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Pde8b phosphodiesterase 8B [ Rattus norvegicus (Norway rat) ]

Gene ID: 309962, updated on 30-Mar-2024

Summary

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Official Symbol
Pde8bprovided by RGD
Official Full Name
phosphodiesterase 8Bprovided by RGD
Primary source
RGD:735041
See related
Ensembl:ENSRNOG00000010280 AllianceGenome:RGD:735041
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RNPDE8B
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 104.4), Brain (RPKM 87.7) and 6 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
2q12
Exon count:
24
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (28009841..28244050, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (26275117..26479725, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (24718548..24955533, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108350223 Neighboring gene WD repeat domain 41 Neighboring gene uncharacterized LOC134485577 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134485576 Neighboring gene uncharacterized LOC134485713 Neighboring gene uncharacterized LOC100912266 Neighboring gene succinate dehydrogenase complex subunit C, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Diminished phosphodiesterase-8B potentiates biphasic insulin response to glucose. Dov A, et al. Endocrinology, 2008 Feb. PMID 17991719
  2. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi T, et al. Gene, 2003 Nov 13. PMID 14597168
  3. Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3',5'-cyclic nucleotide phosphodiesterase. Hayashi M, et al. Biochem Biophys Res Commun, 1998 Sep 29. PMID 9784418
  4. The high-affinity cAMP-specific phosphodiesterase 8B controls steroidogenesis in the mouse adrenal gland. Tsai LC, et al. Mol Pharmacol, 2011 Apr. PMID 21187369, Free PMC Article
  5. Phosphodiesterase 3 and 4 comprise the major cAMP metabolizing enzymes responsible for insulin secretion in INS-1 (832/13) cells and rat islets. Waddleton D, et al. Biochem Pharmacol, 2008 Oct 1. PMID 18706893

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within behavioral fear response ISO
Inferred from Sequence Orthology
more info
  
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of insulin secretion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of steroid hormone biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neuromuscular process controlling balance ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within operant conditioning ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within visual learning ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B
Names
cAMP-specific cyclic nucleotide phosphodiesterase PDE8
NP_954889.1
XP_006231873.1
XP_008758892.1
XP_017446305.1
XP_017446306.1
XP_038958091.1
XP_038958092.1
XP_063137771.1
XP_063137772.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_199268.2 → NP_954889.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B

    See identical proteins and their annotated locations for NP_954889.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000002
    UniProtKB/TrEMBL
    F7ES56, Q76KC5
    Related
    ENSRNOP00000050643.3, ENSRNOT00000044087.4
    Conserved Domains (3) summary
    cd00130
    Location:160 → 252
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:490 → 737
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:155 → 253
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    28009841..28244050 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063281702.1 → XP_063137772.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X7

  2. XM_008760670.4 → XP_008758892.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTX5, A0A8I6GB63
    Related
    ENSRNOP00000082132.1
    Conserved Domains (4) summary
    cd00130
    Location:284 → 376
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:614 → 861
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:279 → 377
    PAS_9; PAS domain

  3. XM_063281701.1 → XP_063137771.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X4

  4. XM_017590817.3 → XP_017446306.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X3

    UniProtKB/TrEMBL
    A0A8I6AKA5

  5. XM_039102163.2 → XP_038958091.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X6

    UniProtKB/TrEMBL
    A0A8I6AKA5, A6I4Y1
    Conserved Domains (3) summary
    PHA02597
    Location:157 → 310
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:516 → 763
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase

  6. XM_006231811.5 → XP_006231873.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X5

    UniProtKB/TrEMBL
    A0A8I6AJW4, A0A8I6AKA5
    Related
    ENSRNOP00000093463.1
    Conserved Domains (3) summary
    PHA02597
    Location:158 → 311
    30.2; hypothetical protein; Provisional
    pfam00233
    Location:517 → 764
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 47
    PDE8; PDE8 phosphodiesterase

  7. XM_017590816.3 → XP_017446305.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X2

    UniProtKB/TrEMBL
    A0A8I6GB63
    Related
    ENSRNOP00000083813.1

  8. XM_039102164.2 → XP_038958092.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZT43
    Conserved Domains (3) summary
    COG2202
    Location:55 → 263
    PAS; PAS domain [Signal transduction mechanisms]
    pfam00233
    Location:502 → 749
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam13426
    Location:168 → 265
    PAS_9; PAS domain
Nucleotide Protein Strain
Heading Accession and Version

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