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Uros uroporphyrinogen III synthase [ Rattus norvegicus (Norway rat) ]

Gene ID: 309070, updated on 3-Apr-2024

Summary

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Official Symbol
Urosprovided by RGD
Official Full Name
uroporphyrinogen III synthaseprovided by RGD
Primary source
RGD:1310396
See related
Ensembl:ENSRNOG00000017810 AllianceGenome:RGD:1310396
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables folic acid binding activity. Contributes to uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to amine stimulus; response to platinum ion; and uroporphyrinogen III biosynthetic process. Located in cytosol. Used to study cutaneous porphyria. Human ortholog(s) of this gene implicated in cutaneous porphyria. Orthologous to human UROS (uroporphyrinogen III synthase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Spleen (RPKM 79.8), Muscle (RPKM 45.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Uros in Genome Data Viewer
Location:
1q41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (197920827..197943183, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (188490832..188513659, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (205755766..205778170, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene erythroid differentiation regulatory factor 1 Neighboring gene matrix metallopeptidase 21 Neighboring gene BRCA2 and CDKN1A interacting protein Neighboring gene DEAH-box helicase 32 (putative) Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene peptidyl-prolyl cis-trans isomerase A-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Characterization of his-tagged rat uroporphyrinogen III synthase wild-type and variant enzymes. Li N, et al. Protein J, 2007 Dec. PMID 17763925
  2. Irgasan DP 300 (5-chloro-2-(2,4-dichlorophenoxy)-phenol) induces cytochrome P450s and inhibits haem biosynthesis in rat hepatocytes cultured on Matrigel. Jinno H, et al. Xenobiotica, 1997 Jul. PMID 9253145
  3. Biosynthesis of uroporphyrinogens. Interaction among 2-(aminomethyl)bilanes and the enzymatic system. Sburlati A, et al. Biochemistry, 1983 Aug 16. PMID 6604545
  4. Alterations in renal heme biosynthesis during metal nephrotoxicity. Oskarsson A, et al. Ann N Y Acad Sci, 1987. PMID 3327431
  5. Rat hepatic uroporphyrinogen III co-synthase. Purification and evidence for a bound folate coenzyme participating in the biosynthesis of uroporphyrinogen III. Kohashi M, et al. Biochem J, 1984 Jun 15. PMID 6466301, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables folic acid binding IDA
Inferred from Direct Assay
more info
 PubMed 
contributes_to uroporphyrinogen-III synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables uroporphyrinogen-III synthase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cellular response to amine stimulus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in cellular response to arsenic-containing substance IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in heme A biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme B biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme O biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in heme biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within porphyrin-containing compound biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protoporphyrinogen IX biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to platinum ion IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in uroporphyrinogen III biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in uroporphyrinogen III biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in uroporphyrinogen III biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
uroporphyrinogen-III synthase
Names
urogen III synthase
uroporphyrinogen III co-synthase
NP_001012068.1
XP_008758113.1
XP_017444718.1
XP_063119843.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001012068.1 → NP_001012068.1  uroporphyrinogen-III synthase

    See identical proteins and their annotated locations for NP_001012068.1

    Status: PROVISIONAL

    Source sequence(s)
    BC083730
    UniProtKB/TrEMBL
    F7ET42, Q5XIF2
    Related
    ENSRNOP00000024278.3, ENSRNOT00000024279.5
    Conserved Domains (1) summary
    cd06578
    Location:3 → 255
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    197920827..197943183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063263773.1 → XP_063119843.1  uroporphyrinogen-III synthase isoform X2

    UniProtKB/TrEMBL
    F7ET42, Q5XIF2

  2. XM_017589229.3 → XP_017444718.1  uroporphyrinogen-III synthase isoform X1

    Conserved Domains (1) summary
    cd06578
    Location:3 → 263
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...

  3. XM_008759891.3 → XP_008758113.1  uroporphyrinogen-III synthase isoform X1

    See identical proteins and their annotated locations for XP_008758113.1

    Conserved Domains (1) summary
    cd06578
    Location:3 → 263
    HemD; Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in ...
Nucleotide Protein Strain
Heading Accession and Version

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