Tfap2a transcription factor AP-2 alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tfap2aprovided by RGD
Official Full Name: transcription factor AP-2 alphaprovided by RGD
Primary source: RGD:1310267
See related: Ensembl:ENSRNOG00000015522 AllianceGenome:RGD:1310267
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Tcfap2a
Summary: Enables sequence-specific DNA binding activity. Involved in several processes, including Schwann cell development; response to lipopolysaccharide; and response to water deprivation. Located in cytosol and nucleus. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 2.0), Muscle (RPKM 0.2) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (24230064..24253219)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (24028716..24047507)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (24653342..24670457)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TFAP2A inhibits microRNA-126 expression at the transcriptional level and aggravates ischemic neuronal injury.
Title: TFAP2A inhibits microRNA-126 expression at the transcriptional level and aggravates ischemic neuronal injury.
SP1 and TFAP2A regulate Gjb2 promoter activity during epididymal differentiation in rat.
Title: Role of Specificity Protein-1 and Activating Protein-2 Transcription Factors in the Regulation of the Gap Junction Protein Beta-2 Gene in the Epididymis of the Rat.
AKT-dependent upregulation of AP-2alpha is essential for carbon monoxide-induced SDF-1alpha expression and myocardial repair after ischemic injury.
Title: Activator protein-2α mediates carbon monoxide-induced stromal cell-derived factor-1α expression and vascularization in ischemic heart.
This study demonistrated that the expression of both subunits varies differently during postnatal development in some areas of rat brain. In striatum, alpha1 can be detected even at early ages, whereas alpha2 is highly expressed on the 15th day after birth.
Title: Expression of coat proteins changes during postnatal development in selected areas of the rat brain.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:516104

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:497491

Tfap2a (e-PCR), detects polymorphism
- UniSTS:547924

AI013304 (e-PCR)
- UniSTS:250222

TFAP2A (e-PCR), detects polymorphism
- UniSTS:279688

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:144558

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:259251

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:536554

Tcfap2a (e-PCR), detects polymorphism
- UniSTS:532464

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables nuclear receptor corepressor activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Schwann cell development	IEP Inferred from Expression Pattern more info	PubMed
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within anterior neuropore closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in bone morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to iron ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to iron ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic body morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic camera-type eye morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic cranial skeleton morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in embryonic forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in embryonic forelimb morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic pattern specification	ISO Inferred from Sequence Orthology more info
acts_upstream_of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within epidermis morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in eyelid development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within face morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of fibroblast migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forebrain neuron development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within forelimb morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in inner ear morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within keratinocyte development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISO Inferred from Sequence Orthology more info
involved_in kidney development	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within lens induction in camera-type eye	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lens morphogenesis in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in metanephric nephron development	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of reactive oxygen species metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by competitive promoter binding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by competitive promoter binding	ISS Inferred from Sequence or Structural Similarity more info
involved_in nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural crest cell development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
acts_upstream_of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve formation	ISO Inferred from Sequence Orthology more info
involved_in oculomotor nerve formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic cup structural organization	ISO Inferred from Sequence Orthology more info
involved_in optic cup structural organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic vesicle morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in optic vesicle morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of bone mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of bone mineralization	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of fibroblast migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tooth mineralization	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tooth mineralization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of neuron differentiation	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info
involved_in retina layer formation	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in roof of mouth development	ISS Inferred from Sequence or Structural Similarity more info
involved_in sensory organ development	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skin development	ISO Inferred from Sequence Orthology more info
involved_in skin development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sympathetic nervous system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	ISO Inferred from Sequence Orthology more info
involved_in trigeminal nerve development	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in clathrin-coated pit	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transcription factor AP-2-alpha

Names: AP-2 transcription factor; AP2-alpha; activating enhancer-binding protein 2-alpha; activator protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107345.3 → NP_001100815.1 transcription factor AP-2-alpha

See identical proteins and their annotated locations for NP_001100815.1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000017

UniProtKB/TrEMBL

A0A8I6AMM5, A6J784, G3V9A8

Related

ENSRNOP00000040925.3, ENSRNOT00000041960.6

Conserved Domains (1) summary

pfam03299
Location:205 → 399

TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

24230064..24253219

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276386.1 → XP_063132456.1 transcription factor AP-2-alpha isoform X3

UniProtKB/TrEMBL

A0A8I6G3W2, A6J782
XM_039095687.2 → XP_038951615.1 transcription factor AP-2-alpha isoform X2

UniProtKB/Swiss-Prot

P58197

UniProtKB/TrEMBL

A0A8I5ZSF0

Related

ENSRNOP00000081532.1

Conserved Domains (1) summary

pfam03299
Location:213 → 407

TF_AP-2; Transcription factor AP-2
XM_063276385.1 → XP_063132455.1 transcription factor AP-2-alpha isoform X1

UniProtKB/TrEMBL

A0A8I6GGS6