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Cdc45 Cell division cycle 45 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 31052, updated on 4-Apr-2024

Summary

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Official Symbol
Cdc45provided by FlyBase
Official Full Name
Cell division cycle 45provided by FlyBase
Primary source
FLYBASE:FBgn0026143
Locus tag
Dmel_CG3658
See related
AllianceGenome:FB:FBgn0026143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-1Ec; cdc45; CDC45; CDC45L; CG3658; D; dCDC45; dCDC45L; DmCdc45; Dmel\CG3658; EG:BACR7A4.11
Summary
Enables chromatin binding activity. Involved in DNA amplification; DNA replication; and chromosome condensation. Located in cytoplasm and nucleus. Part of CMG complex. Is expressed in egg chamber. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 7. Orthologous to human CDC45 (cell division cycle 45). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Cdc45 in Genome Data Viewer
Location:
1E1-1E1; 1-0.1 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (1028291..1030556, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (922324..924589, complement)

Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene suppressor of white-apricot Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribonuclease P/MRP subunit p21 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High abundance of CDC45 inhibits cell proliferation through elevation of HSPA6. Fu Y, et al. Cell Prolif, 2022 Jul. PMID 35642733, Free PMC Article
  2. DNA copy-number control through inhibition of replication fork progression. Nordman JT, et al. Cell Rep, 2014 Nov 6. PMID 25437540, Free PMC Article
  3. humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Bandura JL, et al. Curr Biol, 2005 Apr 26. PMID 15854909
  4. Molecular cloning and genetic analysis of the suppressor-of-white-apricot locus from Drosophila melanogaster. Zachar Z, et al. Mol Cell Biol, 1987 Jul. PMID 3039348, Free PMC Article
  5. DNA replication machinery contributes to development of eye in Drosophila. Kohzaki H, et al. Front Biosci (Landmark Ed), 2018 Jan 1. PMID 28930558

See all (76) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show the structure of the Cdc45/Mcm2-7/Psf1 GINS (CMG) helicase in the presence of ATPgammaS and a DNA duplex bearing a 3' single-stranded tail.
    Title: DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA replication origin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables single-stranded DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in DNA amplification IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in DNA replication IPI
Inferred from Physical Interaction
more info
 PubMed 
involved_in DNA replication initiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA replication initiation IC
Inferred by Curator
more info
 PubMed 
involved_in DNA replication initiation IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication initiation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in chromosome condensation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in double-strand break repair via break-induced replication IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mitotic DNA replication preinitiation complex assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of CMG complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of DNA replication preinitiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of DNA replication preinitiation complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle 45
Names
CDC45L
CG3658-PA
Cdc45-PA
transcription unit D

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004354.4 Reference assembly

    Range
    1028291..1030556 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130524.5 → NP_569880.1  cell division cycle 45 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_569880.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O96989
    Related
    FBpp0070175
    Conserved Domains (1) summary
    pfam02724
    Location:19 → 570
    CDC45; CDC45-like protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
6RAW_A.1
6RAX_A.1
6RAY_A.1
6RAZ_A.1
O96989 O96989

Gene LinkOut

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