Etf1 eukaryotic translation termination factor 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Etf1provided by RGD
Official Full Name: eukaryotic translation termination factor 1provided by RGD
Primary source: RGD:1305712
See related: Ensembl:ENSRNOG00000019450 AllianceGenome:RGD:1305712
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable sequence-specific mRNA binding activity and translation release factor activity, codon specific. Predicted to be involved in cytoplasmic translational termination and regulation of translational termination. Predicted to act upstream of or within protein methylation and translational termination. Predicted to be located in cytoplasm. Predicted to be part of translation release factor complex. Orthologous to human ETF1 (eukaryotic translation termination factor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 357.6), Muscle (RPKM 357.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 18p12

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (26776518..26804857, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (26502413..26530753, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (27698693..27725694, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D6Ertd109e (e-PCR), detects polymorphism
- UniSTS:167468

RH130784 (e-PCR)
- UniSTS:214068

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables aminoacyl-tRNA hydrolase activity	ISO Inferred from Sequence Orthology more info
enables sequence-specific mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific mRNA binding	ISO Inferred from Sequence Orthology more info
enables translation release factor activity	ISO Inferred from Sequence Orthology more info
enables translation release factor activity, codon specific	IBA Inferred from Biological aspect of Ancestor more info
enables translation termination factor activity	ISO Inferred from Sequence Orthology more info
enables translation termination factor activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cytoplasmic translational termination	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA catabolic process, nonsense-mediated decay	IEA Inferred from Electronic Annotation more info
involved_in regulation of translational termination	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translational termination	ISO Inferred from Sequence Orthology more info
involved_in translational termination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
NOT located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of translation release factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of translation release factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: eukaryotic peptide chain release factor subunit 1

Names: eRF1; eukaryotic release factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008344.1 → NP_001008345.1 eukaryotic peptide chain release factor subunit 1

See identical proteins and their annotated locations for NP_001008345.1

Status: PROVISIONAL

Source sequence(s)

BC085902

UniProtKB/Swiss-Prot

Q5U2Q7

Related

ENSRNOP00000026398.4, ENSRNOT00000026398.6

Conserved Domains (1) summary

COG1503
Location:11 → 419

eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086036.1 Reference GRCr8

Range

26776518..26804857 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096867.2 → XP_038952795.1 eukaryotic peptide chain release factor subunit 1 isoform X1

UniProtKB/TrEMBL

A6J2W8

Conserved Domains (1) summary

COG1503
Location:1 → 386

eRF1; Peptide chain release factor 1 (eRF1) [Translation, ribosomal structure and biogenesis]