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P2ry13 purinergic receptor P2Y13 [ Rattus norvegicus (Norway rat) ]

Gene ID: 310444, updated on 5-Mar-2024

Summary

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Official Symbol
P2ry13provided by RGD
Official Full Name
purinergic receptor P2Y13provided by RGD
Primary source
RGD:1302941
See related
Ensembl:ENSRNOG00000029756 AllianceGenome:RGD:1302941
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
P2y13
Summary
Enables G protein-coupled purinergic nucleotide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within cellular response to organic cyclic compound. Predicted to be located in endoplasmic reticulum. Orthologous to human P2RY13 (purinergic receptor P2Y13). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 158.1), Thymus (RPKM 51.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q26
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (145620321..145624730, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (143470437..143476360, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (149429648..149432864, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene mediator complex subunit 12L Neighboring gene purinergic receptor P2Y14 Neighboring gene G protein-coupled receptor 87 Neighboring gene purinergic receptor P2Y12 Neighboring gene immunoglobulin superfamily, member 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia. Zeng J, et al. Neurochem Res, 2014 Nov. PMID 25186167
  2. P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells. Gao ZG, et al. Pharmacol Res, 2010 Dec. PMID 20813187, Free PMC Article
  3. Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor. Fumagalli M, et al. Biochem Pharmacol, 2004 Jul 1. PMID 15183123
  4. P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo. de Almeida-Pereira L, et al. Mol Neurobiol, 2018 Nov. PMID 29574630
  5. Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery. Morente V, et al. Biochim Biophys Acta, 2014 Sep. PMID 24851838

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. P2Y13 receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
    Title: P2Y(13) receptor involved in HIV-1 gp120 induced neuropathy in superior cervical ganglia through NLRP3 inflammasome activation.
  2. P2Y13 and P2X7 receptors modulate mechanically induced adenosine triphosphate release from mast cells.
    Title: P2Y(13) and P2X(7) receptors modulate mechanically induced adenosine triphosphate release from mast cells.
  3. Gene expression of the purinergic P2Y12 subtype was detected in rat retina during early postnatal days (P0 to P5), while expression levels of P2Y13 were low.
    Title: P2Y(12) but not P2Y(13) Purinergic Receptor Controls Postnatal Rat Retinogenesis In Vivo.
  4. the activation of P2Y13 receptor might be involved in the effect of ADP on [Ca(2+)]i in cultured dorsal spinal cord microglia
    Title: P2Y13 receptor-mediated rapid increase in intracellular calcium induced by ADP in cultured dorsal spinal cord microglia.
  5. P2Y13 receptors regulate DUSP2 expression and contribute to p38 signaling homeostasis and survival in granule neurons.
    Title: Neuroprotection elicited by P2Y13 receptors against genotoxic stress by inducing DUSP2 expression and MAPK signaling recovery.
  6. P2Y13 receptor in invloves in suppression of neuronal differentiation. P2Y13 receptor antagonists might be candidates for treatment of neurodegenerative diseases.
    Title: Involvement of P2Y13 receptor in suppression of neuronal differentiation.
  7. ADP-mediated intracellular calcium mobilization and Hex release in RBL-2H3 cells are via P2Y(1) and P2y13 receptors, respectively.
    Title: P2Y(13) receptor is responsible for ADP-mediated degranulation in RBL-2H3 rat mast cells.
  8. results show a previously unrecognized role of the purinergic P2Y13 receptor in the induction of the Nrf2/HO-1 antioxidant response and in protection against oxidative stress
    Title: The purinergic P2Y(13) receptor activates the Nrf2/HO-1 axis and protects against oxidative stress-induced neuronal death.
  9. rat P2rY13 receptor displays several similarities but also interesting differences with its human and mouse orthologs [P2Y(13)]
    Title: Cloning, pharmacological characterisation and distribution of the rat G-protein-coupled P2Y(13) receptor.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled purinergic nucleotide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled purinergic nucleotide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled purinergic nucleotide receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
P2Y purinoceptor 13
Names
purinergic receptor P2Y, G-protein coupled, 13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002853.1 → NP_001002853.1  P2Y purinoceptor 13

    See identical proteins and their annotated locations for NP_001002853.1

    Status: PROVISIONAL

    Source sequence(s)
    AY639875
    UniProtKB/Swiss-Prot
    Q6GUG4
    UniProtKB/TrEMBL
    A6JVK3
    Conserved Domains (2) summary
    cd14964
    Location:28 → 55
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:28 → 309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    145620321..145624730 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008760991.4 → XP_008759213.1  P2Y purinoceptor 13 isoform X1

    See identical proteins and their annotated locations for XP_008759213.1

    UniProtKB/Swiss-Prot
    Q6GUG4
    UniProtKB/TrEMBL
    A6JVK3
    Related
    ENSRNOP00000047532.1
    Conserved Domains (2) summary
    cd14964
    Location:28 → 55
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:28 → 309
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6GUG4.1 GenPept UniProtKB/Swiss-Prot:Q6GUG4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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