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mapk12a mitogen-activated protein kinase 12a [ Danio rerio (zebrafish) ]

Gene ID: 30681, updated on 27-Mar-2024

Summary

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Official Symbol
mapk12aprovided by ZNC
Official Full Name
mitogen-activated protein kinase 12aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990415-257
See related
Ensembl:ENSDARG00000042021 AllianceGenome:ZFIN:ZDB-GENE-990415-257
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
erk6; sapk3; mapk12; fa05c12; wu:fa05c12; zgc:101695; etID309866.18
Summary
Predicted to enable MAP kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including brain; epidermis; otic vesicle; polster; and pronephric duct. Orthologous to human MAPK12 (mitogen-activated protein kinase 12). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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Location:
chromosome: 18
Exon count:
12
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (14845209..14860488, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (14876697..14891976, complement)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene teashirt zinc finger homeobox 3a Neighboring gene MTSS I-BAR domain containing 2a Neighboring gene selenoprotein O1 Neighboring gene TraB domain containing

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Minor class splicing shapes the zebrafish transcriptome during development. Markmiller S, et al. Proc Natl Acad Sci U S A, 2014 Feb 25. PMID 24516132, Free PMC Article
  2. Characterization and expression patterns of the MAPK family in zebrafish. Krens SF, et al. Gene Expr Patterns, 2006 Oct. PMID 16774848
  3. Natural mixtures of POPs affected body weight gain and induced transcription of genes involved in weight regulation and insulin signaling. Lyche JL, et al. Aquat Toxicol, 2011 Apr. PMID 21356182
  4. Natural mixtures of persistent organic pollutants (POP) increase weight gain, advance puberty, and induce changes in gene expression associated with steroid hormones and obesity in female zebrafish. Lyche JL, et al. J Toxicol Environ Health A, 2010. PMID 20526952
  5. In vivo mutation of pre-mRNA processing factor 8 (Prpf8) affects transcript splicing, cell survival and myeloid differentiation. Keightley MC, et al. FEBS Lett, 2013 Jul 11. PMID 23714367, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC101695

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables MAP kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
mitogen-activated protein kinase 12
Names
MAP kinase 12
MAPK 12
extracellular signal-regulated kinase 6
p38-gamma
stress-activated protein kinase 3
NP_571482.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131407.1 → NP_571482.1  mitogen-activated protein kinase 12

    See identical proteins and their annotated locations for NP_571482.1

    Status: PROVISIONAL

    Source sequence(s)
    BC085415
    UniProtKB/Swiss-Prot
    O42376
    UniProtKB/TrEMBL
    Q5U3S2
    Related
    ENSDARP00000011298.8, ENSDART00000018502.9
    Conserved Domains (2) summary
    smart00220
    Location:25 → 309
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:9 → 351
    PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    14845209..14860488 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O42376.1 GenPept UniProtKB/Swiss-Prot:O42376

Gene LinkOut

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