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Lama3 laminin subunit alpha 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 307582, updated on 30-Mar-2024

Summary

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Official Symbol
Lama3provided by RGD
Official Full Name
laminin subunit alpha 3provided by RGD
Primary source
RGD:628776
See related
Ensembl:ENSRNOG00000011300 AllianceGenome:RGD:628776
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable signaling receptor binding activity. Involved in cell-cell adhesion and hemidesmosome assembly. Located in adherens junction and hemidesmosome. Part of laminin-3 complex. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa; junctional epidermolysis bullosa Herlitz type; junctional epidermolysis bullosa non-Herlitz type; and lung small cell carcinoma. Orthologous to human LAMA3 (laminin subunit alpha 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 161.0), Thymus (RPKM 49.3) and 7 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
18p13
Exon count:
80
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 18 NC_086036.1 (3797898..4033021)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 18 NC_051353.1 (3523168..3751722)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 18 NC_005117.4 (3704866..3941215)

Chromosome 18 - NC_086036.1Genomic Context describing neighboring genes Neighboring gene NPC intracellular cholesterol transporter 1 Neighboring gene AKT interacting protein, pseudogene 1 Neighboring gene ankyrin repeat domain 29 Neighboring gene uncharacterized LOC134482906 Neighboring gene uncharacterized LOC120098332 Neighboring gene uncharacterized LOC120098331 Neighboring gene ATP synthase subunit g, mitochondrial-like Neighboring gene U2 spliceosomal RNA Neighboring gene uncharacterized LOC134482905 Neighboring gene uncharacterized LOC134482904 Neighboring gene tetratricopeptide repeat domain 39C

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Laminin-5 and hemidesmosomes: role of the alpha 3 chain subunit in hemidesmosome stability and assembly. Baker SE, et al. J Cell Sci, 1996 Oct. PMID 8923212
  2. Cloning of the laminin alpha 3 chain gene (LAMA3) and identification of a homozygous deletion in a patient with Herlitz junctional epidermolysis bullosa. Vidal F, et al. Genomics, 1995 Nov 20. PMID 8586427
  3. Epigenetic inactivation of laminin-5-encoding genes in lung cancers. Sathyanarayana UG, et al. Clin Cancer Res, 2003 Jul. PMID 12855645
  4. Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain. Yamashita H, et al. J Cell Physiol, 2010 Jun. PMID 20301201, Free PMC Article
  5. Laminin-332-beta1 integrin interactions negatively regulate invadopodia. Liu S, et al. J Cell Physiol, 2010 Apr. PMID 20039268, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Binding sites for alpha3beta1 and alpha6beta4 are closely spaced in the Ln-332 LG domains where they regulate alternative cell functions, namely adhesion/migration or hemidesmosome anchoring.
    Title: Epitope mapping of function-blocking monoclonal antibody CM6 suggests a "weak" integrin binding site on the laminin-332 LG2 domain.
  2. In bladder carcinoma laminin-332 can suppress the number of invadopodia that form by interacting with a3b1 integrin and altering the cellular balance of FAK and Src kinase activity.
    Title: Laminin-332-beta1 integrin interactions negatively regulate invadopodia.
  3. a complex of laminin alpha 3, beta3 and gamma3 chains serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes
    Title: Laminin alpha 3 forms a complex with beta3 and gamma3 chains that serves as the ligand for alpha 6beta1-integrin at the apical ectoplasmic specialization in adult rat testes.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables signaling receptor binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell-cell adhesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endodermal cell differentiation ISO
Inferred from Sequence Orthology
more info
  
involved_in hemidesmosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of cell migration IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of embryonic development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
 PubMed 
located_in basement membrane ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in hemidesmosome IDA
Inferred from Direct Assay
more info
 PubMed 
part_of laminin-3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of laminin-5 complex ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
laminin subunit alpha-3
Names
laminin 5 alpha 3
laminin, alpha 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001393748.1 → NP_001380677.1  laminin subunit alpha-3 isoform B precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (B).
    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A0A1B0GWM3
    Related
    ENSRNOP00000075948.2, ENSRNOT00000092846.2
    Conserved Domains (9) summary
    smart00136
    Location:42 → 293
    LamNT; Laminin N-terminal domain (domain VI)
    smart00282
    Location:2434 → 2569
    LamG; Laminin G domain
    cd00055
    Location:531 → 573
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:3158 → 3309
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:2031 → 2387
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:1846 → 2103
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2287 → 2415
    Laminin_II; Laminin Domain II
    pfam00052
    Location:1517 → 1651
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1265 → 1313
    Laminin_EGF; Laminin EGF domain

  2. NM_173306.2 → NP_775428.2  laminin subunit alpha-3 isoform A precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000018
    UniProtKB/TrEMBL
    A6KLR5, D3ZN05, P70570
    Related
    ENSRNOP00000015363.8, ENSRNOT00000015363.8
    Conserved Domains (7) summary
    smart00282
    Location:826 → 961
    LamG; Laminin G domain
    cd00055
    Location:77 → 123
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1550 → 1701
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:423 → 779
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:238 → 495
    Laminin_I; Laminin Domain I
    pfam06009
    Location:679 → 807
    Laminin_II; Laminin Domain II
    NF033759
    Location:18 → 216
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086036.1 Reference GRCr8

    Range
    3797898..4033021
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039096924.2 → XP_038952852.1  laminin subunit alpha-3 isoform X1

    Conserved Domains (9) summary
    smart00282
    Location:2235 → 2370
    LamG; Laminin G domain
    cd00055
    Location:332 → 374
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:2959 → 3110
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:1832 → 2188
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:1647 → 1904
    Laminin_I; Laminin Domain I
    pfam06009
    Location:2088 → 2216
    Laminin_II; Laminin Domain II
    pfam00052
    Location:1318 → 1452
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:1066 → 1114
    Laminin_EGF; Laminin EGF domain
    cl02806
    Location:6 → 94
    Laminin_N; Laminin N-terminal (Domain VI)

  2. XM_039096925.2 → XP_038952853.1  laminin subunit alpha-3 isoform X2

    Conserved Domains (8) summary
    smart00282
    Location:1959 → 2094
    LamG; Laminin G domain
    cd00055
    Location:56 → 98
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:2683 → 2834
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:1556 → 1912
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:1371 → 1628
    Laminin_I; Laminin Domain I
    pfam06009
    Location:1812 → 1940
    Laminin_II; Laminin Domain II
    pfam00052
    Location:1042 → 1176
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:790 → 838
    Laminin_EGF; Laminin EGF domain

  3. XM_039096926.2 → XP_038952854.1  laminin subunit alpha-3 isoform X3

    UniProtKB/TrEMBL
    A6KLR4
    Conserved Domains (8) summary
    smart00282
    Location:1510 → 1645
    LamG; Laminin G domain
    cd00055
    Location:479 → 529
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:2234 → 2385
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:1107 → 1463
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:922 → 1179
    Laminin_I; Laminin Domain I
    pfam06009
    Location:1363 → 1491
    Laminin_II; Laminin Domain II
    pfam00052
    Location:593 → 727
    Laminin_B; Laminin B (Domain IV)
    pfam00053
    Location:341 → 389
    Laminin_EGF; Laminin EGF domain

  4. XM_039096927.2 → XP_038952855.1  laminin subunit alpha-3 isoform X4

    UniProtKB/TrEMBL
    A6KLR4
    Conserved Domains (8) summary
    smart00180
    Location:230 → 251
    EGF_Lam; Laminin-type epidermal growth factor-like domai
    smart00282
    Location:1011 → 1146
    LamG; Laminin G domain
    cd00055
    Location:262 → 308
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    cd00110
    Location:1735 → 1886
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    TIGR02168
    Location:608 → 964
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam06008
    Location:423 → 680
    Laminin_I; Laminin Domain I
    pfam06009
    Location:864 → 992
    Laminin_II; Laminin Domain II
    pfam00052
    Location:94 → 228
    Laminin_B; Laminin B (Domain IV)

RNA

  1. XR_005496046.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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