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Pip5k1b phosphatidylinositol-4-phosphate 5-kinase type 1 beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 309419, updated on 11-Apr-2024

Summary

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Official Symbol
Pip5k1bprovided by RGD
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase type 1 betaprovided by RGD
Primary source
RGD:1310914
See related
Ensembl:ENSRNOG00000015232 AllianceGenome:RGD:1310914
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Pip5k1a
Summary
Predicted to enable 1-phosphatidylinositol-4-phosphate 5-kinase activity. Predicted to be involved in phosphatidylinositol phosphate biosynthetic process and phosphorylation. Predicted to act upstream of or within phosphatidylinositol biosynthetic process. Predicted to be located in cytosol and uropod. Orthologous to human PIP5K1B (phosphatidylinositol-4-phosphate 5-kinase type 1 beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 84.3), Spleen (RPKM 62.4) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pip5k1b in Genome Data Viewer
Location:
1q51
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (231331836..231610092, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (221907220..222183672, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (242168462..242441247, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483979 Neighboring gene tight junction protein 2 Neighboring gene uncharacterized LOC120100005 Neighboring gene frataxin Neighboring gene uncharacterized LOC134483980 Neighboring gene dynein light chain Tctex-type 1, pseudogene1 Neighboring gene PP2A Aalpha (PPP2R1A) and B55A (PPP2R2A) interacting phosphatase regulator 1 Neighboring gene transmembrane protein 252 Neighboring gene phosphoglucomutase 5

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses. Lee SY, et al. Exp Mol Med, 2010 Sep 30. PMID 20720456, Free PMC Article
  2. Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells. Liu T, et al. Exp Mol Med, 2013 Mar 29. PMID 23538529, Free PMC Article
  3. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells. Vasudevan L, et al. J Cell Sci, 2009 Jul 15. PMID 19549683, Free PMC Article
  4. An isoform-specific PDZ-binding motif targets type I PIP5 kinase beta to the uropod and controls polarization of neutrophil-like HL60 cells. Mañes S, et al. FASEB J, 2010 Sep. PMID 20442317
  5. Cloning of cDNAs encoding two isoforms of 68-kDa type I phosphatidylinositol-4-phosphate 5-kinase. Ishihara H, et al. J Biol Chem, 1996 Sep 27. PMID 8798574

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PIP5Kalpha acts as a negative regulator of nerve growth factor-induced neurite outgrowth by inhibiting PI3K/Akt signaling pathway in PC12 cells.
    Title: Phosphatidylinositol 4-phosphate 5-kinase α negatively regulates nerve growth factor-induced neurite outgrowth in PC12 cells.
  2. Ganglioside treatment of primary astrocytes enhances PIP5Kalpha expression. PIP5Kalpha knockdown attenuates ganglioside-induced inflammatory responses.
    Title: Phosphatidylinositol 4-phosphate 5-kinase alpha is induced in ganglioside-stimulated brain astrocytes and contributes to inflammatory responses.
  3. The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
    Title: The beta- and gamma-isoforms of type I PIP5K regulate distinct stages of Ca2+ signaling in mast cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC105713

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphatidylinositol metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in endomembrane system IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in uropod IEA
Inferred from Electronic Annotation
more info
  
located_in uropod ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-phosphate 5-kinase type-1 beta
Names
PIP5K1-beta
PIP5KIalpha
PIP5KIbeta
phosphatidylinositol 4-phosphate 5-kinase type I alpha
phosphatidylinositol 4-phosphate 5-kinase type I beta
phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha
ptdIns(4)P-5-kinase 1 beta
ptdIns(4)P-5-kinase beta
NP_001012761.1
XP_038936135.1
XP_063120787.1
XP_063120790.1
XP_063120793.1
XP_063120797.1
XP_063120800.1
XP_063120802.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012743.1 → NP_001012761.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta

    See identical proteins and their annotated locations for NP_001012761.1

    Status: PROVISIONAL

    Source sequence(s)
    BC090349
    UniProtKB/Swiss-Prot
    Q5CZZ9
    UniProtKB/TrEMBL
    A0A096MK77
    Related
    ENSRNOP00000063506.2, ENSRNOT00000068645.5
    Conserved Domains (1) summary
    smart00330
    Location:53 → 393
    PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    231331836..231610092 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039080207.2 → XP_038936135.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X2

    UniProtKB/TrEMBL
    A0A096MK77
    Conserved Domains (1) summary
    cd17307
    Location:27 → 400
    PIPKc_PIP5K1B; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 beta (PIP5K1beta) and similar proteins

  2. XM_063264723.1 → XP_063120793.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X4

    UniProtKB/Swiss-Prot
    Q5CZZ9

  3. XM_063264717.1 → XP_063120787.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X1

  4. XM_063264730.1 → XP_063120800.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X6

  5. XM_063264727.1 → XP_063120797.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X5

  6. XM_063264720.1 → XP_063120790.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X3

  7. XM_063264732.1 → XP_063120802.1  phosphatidylinositol 4-phosphate 5-kinase type-1 beta isoform X7

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5CZZ9.1 GenPept UniProtKB/Swiss-Prot:Q5CZZ9

Gene LinkOut

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