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Adh6 alcohol dehydrogenase 6 (class V) [ Rattus norvegicus (Norway rat) ]

Gene ID: 310903, updated on 11-Apr-2024

Summary

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Official Symbol
Adh6provided by RGD
Official Full Name
alcohol dehydrogenase 6 (class V)provided by RGD
Primary source
RGD:1306313
See related
Ensembl:ENSRNOG00000069176 AllianceGenome:RGD:1306313
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable NAD-retinol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; and zinc ion binding activity. Predicted to be involved in ethanol oxidation; retinoic acid metabolic process; and retinol metabolic process. Predicted to be active in cytosol. Orthologous to human ADH6 (alcohol dehydrogenase 6 (class V)). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward (RPKM 567.1) See more
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Genomic context

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Location:
2q44
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (229576612..229608359)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (226903208..226934564)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (243656568..243687857)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alcohol dehydrogenase 6A (class V) Neighboring gene alcohol dehydrogenase 1C (class I), gamma polypeptide, pseudogene 1 Neighboring gene uncharacterized LOC108350123 Neighboring gene uncharacterized LOC134485688 Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Enzymatic properties of the protein encoded by newly cloned human alcohol dehydrogenase ADH6 gene. Chen CS, et al. Biochem Biophys Res Commun, 1991 Dec 16. PMID 1755855
  2. Human liver alcohol dehydrogenase: purification, composition, and catalytic features. Lange LG, et al. Biochemistry, 1976 Oct 19. PMID 9982
  3. Large-scale proteomics and phosphoproteomics of urinary exosomes. Gonzales PA, et al. J Am Soc Nephrol, 2009 Feb. PMID 19056867, Free PMC Article
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables alcohol dehydrogenase (NAD+) activity ISO
Inferred from Sequence Orthology
more info
  
enables alcohol dehydrogenase (NAD+) activity, zinc-dependent IBA
Inferred from Biological aspect of Ancestor
more info
  
enables all-trans-retinol dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in response to ethanol IEA
Inferred from Electronic Annotation
more info
  
involved_in response to ethanol ISO
Inferred from Sequence Orthology
more info
  
involved_in retinoic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in retinol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
alcohol dehydrogenase 6
Names
class V alcohol dehydrogenase
NP_001012084.1
XP_006233436.1
XP_017446428.1
XP_038958396.1
XP_063138044.1
XP_063138045.1
XP_063138046.1
XP_063138047.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012084.1 → NP_001012084.1  alcohol dehydrogenase 6

    See identical proteins and their annotated locations for NP_001012084.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083792
    UniProtKB/Swiss-Prot
    Q5XI95
    UniProtKB/TrEMBL
    A0A8I6A108
    Related
    ENSRNOP00000084312.1, ENSRNOT00000096969.1
    Conserved Domains (2) summary
    cd08299
    Location:3 → 376
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
    COG1062
    Location:8 → 374
    FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    229576612..229608359
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281974.1 → XP_063138044.1  alcohol dehydrogenase 6 isoform X1

    UniProtKB/TrEMBL
    A0A8I6ATS6

  2. XM_063281976.1 → XP_063138046.1  alcohol dehydrogenase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLG2

  3. XM_063281975.1 → XP_063138045.1  alcohol dehydrogenase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLG2

  4. XM_006233374.3 → XP_006233436.1  alcohol dehydrogenase 6 isoform X3

    See identical proteins and their annotated locations for XP_006233436.1

    UniProtKB/TrEMBL
    A0A8I6A108, A0A8L2QGL3
    Related
    ENSRNOP00000030638.5
    Conserved Domains (2) summary
    cd08299
    Location:20 → 389
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases
    COG1062
    Location:21 → 387
    FrmA; Zn-dependent alcohol dehydrogenase [General function prediction only]

  5. XM_063281977.1 → XP_063138047.1  alcohol dehydrogenase 6 isoform X4

  6. XM_017590939.3 → XP_017446428.1  alcohol dehydrogenase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLG2, A0A8I6A108
    Related
    ENSRNOP00000078781.1
    Conserved Domains (1) summary
    cd08299
    Location:22 → 392
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

  7. XM_039102468.2 → XP_038958396.1  alcohol dehydrogenase 6 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZLG2, A0A8I6A108
    Conserved Domains (1) summary
    cd08299
    Location:22 → 392
    alcohol_DH_class_I_II_IV; class I, II, IV alcohol dehydrogenases

RNA

  1. XR_010063619.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XI95.1 GenPept UniProtKB/Swiss-Prot:Q5XI95

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