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Gpr4 G protein-coupled receptor 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308408, updated on 11-Apr-2024

Summary

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Official Symbol
Gpr4provided by RGD
Official Full Name
G protein-coupled receptor 4provided by RGD
Primary source
RGD:1311604
See related
Ensembl:ENSRNOG00000016362 AllianceGenome:RGD:1311604
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in several processes, including G protein-coupled receptor signaling pathway; positive regulation of Rho protein signal transduction; and response to acidic pH. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; blood vessel development; and negative regulation of angiogenesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. Orthologous to human GPR4 (G protein-coupled receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Heart (RPKM 15.7), Lung (RPKM 12.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q21
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (87993398..88004568)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (78865376..78877126)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (80125639..80136786)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene gastric inhibitory polypeptide receptor Neighboring gene EMAP like 2 Neighboring gene microRNA 330 Neighboring gene outer mitochondrial membrane lipid metabolism regulator OPA3 Neighboring gene vasodilator-stimulated phosphoprotein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment. Li H, et al. Biomed Res Int, 2020. PMID 32566653, Free PMC Article
  2. Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells. Musha S, et al. J Reprod Dev, 2020 Apr 10. PMID 31956173, Free PMC Article
  3. Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways. Liu JP, et al. Pharmacol Res, 2010 Jun. PMID 20211729
  4. Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms. Tobo M, et al. Cell Signal, 2007 Aug. PMID 17462861
  5. Vascular abnormalities in mice deficient for the G protein-coupled receptor GPR4 that functions as a pH sensor. Yang LV, et al. Mol Cell Biol, 2007 Feb. PMID 17145776, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
    Title: Involvement of the G-Protein-Coupled Receptor 4 in the Increased Expression of RANK/RANKL/OPG System and Neurotrophins by Nucleus Pulposus Cells under the Degenerated Intervertebral Disc-Like Acidic Microenvironment.
  2. Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
    Title: Involvement of GPR4 in increased growth hormone and prolactin expressions by extracellular acidification in MtT/S cells.
  3. Results indicate that GPR4 is expressed by multiple neuronal populations and endothelium and that its pH sensitivity is affected by level of expression and l-lactic acid (LL). GPR4 antagonist NE 52-QQ57 blunts hypercapnic response to CO2 but this effect is absent under anaesthesia, possibly due to the inhibitory effect of LL on GPR4.
    Title: CNS distribution, signalling properties and central effects of G-protein coupled receptor 4.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC116369

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
  
enables G protein-coupled receptor activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within angiogenesis involved in wound healing ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within glomerular mesangial cell development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of Rho protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of Rho protein signal transduction ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of cell adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of vascular permeability ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vascular permeability ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to acidic pH ISO
Inferred from Sequence Orthology
more info
  
involved_in response to acidic pH ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
G-protein coupled receptor 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001025680.1 → NP_001020851.1  G-protein coupled receptor 4

    See identical proteins and their annotated locations for NP_001020851.1

    Status: PROVISIONAL

    Source sequence(s)
    BC099196
    UniProtKB/Swiss-Prot
    Q4KLH9
    UniProtKB/TrEMBL
    A6J8L2
    Conserved Domains (1) summary
    cd15366
    Location:20 → 299
    7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    87993398..88004568
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006228418.3 → XP_006228480.1  G-protein coupled receptor 4 isoform X1

    See identical proteins and their annotated locations for XP_006228480.1

    UniProtKB/Swiss-Prot
    Q4KLH9
    UniProtKB/TrEMBL
    A6J8L2
    Related
    ENSRNOP00000021894.4
    Conserved Domains (1) summary
    cd15366
    Location:20 → 299
    7tmA_GPR4; proton-sensing G protein-coupled receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4KLH9.1 GenPept UniProtKB/Swiss-Prot:Q4KLH9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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