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Slc7a6 solute carrier family 7 member 6 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307811, updated on 11-Apr-2024

Summary

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Official Symbol
Slc7a6provided by RGD
Official Full Name
solute carrier family 7 member 6provided by RGD
Primary source
RGD:1309193
See related
Ensembl:ENSRNOG00000019943 AllianceGenome:RGD:1309193
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Y+LAT2; y+LAT-2
Summary
Predicted to enable L-amino acid transmembrane transporter activity and basic amino acid transmembrane transporter activity. Predicted to be involved in basic amino acid transmembrane transport and ornithine transport. Predicted to be located in intracellular membrane-bounded organelle and plasma membrane. Orthologous to human SLC7A6 (solute carrier family 7 member 6). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 121.3), Thymus (RPKM 98.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19q12
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (50982459..51010140)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (34073472..34100268)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (38152225..38179149)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene nuclear factor of activated T-cells 3 Neighboring gene epithelial splicing regulatory protein 2 Neighboring gene phospholipase A2, group XV Neighboring gene solute carrier family 7, member 6 opposite strand Neighboring gene protein arginine methyltransferase 7

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Upregulation of the heteromeric y⁺LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes. Zielińska M, et al. Neurochem Int, 2012 Sep. PMID 22401943
  2. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter. Zielińska M, et al. J Neurochem, 2015 Dec. PMID 26448619
  3. Ornithine transport via cationic amino acid transporter-1 is involved in ornithine cytotoxicity in retinal pigment epithelial cells. Kaneko S, et al. Invest Ophthalmol Vis Sci, 2007 Jan. PMID 17197568
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables L-amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables L-arginine transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine:L-arginine antiporter activity IEA
Inferred from Electronic Annotation
more info
  
enables L-lysine:L-arginine antiporter activity ISO
Inferred from Sequence Orthology
more info
  
enables L-lysine:L-arginine antiporter activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables arginine binding IEA
Inferred from Electronic Annotation
more info
  
enables arginine binding ISO
Inferred from Sequence Orthology
more info
  
enables basic amino acid transmembrane transporter activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in L-arginine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-arginine transmembrane transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in L-arginine transmembrane transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-leucine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in L-leucine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in L-lysine transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in amino acid transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine betaine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in glycine betaine transport ISO
Inferred from Sequence Orthology
more info
  
involved_in neutral amino acid transport ISO
Inferred from Sequence Orthology
more info
  
involved_in nitric oxide biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ornithine transport IEA
Inferred from Electronic Annotation
more info
  
involved_in ornithine transport ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Y+L amino acid transporter 2
Names
solute carrier family 7 (amino acid transporter light chain, y+L system), member 6
solute carrier family 7 (cationic amino acid transporter, y+ system), member 6
y(+)L-type amino acid transporter 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001107424.1 → NP_001100894.1  Y+L amino acid transporter 2

    See identical proteins and their annotated locations for NP_001100894.1

    Status: PROVISIONAL

    Source sequence(s)
    CH473972
    UniProtKB/Swiss-Prot
    D3ZMM8
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    50982459..51010140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008772500.4 → XP_008770722.1  Y+L amino acid transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_008770722.1

    UniProtKB/Swiss-Prot
    D3ZMM8
    Related
    ENSRNOP00000027117.3
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  2. XM_008772501.4 → XP_008770723.1  Y+L amino acid transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_008770723.1

    UniProtKB/Swiss-Prot
    D3ZMM8
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  3. XM_039097744.2 → XP_038953672.1  Y+L amino acid transporter 2 isoform X3

    UniProtKB/Swiss-Prot
    D3ZMM8
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  4. XM_039097745.2 → XP_038953673.1  Y+L amino acid transporter 2 isoform X4

    Conserved Domains (1) summary
    TIGR00911
    Location:128 → 453
    2A0308; L-type amino acid transporter

  5. XM_039097743.2 → XP_038953671.1  Y+L amino acid transporter 2 isoform X2

    Conserved Domains (1) summary
    TIGR00911
    Location:127 → 511
    2A0308; L-type amino acid transporter

  6. XM_008772502.3 → XP_008770724.1  Y+L amino acid transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_008770724.1

    UniProtKB/Swiss-Prot
    D3ZMM8
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  7. XM_063278036.1 → XP_063134106.1  Y+L amino acid transporter 2 isoform X6

  8. XM_063278038.1 → XP_063134108.1  Y+L amino acid transporter 2 isoform X6

  9. XM_063278037.1 → XP_063134107.1  Y+L amino acid transporter 2 isoform X6

  10. XM_006255500.5 → XP_006255562.1  Y+L amino acid transporter 2 isoform X3

    See identical proteins and their annotated locations for XP_006255562.1

    UniProtKB/Swiss-Prot
    D3ZMM8
    Conserved Domains (1) summary
    TIGR00911
    Location:17 → 501
    2A0308; L-type amino acid transporter

  11. XM_006255498.5 → XP_006255560.1  Y+L amino acid transporter 2 isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZKR1
    Related
    ENSRNOP00000078355.1
    Conserved Domains (1) summary
    TIGR00911
    Location:30 → 514
    2A0308; L-type amino acid transporter

  12. XM_039097746.2 → XP_038953674.2  Y+L amino acid transporter 2 isoform X5

  13. XM_063278041.1 → XP_063134111.1  Y+L amino acid transporter 2 isoform X8

  14. XM_063278040.1 → XP_063134110.1  Y+L amino acid transporter 2 isoform X8

  15. XM_063278039.1 → XP_063134109.1  Y+L amino acid transporter 2 isoform X7

RNA

  1. XR_010060001.1 RNA Sequence

  2. XR_010059998.1 RNA Sequence

  3. XR_010059999.1 RNA Sequence

  4. XR_597221.4 RNA Sequence

  5. XR_010060002.1 RNA Sequence

  6. XR_010060000.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
D3ZMM8.1 GenPept UniProtKB/Swiss-Prot:D3ZMM8

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