Dock1 dedicator of cyto-kinesis 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Dock1provided by RGD
Full Name: dedicator of cyto-kinesis 1provided by RGD
Primary source: RGD:1566072
See related: Ensembl:ENSRNOG00000018683 AllianceGenome:RGD:1566072
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1566072
Summary: Predicted to contribute to guanyl-nucleotide exchange factor activity. Predicted to be involved in positive regulation of epithelial cell migration and positive regulation of substrate adhesion-dependent cell spreading. Predicted to act upstream of or within cell migration and hematopoietic progenitor cell differentiation. Predicted to be located in cytosol and nuclear speck. Predicted to be part of guanyl-nucleotide exchange factor complex. Orthologous to human DOCK1 (dedicator of cytokinesis 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly
Expression: Biased expression in Adrenal (RPKM 226.5), Kidney (RPKM 222.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q41

Exon count:: 52

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (198897021..199413636)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (189467143..189983777)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (206900617..207414852)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RHOG can mediate signaling through downstream effectors DOCK1 and RAC1 during ovarian follicular development (theca and granulosa cells and oocyte), but dehydroepiandrosterone downregulated them in the polycystic ovarian syndrome ovary.
Title: RHOG-DOCK1-RAC1 Signaling Axis Is Perturbed in DHEA-Induced Polycystic Ovary in Rat Model.
Dock180 protein is expressed in the myocardium in rats. Furthermore, its expression is significantly increased in the noninfarcted myocardium of the peri-infarct zones.
Title: Increased expression of Dock180 protein in the noninfarcted myocardium in rats.
Dock180 could act as a pro-survival molecule in H9C2 cardiomyocytes via activation of its downstream pro-survival signaling molecule, AKT.
Title: Pro-survival effect of Dock180 overexpression on rat-derived H9C2 cardiomyocytes.
The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.
Title: The RhoG/ELMO1/Dock180 signaling module is required for spine morphogenesis in hippocampal neurons.

Submit: New GeneRIF Correction

General gene information

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Markers

AU048482 (e-PCR)
- UniSTS:144932

BE112057 (e-PCR)
- UniSTS:246060

AI267063 (e-PCR)
- UniSTS:208220

AU048801 (e-PCR)
- UniSTS:145251

RH136909 (e-PCR)
- UniSTS:218998

RH127500 (e-PCR)
- UniSTS:210810

D1Rat439 (e-PCR), detects polymorphism
- UniSTS:227222

RH133979 (e-PCR)
- UniSTS:217261

RH139279 (e-PCR)
- UniSTS:221365

RH129098 (e-PCR)
- UniSTS:212406

BE121032 (e-PCR)
- UniSTS:248003

BF412660 (e-PCR)
- UniSTS:248271

RH140079 (e-PCR)
- UniSTS:222160

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables guanyl-nucleotide exchange factor activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to guanyl-nucleotide exchange factor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in myoblast fusion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of substrate adhesion-dependent cell spreading	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
part_of guanyl-nucleotide exchange factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: dedicator of cytokinesis protein 1

Names: dedicator of cytokinesis protein 1-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001143858.1 → NP_001137330.1 dedicator of cytokinesis protein 1

Status: PROVISIONAL

Source sequence(s)

AABR07005930, AABR07005931, AABR07005934, AABR07005936, AABR07005937

UniProtKB/TrEMBL

A6HX51

Related

ENSRNOT00000054897.3

Conserved Domains (4) summary

cd08694
Location:424 → 619

C2_Dock-A; C2 domains found in Dedicator Of CytoKinesis (Dock) class A proteins

cd12051
Location:13 → 68

SH3_DOCK1_5_A; Src Homology 3 domain of Class A Dedicator of Cytokinesis proteins 1 and 5

pfam16172
Location:72 → 416

DOCK_N; DOCK N-terminus

cl06123
Location:1214 → 1612

DHR2_DOCK; Dock Homology Region 2, a GEF domain, of Dedicator of Cytokinesis proteins