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Map3k4 mitogen activated protein kinase kinase kinase 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 308106, updated on 13-Apr-2024

Summary

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Official Symbol
Map3k4provided by RGD
Official Full Name
mitogen activated protein kinase kinase kinase 4provided by RGD
Primary source
RGD:1311192
See related
Ensembl:ENSRNOG00000017419 AllianceGenome:RGD:1311192
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable MAP kinase kinase kinase activity. Predicted to be involved in several processes, including positive regulation of DNA metabolic process; positive regulation of p38MAPK cascade; and response to UV-C. Predicted to act upstream of or within several processes, including chorionic trophoblast cell differentiation; male germ-line sex determination; and positive regulation of JUN kinase activity. Predicted to be located in cytoplasm. Orthologous to human MAP3K4 (mitogen-activated protein kinase kinase kinase 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 104.1), Heart (RPKM 86.7) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q11
Exon count:
30
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (50977870..51067117)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (48431801..48519358)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (48625714..48711642)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene deoxyuridine triphosphatase pseudogene Neighboring gene uncharacterized LOC120099124 Neighboring gene small nucleolar RNA SNORA17 Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC108349099 Neighboring gene uncharacterized LOC134482716

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models. Huang L, et al. J Cell Physiol, 2020 Apr. PMID 31602666
  2. Sex reversal in XY mice caused by dominant mutation on chromosome 17. Washburn LL, et al. Nature, 1983 May 26. PMID 6855886
  3. The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages. Liu H, et al. Free Radic Res, 2006 Aug. PMID 17015265, Free PMC Article
  4. A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways. Takekawa M, et al. EMBO J, 1997 Aug 15. PMID 9305639, Free PMC Article
  5. A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1/MEKK4 MAPKKK. Takekawa M, et al. Cell, 1998 Nov 13. PMID 9827804

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models.
    Title: Upregulation of miR-183 represses neuropathic pain through inhibiton of MAP3K4 in CCI rat models.
  2. ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages
    Title: The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase kinase kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within chorionic trophoblast cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in intracellular signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within male germ-line sex determination ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within placenta development ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of p38MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere capping ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of telomere maintenance via telomerase ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in response to UV-C ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase kinase kinase 4
NP_001100926.1
NP_001388382.1
NP_001402774.1
XP_038966489.1
XP_038966502.1
XP_063144502.1
XP_063144507.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107456.3 → NP_001100926.1  mitogen-activated protein kinase kinase kinase 4 isoform 2

    See identical proteins and their annotated locations for NP_001100926.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I5ZTM8, A6KJY7, D3ZGU6
    Related
    ENSRNOP00000062453.1, ENSRNOT00000064018.4
    Conserved Domains (2) summary
    smart00220
    Location:1122 → 1380
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd06626
    Location:1121 → 1380
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  2. NM_001401453.2 → NP_001388382.1  mitogen-activated protein kinase kinase kinase 4 isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A0G2K3R1
    Related
    ENSRNOP00000072741.1, ENSRNOT00000084317.2

  3. NM_001415845.1 → NP_001402774.1  mitogen-activated protein kinase kinase kinase 4 isoform 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GLL3
    Related
    ENSRNOP00000096435.1, ENSRNOT00000116657.1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    50977870..51067117
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063288432.1 → XP_063144502.1  mitogen-activated protein kinase kinase kinase 4 isoform X3

  2. XM_039110574.2 → XP_038966502.1  mitogen-activated protein kinase kinase kinase 4 isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZUS1
    Conserved Domains (1) summary
    cd06626
    Location:1252 → 1511
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  3. XM_039110561.2 → XP_038966489.1  mitogen-activated protein kinase kinase kinase 4 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZTM8
    Related
    ENSRNOP00000081978.1
    Conserved Domains (1) summary
    cd06626
    Location:1323 → 1582
    STKc_MEKK4; Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4

  4. XM_063288437.1 → XP_063144507.1  mitogen-activated protein kinase kinase kinase 4 isoform X4

Nucleotide Protein Strain
Heading Accession and Version

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