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Tifa TRAF-interacting protein with forkhead-associated domain [ Rattus norvegicus (Norway rat) ]

Gene ID: 310877, updated on 5-Mar-2024

Summary

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Official Symbol
Tifaprovided by RGD
Official Full Name
TRAF-interacting protein with forkhead-associated domainprovided by RGD
Primary source
RGD:1359151
See related
Ensembl:ENSRNOG00000010941 AllianceGenome:RGD:1359151
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
T2bp; Ab2-389
Summary
Predicted to be involved in several processes, including intracellular signal transduction; positive regulation of I-kappaB kinase/NF-kappaB signaling; and protein homooligomerization. Predicted to be active in cytoplasm. Orthologous to human TIFA (TRAF interacting protein with forkhead associated domain). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 137.4), Lung (RPKM 50.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q42
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (218927724..218942111)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (216257926..216267635)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (232104394..232137425)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene alpha-kinase 1 Neighboring gene ribosomal protein L29, pseudogene 5 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3 like 2 Neighboring gene adaptor-related protein complex 1 associated regulatory protein Neighboring gene transfer RNA alanine (anticodon AGC) 70 Neighboring gene family with sequence similarity 241 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. INNATE IMMUNITY. Cytosolic detection of the bacterial metabolite HBP activates TIFA-dependent innate immunity. Gaudet RG, et al. Science, 2015 Jun 12. PMID 26068852
  2. ALPK1- and TIFA-Dependent Innate Immune Response Triggered by the Helicobacter pylori Type IV Secretion System. Zimmermann S, et al. Cell Rep, 2017 Sep 5. PMID 28877472
  3. ALPK1 controls TIFA/TRAF6-dependent innate immunity against heptose-1,7-bisphosphate of gram-negative bacteria. Milivojevic M, et al. PLoS Pathog, 2017 Feb. PMID 28222186, Free PMC Article
  4. Intermolecular binding between TIFA-FHA and TIFA-pT mediates tumor necrosis factor alpha stimulation and NF-κB activation. Huang CC, et al. Mol Cell Biol, 2012 Jul. PMID 22566686, Free PMC Article
  5. Alpha-kinase 1 is a cytosolic innate immune receptor for bacterial ADP-heptose. Zhou P, et al. Nature, 2018 Sep. PMID 30111836

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Process Evidence Code Pubs
involved_in canonical NF-kappaB signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in cytoplasmic pattern recognition receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in innate immune response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of canonical NF-kappaB signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization ISO
Inferred from Sequence Orthology
more info
  
involved_in protein homooligomerization ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
TRAF-interacting protein with FHA domain-containing protein A
Names
TRAF2-binding protein
Traf2 binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014044.1 → NP_001014066.1  TRAF-interacting protein with FHA domain-containing protein A

    See identical proteins and their annotated locations for NP_001014066.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083765
    UniProtKB/Swiss-Prot
    Q5XIB9
    UniProtKB/TrEMBL
    A6HVM2
    Related
    ENSRNOP00000061870.1, ENSRNOT00000014533.7
    Conserved Domains (1) summary
    cd00060
    Location:47 → 129
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    218927724..218942111
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039102464.2 → XP_038958392.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

    UniProtKB/Swiss-Prot
    Q5XIB9
    UniProtKB/TrEMBL
    A6HVM2
    Conserved Domains (1) summary
    cd00060
    Location:47 → 129
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

  2. XM_039102463.2 → XP_038958391.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

    UniProtKB/Swiss-Prot
    Q5XIB9
    UniProtKB/TrEMBL
    A6HVM2
    Related
    ENSRNOP00000077082.1
    Conserved Domains (1) summary
    cd00060
    Location:47 → 129
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

  3. XM_039102465.2 → XP_038958393.1  TRAF-interacting protein with FHA domain-containing protein A isoform X1

    UniProtKB/Swiss-Prot
    Q5XIB9
    UniProtKB/TrEMBL
    A6HVM2
    Conserved Domains (1) summary
    cd00060
    Location:47 → 129
    FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...

RNA

  1. XR_010063617.1 RNA Sequence

  2. XR_010063618.1 RNA Sequence

  3. XR_005500306.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XIB9.1 GenPept UniProtKB/Swiss-Prot:Q5XIB9

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