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Ppp2r5b protein phosphatase 2, regulatory subunit B', beta [ Rattus norvegicus (Norway rat) ]

Gene ID: 309179, updated on 30-Mar-2024

Summary

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Official Symbol
Ppp2r5bprovided by RGD
Official Full Name
protein phosphatase 2, regulatory subunit B', betaprovided by RGD
Primary source
RGD:727786
See related
Ensembl:ENSRNOG00000021025 AllianceGenome:RGD:727786
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable protein phosphatase activator activity. Acts upstream of or within several processes, including positive regulation of cellular component organization; regulation of protein phosphorylation; and regulation of transcription, DNA-templated. Predicted to be part of protein phosphatase type 2A complex. Predicted to be active in cytosol and nucleus. Orthologous to human PPP2R5B (protein phosphatase 2 regulatory subunit B'beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 225.4), Kidney (RPKM 112.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q43
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (212956533..212964706, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (203527268..203535442, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (221597294..221605467, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene basic leucine zipper ATF-like transcription factor 2 Neighboring gene membrane anchored junction protein Neighboring gene glycoprotein hormone subunit alpha 2 Neighboring gene autophagy related 2A Neighboring gene microRNA 194-2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distinct protein phosphatase 2A heterotrimers modulate growth factor signaling to extracellular signal-regulated kinases and Akt. Van Kanegan MJ, et al. J Biol Chem, 2005 Oct 28. PMID 16129692
  2. The protein phosphatase 2A regulatory subunits B'beta and B'delta mediate sustained TrkA neurotrophin receptor autophosphorylation and neuronal differentiation. Van Kanegan MJ, et al. Mol Cell Biol, 2009 Feb. PMID 19029245, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein phosphatase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to growth factor stimulus IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within negative regulation of G0 to G1 transition IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of neurotrophin TRK receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of protein-containing complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within regulation of cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of peptidyl-tyrosine phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein autophosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein autophosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of protein phosphatase type 2A complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_181379.3 → NP_852044.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform

    See identical proteins and their annotated locations for NP_852044.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/Swiss-Prot
    Q80W83
    Related
    ENSRNOP00000028542.4, ENSRNOT00000028542.7
    Conserved Domains (1) summary
    pfam01603
    Location:69 → 467
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    212956533..212964706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039079691.2 → XP_038935619.1  serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform isoform X1

    Conserved Domains (1) summary
    pfam01603
    Location:69 → 260
    B56; Protein phosphatase 2A regulatory B subunit (B56 family)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q80W83.1 GenPept UniProtKB/Swiss-Prot:Q80W83

Gene LinkOut

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