytosis; neuron projection morphogenesis; and regulation of leukocyte migration. Located in several cellular components, including extracellular exosome; growth cone; and neuronal cell body. Used to study anti-basement membrane glomerulonephritis; diabetic retinopathy; nephritis; and pneumonia. Biomarker of pre-eclampsia. Human ortholog(s) of this gene implicated in autism spectrum disorder and pancreatic cancer. Orthologous to human ITGA4 (integrin subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 728.4), Thymus (RPKM 421.8) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q24

Exon count:: 30

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (84569487..84646276)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (64162764..64235010)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (66178745..66265547)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
Title: Dahuang Zhechong pill attenuates hepatic sinusoidal capillarization in liver cirrhosis and hepatocellular carcinoma rat model via the MK/integrin signaling pathway.
Mesenchymal stem cell aggregation mediated by integrin alpha4/VCAM-1 after intrathecal transplantation in MCAO rats.
Title: Mesenchymal stem cell aggregation mediated by integrin α4/VCAM-1 after intrathecal transplantation in MCAO rats.
investigate the effects of the connecting segment-1 (CS-1) peptide therapy, which blocks FN-alpha4beta1 integrin leukocyte interactions, in a well-established model of 24-h cold liver ischemia-reperfusion injury
Title: Fibronectin-α4β1 interactions in hepatic cold ischemia and reperfusion injury: regulation of MMP-9 and MT1-MMP via the p38 MAPK pathway.
Blockade of integrin alpha4beta1 significantly inhibits the migration of activated CCR4-negative CD4 T cells to all of the inflammatory stimuli.
Title: Differing requirements for CCR4, E-selectin, and α4β1 for the migration of memory CD4 and activated T cells to dermal inflammation.
Data describe the effects of anti-alpha4 mAb binding on neutrophil activation, function and anti-alpha4-mAb/alpha4beta1-integrin-complex internalization.
Title: Anti-alpha4beta1 integrin antibody induces receptor internalization and does not impair the function of circulating neutrophilic leukocytes.
these data suggest that SLAYGLR-mediated alpha(4)beta(1) and alpha(9)beta(1) integrin signaling may be responsible for higher hepatic neutrophil infiltration and higher liver injury in the rat alcoholic steatohepatitis (ASH)model
Title: Interaction of osteopontin with neutrophil alpha(4)beta(1) and alpha(9)beta(1) integrins in a rodent model of alcoholic liver disease.
We establish the importance of the alpha4 integrin-paxillin interaction in a model of axonal regeneration and highlight differing dependence on phosphorylation of alpha4 for extension of neuronal growth cones and migration of non-neural cells.
Title: Neurite outgrowth on a fibronectin isoform expressed during peripheral nerve regeneration is mediated by the interaction of paxillin with alpha4beta1 integrins.
interactions between fibronectin and its integrin alpha 4 beta 1 receptor is important in the development of ischemia/reperfusion injury of steatotic liver transplants
Title: Fibronectin-alpha 4 beta 1 integrin-mediated blockade protects genetically fat Zucker rat livers from ischemia/reperfusion injury.
alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine
Title: alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor.
Results are consistent with a role for the integrin alpha4beta1--vascular cell adhesion molecule-1 interaction in extension of sympathetic axons into the myocardium.
Title: Expression and function of integrin alpha4beta1 and vascular cell adhesion molecule-1 (VCAM-1) during sympathetic innervation of the heart.

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General gene information

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Markers

Itga4 (e-PCR), detects polymorphism
- UniSTS:507002

RH142630 (e-PCR)
- UniSTS:231877

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
contributes_to C-X3-C chemokine binding	ISO Inferred from Sequence Orthology more info
enables antigen binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables cell adhesion molecule binding	ISO Inferred from Sequence Orthology more info
enables fibronectin binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables fibronectin binding	ISO Inferred from Sequence Orthology more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein antigen binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within T cell migration	ISO Inferred from Sequence Orthology more info
involved_in axonogenesis involved in innervation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion mediated by integrin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion in response to extracellular stimulus	ISO Inferred from Sequence Orthology more info
involved_in cell-cell adhesion mediated by integrin	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-matrix adhesion	ISO Inferred from Sequence Orthology more info
involved_in cell-matrix adhesion involved in ameboidal cell migration	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amyloid-beta	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cytokine stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within chorio-allantoic fusion	ISO Inferred from Sequence Orthology more info
involved_in clathrin-dependent extracellular exosome endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in diapedesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endodermal cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within face development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heart development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules	ISO Inferred from Sequence Orthology more info
involved_in heterotypic cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in import into cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in integrin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte cell-cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in leukocyte tethering or rolling	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of vasoconstriction	ISO Inferred from Sequence Orthology more info
involved_in neuron projection extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pericyte cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte cell-cell adhesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of leukocyte tethering or rolling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in receptor clustering	ISO Inferred from Sequence Orthology more info
involved_in substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within vascular associated smooth muscle cell migration	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in growth cone	IDA Inferred from Direct Assay more info	PubMed
part_of integrin alpha4-beta7 complex	ISO Inferred from Sequence Orthology more info
part_of integrin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: integrin alpha-4

Names: integrin, alpha 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.