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Pde8a phosphodiesterase 8A [ Rattus norvegicus (Norway rat) ]

Gene ID: 308776, updated on 5-Mar-2024

Summary

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Official Symbol
Pde8aprovided by RGD
Official Full Name
phosphodiesterase 8Aprovided by RGD
Primary source
RGD:735125
See related
Ensembl:ENSRNOG00000019005 AllianceGenome:RGD:735125
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
RNPDE8A
Summary
Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity; 3',5'-cyclic-GMP phosphodiesterase activity; and kinase binding activity. Predicted to be involved in several processes, including cellular response to epidermal growth factor stimulus; negative regulation of hydrogen peroxide-induced cell death; and positive regulation of ERK1 and ERK2 cascade. Orthologous to human PDE8A (phosphodiesterase 8A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Adrenal (RPKM 166.4), Kidney (RPKM 127.3) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q31
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (144575203..144698216)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (135166143..135288986)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (143036083..143160395)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene alpha-kinase 3 Neighboring gene solute carrier family 28 member 1 Neighboring gene small nucleolar RNA SNORA44 Neighboring gene ribosomal protein S17 Neighboring gene cytoplasmic polyadenylation element binding protein 1 Neighboring gene small nuclear ribonucleoprotein U11/U12 subunit 48, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Distribution of PDE8A in the nervous system of the Sprague-Dawley rat. Kruse LS, et al. J Chem Neuroanat, 2011 Nov. PMID 21821118
  2. Molecular comparison of rat cyclic nucleotide phosphodiesterase 8 family: unique expression of PDE8B in rat brain. Kobayashi T, et al. Gene, 2003 Nov 13. PMID 14597168
  3. Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. Soderling SH, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671792, Free PMC Article
  4. Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase. Fisher DA, et al. Biochem Biophys Res Commun, 1998 May 29. PMID 9618252
  5. Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Brown KM, et al. Proc Natl Acad Sci U S A, 2013 Apr 16. PMID 23509299, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-AMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 3',5'-cyclic-GMP phosphodiesterase activity ISO
Inferred from Sequence Orthology
more info
  
enables kinase binding ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in cAMP catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cAMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epidermal growth factor stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to epidermal growth factor stimulus ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in perinuclear region of cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Names
cAMP-specific cyclic nucleotide phosphodiesterase PDE8
NP_942062.1
XP_006229500.1
XP_038968970.2
XP_038968971.2
XP_038968972.2
XP_038968973.1
XP_063118773.1
XP_063118774.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_198767.1 → NP_942062.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A

    See identical proteins and their annotated locations for NP_942062.1

    Status: PROVISIONAL

    Source sequence(s)
    AB092696
    UniProtKB/TrEMBL
    A6JCF1, Q76KC6
    Related
    ENSRNOP00000025797.3, ENSRNOT00000025797.4
    Conserved Domains (4) summary
    cd00130
    Location:224 → 318
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:548 → 801
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 44
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:220 → 318
    PAS_9; PAS domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    144575203..144698216
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063262703.1 → XP_063118773.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X1

  2. XM_006229438.5 → XP_006229500.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X2

    See identical proteins and their annotated locations for XP_006229500.1

    UniProtKB/TrEMBL
    A6JCF1, Q76KC6
    Conserved Domains (4) summary
    cd00130
    Location:224 → 318
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
    pfam00233
    Location:548 → 801
    PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase
    pfam08629
    Location:1 → 44
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:220 → 318
    PAS_9; PAS domain

  3. XM_063262704.1 → XP_063118774.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X4

  4. XM_039113045.2 → XP_038968973.1  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X6

    Conserved Domains (3) summary
    COG2202
    Location:118 → 318
    PAS; PAS domain [Signal transduction mechanisms]
    pfam08629
    Location:1 → 24
    PDE8; PDE8 phosphodiesterase
    pfam13426
    Location:220 → 318
    PAS_9; PAS domain

  5. XM_039113042.2 → XP_038968970.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

  6. XM_039113043.2 → XP_038968971.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X3

  7. XM_039113044.2 → XP_038968972.2  high affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A isoform X5

Nucleotide Protein Strain
Heading Accession and Version

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