Ngf nerve growth factor [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ngfprovided by RGD
Official Full Name: nerve growth factorprovided by RGD
Primary source: RGD:1598328
See related: Ensembl:ENSRNOG00000016571 AllianceGenome:RGD:1598328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ngfb; beta-NGF
Summary: Predicted to enable nerve growth factor receptor binding activity; peptidase regulator activity; and signaling receptor activator activity. Involved in several processes, including negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; and response to ozone. Acts upstream of or within positive regulation of DNA-binding transcription factor activity; positive regulation of neurotrophin TRK receptor signaling pathway; and positive regulation of protein autophosphorylation. Located in extracellular space. Used to study bladder neck obstruction; cystitis; degenerative disc disease; and neurogenic bladder. Biomarker of several diseases, including diabetic neuropathy; hyperhomocysteinemia; mental depression; myofascial pain syndrome; and respiratory syncytial virus infectious disease. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; asthma; end stage renal disease; hereditary sensory and autonomic neuropathy type 5; and interstitial cystitis. Orthologous to human NGF (nerve growth factor). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 38.8), Spleen (RPKM 21.4) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q34

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (192589580..192642971)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (189901058..189954452)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (204886158..204939523)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway.
Title: Improvement of diabetes-induced spinal cord axon injury with taurine via nerve growth factor-dependent Akt/mTOR pathway.
NGF contributes to activities of acid-sensing ion channels in dorsal root ganglion neurons of male rats with experimental peripheral artery disease.
Title: NGF contributes to activities of acid-sensing ion channels in dorsal root ganglion neurons of male rats with experimental peripheral artery disease.
Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment.
Title: Synthesis and secretion of Nerve Growth Factor is regulated by Nitric Oxide in bladder cells in vitro under a hyperglycemic environment.
Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA.
Title: Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA.
NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release.
Title: NGF-Induced Upregulation of CGRP in Orofacial Pain Induced by Tooth Movement Is Dependent on Atp6v0a1 and Vesicle Release.
Deleterious impact of nerve growth factor precursor (proNGF) on bladder urothelial and smooth muscle cells.
Title: Deleterious impact of nerve growth factor precursor (proNGF) on bladder urothelial and smooth muscle cells.
Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Title: Small Endogenous Ligands Modulation of Nerve Growth Factor Bioactivity: A Structural Biology Overview.
Nerve Growth Factor in Breast Cancer Cells Promotes Axonal Growth and Expression of Calcitonin Gene-related Peptide in a Rat Model of Spinal Metastasis.
Title: Nerve Growth Factor in Breast Cancer Cells Promotes Axonal Growth and Expression of Calcitonin Gene-related Peptide in a Rat Model of Spinal Metastasis.
Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.
Title: Nerve Growth Factor: A Dual Activator of Noradrenergic and Cholinergic Systems of the Rat Ovary.
The Involvement of Insulin-Like Growth Factor 1 and Nerve Growth Factor in Alzheimer's Disease-Like Pathology and Survival Role of the Mix of Embryonic Proteoglycans: Electrophysiological Fingerprint, Structural Changes and Regulatory Effects on Neurotrophins.
Title: The Involvement of Insulin-Like Growth Factor 1 and Nerve Growth Factor in Alzheimer's Disease-Like Pathology and Survival Role of the Mix of Embryonic Proteoglycans: Electrophysiological Fingerprint, Structural Changes and Regulatory Effects on Neurotrophins.

Submit: New GeneRIF Correction See all GeneRIFs (196)

General gene information

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Markers

PMC20267P1 (e-PCR)
- UniSTS:271892

NGFB (e-PCR)
- UniSTS:503833

RH142206 (e-PCR)
- UniSTS:231456

NoName (e-PCR)
- UniSTS:486722

NoName (e-PCR)
- UniSTS:495208

NGFB (e-PCR)
- UniSTS:264122

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cysteine-type endopeptidase activator activity involved in apoptotic process	ISO Inferred from Sequence Orthology more info
enables death receptor agonist activity	ISO Inferred from Sequence Orthology more info
enables growth factor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables metalloendopeptidase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables metalloendopeptidase inhibitor activity	ISS Inferred from Sequence or Structural Similarity more info
enables nerve growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables nerve growth factor receptor binding	IEA Inferred from Electronic Annotation more info
enables nerve growth factor receptor binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in adult locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of axon extension	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell proliferation in forebrain	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway in absence of ligand	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IEA Inferred from Electronic Annotation more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
involved_in memory	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in modulation of chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of neuron apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nerve development	IBA Inferred from Biological aspect of Ancestor more info
involved_in nerve growth factor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nerve growth factor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuron projection development	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in neuron projection morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neuron projection morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within peripheral nervous system development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ERK1 and ERK2 cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of Ras protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of axon extension	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of collateral sprouting	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of neuron maturation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron projection development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of protein ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of neurotransmitter secretion	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in response to electrical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to glucocorticoid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to mechanical stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to nicotine	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ozone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in sensory perception of hot stimulus	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sensory perception of pain	ISO Inferred from Sequence Orthology more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in endosome lumen	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in synaptic vesicle	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: beta-nerve growth factor

Names: nerve growth factor (beta polypeptide); pro-nerve growth factor long

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001277055.1 → NP_001263984.1 beta-nerve growth factor precursor

See identical proteins and their annotated locations for NP_001263984.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/Swiss-Prot

P25427

UniProtKB/TrEMBL

A0A8I6A8J2, A6K3I9

Related

ENSRNOP00000022200.5, ENSRNOT00000022200.7

Conserved Domains (1) summary

pfam00243
Location:128 → 237

NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

192589580..192642971

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063281907.1 → XP_063137977.1 beta-nerve growth factor isoform X2

UniProtKB/Swiss-Prot

P25427

UniProtKB/TrEMBL

A6K3I9
XM_039102402.2 → XP_038958330.1 beta-nerve growth factor isoform X1

UniProtKB/TrEMBL

A0A0G2K2Z7, A0A8I6AA86

Conserved Domains (1) summary

pfam00243
Location:180 → 289

NGF; Nerve growth factor family