Ror2 receptor tyrosine kinase-like orphan receptor 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ror2provided by RGD
Official Full Name: receptor tyrosine kinase-like orphan receptor 2provided by RGD
Primary source: RGD:1305275
See related: Ensembl:ENSRNOG00000053232 AllianceGenome:RGD:1305275
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable several functions, including Wnt-protein binding activity; frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and positive regulation of protein serine/threonine kinase activity. Located in several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like orphan receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 31.4), Kidney (RPKM 18.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (12124749..12300044)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (11972830..12148152)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (11953552..12134386)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ROR2 homodimerization is sufficient to activate a neuronal Wnt/calcium signaling pathway.
Title: ROR2 homodimerization is sufficient to activate a neuronal Wnt/calcium signaling pathway.
Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats.
Title: Ror2 mediates chronic post-thoracotomy pain by inducing the transformation of A1/A2 reactive astrocytes in rats.
ROR2 regulates dendritic spine morphogenesis through specific protein domains.
Title: The ROR2 tyrosine kinase receptor regulates dendritic spine morphogenesis in hippocampal neurons.
Data show that the receptor tyrosine kinase-like orphan receptor 2 (RoR2) functions as a Wnt5a receptor required to maintain basal NMDA receptors (NMDARs)-mediated synaptic transmission.
Title: RoR2 functions as a noncanonical Wnt receptor that regulates NMDAR-mediated synaptic transmission.
the Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification.
Title: The Wnt5a/Ror2 pathway is associated with determination of the differentiation fate of bone marrow mesenchymal stem cells in vascular calcification.
these results suggest that Wnt5a/Ror2 signaling appears to be involved in BMP-2-mediated osteoblast differentiation in a Smad independent pathway.
Title: Wnt5a signaling is a substantial constituent in bone morphogenetic protein-2-mediated osteoblastogenesis.

Submit: New GeneRIF Correction

General gene information

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Markers

D17Got13 (e-PCR)
- UniSTS:115557

BF389188 (e-PCR)
- UniSTS:245400

BF416265 (e-PCR)
- UniSTS:249249

Ror2 (e-PCR), detects polymorphism
- UniSTS:545980

AU048412 (e-PCR)
- UniSTS:144862

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables Wnt-protein binding	ISO Inferred from Sequence Orthology more info
enables frizzled binding	ISO Inferred from Sequence Orthology more info
enables mitogen-activated protein kinase kinase kinase binding	ISO Inferred from Sequence Orthology more info
enables transmembrane receptor protein tyrosine kinase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within BMP signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within JNK cascade	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in astrocyte development	IDA Inferred from Direct Assay more info	PubMed
involved_in bone mineralization	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cartilage condensation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cell fate commitment	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic digit morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within embryonic genitalia morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in macrophage migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male genitalia development	IEP Inferred from Expression Pattern more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of ERK1 and ERK2 cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of kinase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of macrophage differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of synaptic transmission, glutamatergic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synaptic signaling by nitric oxide	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synaptic signaling by nitric oxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within skeletal system development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within somitogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: tyrosine-protein kinase transmembrane receptor ROR2

NP_001100809.1

EC 2.7.10.1

XP_017455997.1

EC 2.7.10.1

XP_063132415.1

EC 2.7.10.1

XP_063132416.1

EC 2.7.10.1

XP_063132417.1

EC 2.7.10.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107339.1 → NP_001100809.1 tyrosine-protein kinase transmembrane receptor ROR2 precursor

See identical proteins and their annotated locations for NP_001100809.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A0A8I5ZRJ7, A6J6R2, D3ZNY8

Related

ENSRNOP00000069636.1, ENSRNOT00000090782.2

Conserved Domains (6) summary

cd07468
Location:170 → 309

CRD_TK_ROR2; Cysteine-rich domain of tyrosine kinase-like orphan receptor 2

smart00408
Location:75 → 139

IGc2; Immunoglobulin C-2 Type

smart00130
Location:314 → 395

KR; Kringle domain

pfam07679
Location:64 → 152

I-set; Immunoglobulin I-set domain

pfam07714
Location:473 → 746

Pkinase_Tyr; Protein tyrosine kinase

cl21453
Location:466 → 749

PKc_like; Protein Kinases, catalytic domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

12124749..12300044

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063276345.1 → XP_063132415.1 tyrosine-protein kinase transmembrane receptor ROR2 isoform X2
XM_017600508.3 → XP_017455997.1 tyrosine-protein kinase transmembrane receptor ROR2 isoform X1

UniProtKB/TrEMBL

A0A8I5ZRJ7
XM_063276346.1 → XP_063132416.1 tyrosine-protein kinase transmembrane receptor ROR2 isoform X3
XM_063276347.1 → XP_063132417.1 tyrosine-protein kinase transmembrane receptor ROR2 isoform X4