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Nmi N-myc (and STAT) interactor [ Rattus norvegicus (Norway rat) ]

Gene ID: 311021, updated on 5-Mar-2024

Summary

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Official Symbol
Nmiprovided by RGD
Official Full Name
N-myc (and STAT) interactorprovided by RGD
Primary source
RGD:1311721
See related
Ensembl:ENSRNOG00000027502 AllianceGenome:RGD:1311721
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable identical protein binding activity. Predicted to be involved in several processes, including macrophage activation involved in immune response; positive regulation of defense response; and regulation of NIK/NF-kappaB signaling. Predicted to act upstream of or within negative regulation of innate immune response; negative regulation of type I interferon production; and positive regulation of protein K48-linked ubiquitination. Predicted to be located in several cellular components, including cytosol; extracellular space; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NMI (N-myc and STAT interactor). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 288.2), Thymus (RPKM 244.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
3q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (56824778..56848891, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (36415607..36439716, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (37458891..37480984, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L28, pseudogene 9 Neighboring gene RNA binding motif protein 43 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta), pseudogene 2 Neighboring gene chaperonin containing Tcp1, subunit 8 (theta), pseudogene 3 Neighboring gene lactate dehydrogenase A, pseudogene 11 Neighboring gene TNF alpha induced protein 6

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells. Brozzi F, et al. J Biol Chem, 2014 Jul 25. PMID 24936061, Free PMC Article
  2. Negative regulation of Nmi on virus-triggered type I IFN production by targeting IRF7. Wang J, et al. J Immunol, 2013 Sep 15. PMID 23956435
  3. Nmi protein interacts with regions that differ between MycN and Myc and is localized in the cytoplasm of neuroblastoma cells in contrast to nuclear MycN. Bannasch D, et al. Oncogene, 1999 Nov 18. PMID 10597290
  4. Next-generation sequencing to generate interactome datasets. Yu H, et al. Nat Methods, 2011 Jun. PMID 21516116, Free PMC Article
  5. A proteome-scale map of the human interactome network. Rolland T, et al. Cell, 2014 Nov 20. PMID 25416956, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. identified NMI induction as a novel negative feedback mechanism that decreases IRE1alpha-dependent activation of JNK and apoptosis in cytokine-exposed beta cells
    Title: A combined "omics" approach identifies N-Myc interactor as a novel cytokine-induced regulator of IRE1 protein and c-Jun N-terminal kinase in pancreatic beta cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC112791

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in macrophage activation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interferon-alpha production ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of non-canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in response to virus ISO
Inferred from Sequence Orthology
more info
  
involved_in toll-like receptor 4 signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
N-myc-interactor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034148.1 → NP_001029320.1  N-myc-interactor

    See identical proteins and their annotated locations for NP_001029320.1

    Status: PROVISIONAL

    Source sequence(s)
    BC100089
    UniProtKB/TrEMBL
    Q498S7
    Related
    ENSRNOP00000035928.5, ENSRNOT00000030373.5
    Conserved Domains (2) summary
    pfam07292
    Location:170 → 258
    NID; Nmi/IFP 35 domain (NID)
    pfam07334
    Location:1 → 71
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    56824778..56848891 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039104811.2 → XP_038960739.1  N-myc-interactor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A371, A6JF14
    Conserved Domains (2) summary
    pfam07334
    Location:27 → 102
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:201 → 289
    NID; Nmi/IFP 35 domain (NID)

  2. XM_039104813.2 → XP_038960741.1  N-myc-interactor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A371, A6JF14
    Conserved Domains (2) summary
    pfam07334
    Location:27 → 102
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:201 → 289
    NID; Nmi/IFP 35 domain (NID)

  3. XM_039104814.2 → XP_038960742.1  N-myc-interactor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A371, A6JF14
    Conserved Domains (2) summary
    pfam07334
    Location:27 → 102
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:201 → 289
    NID; Nmi/IFP 35 domain (NID)

  4. XM_039104812.2 → XP_038960740.1  N-myc-interactor isoform X1

    UniProtKB/TrEMBL
    A0A8I6A371, A6JF14
    Related
    ENSRNOP00000086226.1
    Conserved Domains (2) summary
    pfam07334
    Location:27 → 102
    IFP_35_N; Interferon-induced 35 kDa protein (IFP 35) N-terminus
    pfam07292
    Location:201 → 289
    NID; Nmi/IFP 35 domain (NID)
Nucleotide Protein Strain
Heading Accession and Version

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