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gsk3ab glycogen synthase kinase 3 alpha b [ Danio rerio (zebrafish) ]

Gene ID: 30664, updated on 11-Apr-2024

Summary

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Official Symbol
gsk3abprovided by ZNC
Official Full Name
glycogen synthase kinase 3 alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-990714-3
See related
Ensembl:ENSDARG00000015681 AllianceGenome:ZFIN:ZDB-GENE-990714-3
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
GSK3; gsk3a; GSK-3[a]; GSK-3[b]
Summary
Predicted to enable protein serine/threonine kinase activity. Acts upstream of or within cardiac muscle cell development; dorsal/ventral pattern formation; and heart looping. Predicted to be active in axon; cytosol; and nucleus. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
chromosome: 16
Exon count:
11
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (11242384..11292151)
105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (11351467..11401249)

Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene capicua transcriptional repressor b Neighboring gene zinc finger protein 526 Neighboring gene zinc finger protein 574 Neighboring gene glutamate receptor, ionotropic, kainate 5 Neighboring gene uncharacterized LOC103908906 Neighboring gene uncharacterized LOC110437971

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. miR-34a Regulates Sperm Motility in Zebrafish. Guo W, et al. Int J Mol Sci, 2017 Dec 10. PMID 29232857, Free PMC Article
  2. Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells. De Servi B, et al. Oncogene, 2005 Jul 21. PMID 15824731
  3. Rumba and Haus3 are essential factors for the maintenance of hematopoietic stem/progenitor cells during zebrafish hematopoiesis. Du L, et al. Development, 2011 Feb. PMID 21228005
  4. Altering PI3K-Akt signalling in zebrafish embryos affects PTEN phosphorylation and gastrulation. Finkielsztein A, et al. Biol Cell, 2009 Aug 25. PMID 19515017
  5. Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo. Lee HC, et al. BMC Dev Biol, 2007 Aug 3. PMID 17683539, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results found gsk3a to be a target for miR-34a which downregulates its expression by targeting its 3' UTR. The miR-34a/gsk3a interaction modulates sperm motility in zebrafish.
    Title: miR-34a Regulates Sperm Motility in Zebrafish.
  2. GSK3alpha, but not GSK3beta, is necessary in cardiomyocyte survival
    Title: Glycogen synthase kinase 3 alpha and 3 beta have distinct functions during cardiogenesis of zebrafish embryo.
  3. lycogen synthase kinase-3 (GSK3) was identified as a substrate of protein kinase c delta in breast cancer cells.
    Title: Impact of PKCdelta on estrogen receptor localization and activity in breast cancer cells.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables tau-protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cardiac muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
  
acts_upstream_of_or_within heart looping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in insulin receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of neuron projection development IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glycogen synthase kinase 3 alpha b; glycogen synthase kinase-3 alpha
NP_571465.1
XP_009290361.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131390.2 → NP_571465.1  glycogen synthase kinase 3 alpha b

    See identical proteins and their annotated locations for NP_571465.1

    Status: PROVISIONAL

    Source sequence(s)
    BC065952
    UniProtKB/TrEMBL
    F6NZ02, Q6NZV8, Q9YH61
    Related
    ENSDARP00000011670.7, ENSDART00000024935.8
    Conserved Domains (1) summary
    cd14137
    Location:78 → 370
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007127.7 Reference GRCz11 Primary Assembly

    Range
    11242384..11292151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009292086.3 → XP_009290361.1  glycogen synthase kinase-3 alpha isoform X1

    UniProtKB/TrEMBL
    A0A8M3AQC2
    Conserved Domains (2) summary
    cd14137
    Location:78 → 370
    STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    pfam00069
    Location:83 → 367
    Pkinase; Protein kinase domain
Nucleotide Protein Strain
Heading Accession and Version

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