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Adat1 adenosine deaminase, tRNA-specific 1 [ Mus musculus (house mouse) ]

Gene ID: 30947, updated on 5-Mar-2024

Summary

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Official Symbol
Adat1provided by MGI
Official Full Name
adenosine deaminase, tRNA-specific 1provided by MGI
Primary source
MGI:MGI:1353631
See related
Ensembl:ENSMUSG00000031949 AllianceGenome:MGI:1353631
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
MMADAT1
Summary
Predicted to enable RNA binding activity and tRNA-specific adenosine deaminase activity. Predicted to be involved in tRNA processing. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human ADAT1 (adenosine deaminase tRNA specific 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E11.5 (RPKM 4.2), limb E14.5 (RPKM 2.9) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Adat1 in Genome Data Viewer
Location:
8 E1; 8 58.23 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (112685552..112718938, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (111958920..111992307, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene transmembrane protein 231 Neighboring gene predicted gene, 36531 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114464460-114464569 Neighboring gene STARR-seq mESC enhancer starr_22729 Neighboring gene GABA type A receptor associated protein like 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:114500469-114500652 Neighboring gene STARR-positive B cell enhancer ABC_E6687 Neighboring gene STARR-positive B cell enhancer ABC_E1376 Neighboring gene lysyl-tRNA synthetase 1 Neighboring gene telomeric repeat binding factor 2, interacting protein Neighboring gene heterogeneous nuclear ribonucleoprotein A3 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Sequence, genomic organization and functional expression of the murine tRNA-specific adenosine deaminase ADAT1. Maas S, et al. Gene, 2000 Feb 8. PMID 10675613
  2. Genomic clustering of tRNA-specific adenosine deaminase ADAT1 and two tRNA synthetases. Maas S, et al. Mamm Genome, 2001 May. PMID 11331948
  3. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding ISO
Inferred from Sequence Orthology
more info
  
enables adenosine deaminase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA-specific adenosine deaminase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA-specific adenosine deaminase activity ISO
Inferred from Sequence Orthology
more info
  
enables tRNA-specific adenosine deaminase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables tRNA-specific adenosine-37 deaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA processing ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  

General protein information

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Preferred Names
tRNA-specific adenosine deaminase 1
Names
tRNA-specific adenosine-37 deaminase
NP_001344113.1
NP_001344114.1
NP_001344115.1
NP_038953.1
XP_006531138.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357184.1 → NP_001344113.1  tRNA-specific adenosine deaminase 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AK035614, AK082399, AK161044
    UniProtKB/TrEMBL
    D3Z6J6
    Related
    ENSMUSP00000113201.2, ENSMUST00000120457.2
    Conserved Domains (1) summary
    pfam02137
    Location:63 → 371
    A_deamin; Adenosine-deaminase (editase) domain

  2. NM_001357185.1 → NP_001344114.1  tRNA-specific adenosine deaminase 1 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC114648, AK082399, AK161044
    Consensus CDS
    CCDS90464.1
    Related
    ENSMUSP00000117279.2, ENSMUST00000139820.8
    Conserved Domains (1) summary
    pfam02137
    Location:63 → 453
    A_deamin; Adenosine-deaminase (editase) domain

  3. NM_001357186.1 → NP_001344115.1  tRNA-specific adenosine deaminase 1 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC114648, AC115914
    UniProtKB/TrEMBL
    D3Z6J6
    Conserved Domains (1) summary
    pfam02137
    Location:63 → 402
    A_deamin; Adenosine-deaminase (editase) domain

  4. NM_013925.5 → NP_038953.1  tRNA-specific adenosine deaminase 1 isoform 1

    See identical proteins and their annotated locations for NP_038953.1

    Status: VALIDATED

    Source sequence(s)
    AC115914, AK082399
    Consensus CDS
    CCDS22684.1
    UniProtKB/Swiss-Prot
    Q3TU04, Q8CBP0, Q8VE23, Q9JHI2
    Related
    ENSMUSP00000034427.6, ENSMUST00000034427.12
    Conserved Domains (1) summary
    pfam02137
    Location:63 → 492
    A_deamin; Adenosine-deaminase (editase) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    112685552..112718938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006531075.5 → XP_006531138.1  tRNA-specific adenosine deaminase 1 isoform X1

    UniProtKB/TrEMBL
    D3Z6J6
    Conserved Domains (1) summary
    pfam02137
    Location:63 → 410
    A_deamin; Adenosine-deaminase (editase) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9JHI2.1 GenPept UniProtKB/Swiss-Prot:Q9JHI2

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