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Amt aminomethyltransferase [ Rattus norvegicus (Norway rat) ]

Gene ID: 306586, updated on 13-Apr-2024

Summary

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Official Symbol
Amtprovided by RGD
Official Full Name
aminomethyltransferaseprovided by RGD
Primary source
RGD:1359408
See related
Ensembl:ENSRNOG00000050214 AllianceGenome:RGD:1359408
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable aminomethyltransferase activity. Predicted to be involved in glycine decarboxylation via glycine cleavage system. Predicted to be located in nucleoplasm. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in glycine encephalopathy. Orthologous to human AMT (aminomethyltransferase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 362.2), Liver (RPKM 173.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Amt in Genome Data Viewer
Location:
8q32
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (117859700..117866692)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (108981620..108988127)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (117068388..117078633)

Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene bassoon (presynaptic cytomatrix protein) Neighboring gene dystroglycan 1 Neighboring gene small nuclear ribonucleoprotein D2 polypeptide, pseudogene 3 Neighboring gene nicolin 1, tubulin polyglutamylase complex subunit Neighboring gene U6 snRNA-associated Sm-like protein LSm3 Neighboring gene T-cell leukemia translocation altered Neighboring gene ras homolog family member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Increased activity of renal glycine-cleavage-enzyme complex in metabolic acidosis. Lowry M, et al. Biochem J, 1985 Oct 15. PMID 3877504, Free PMC Article
  2. Crystal structure of human T-protein of glycine cleavage system at 2.0 A resolution and its implication for understanding non-ketotic hyperglycinemia. Okamura-Ikeda K, et al. J Mol Biol, 2005 Sep 2. PMID 16051266
  3. A one-base deletion (183delC) and a missense mutation (D276H) in the T-protein gene from a Japanese family with nonketotic hyperglycinemia. Kure S, et al. J Hum Genet, 1998. PMID 9621520
  4. A missense mutation (His42Arg) in the T-protein gene from a large Israeli-Arab kindred with nonketotic hyperglycinemia. Kure S, et al. Hum Genet, 1998 Apr. PMID 9600239
  5. Identification of the mutations in the T-protein gene causing typical and atypical nonketotic hyperglycinemia. Nanao K, et al. Hum Genet, 1994 Jun. PMID 8005589

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables aminomethyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables transaminase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
involved_in glycine decarboxylation via glycine cleavage system ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
aminomethyltransferase, mitochondrial
Names
aminomethyltransferase (glycine cleavage system protein T)
NP_001014026.1
XP_038937253.1
XP_063121391.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001014004.2 → NP_001014026.1  aminomethyltransferase, mitochondrial

    See identical proteins and their annotated locations for NP_001014026.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000008
    UniProtKB/TrEMBL
    M0R9I6, Q5XI85
    Related
    ENSRNOP00000066155.3, ENSRNOT00000073559.3
    Conserved Domains (3) summary
    PLN02319
    Location:16 → 400
    PLN02319; aminomethyltransferase
    pfam01571
    Location:39 → 291
    GCV_T; Aminomethyltransferase folate-binding domain
    pfam08669
    Location:301 → 392
    GCV_T_C; Glycine cleavage T-protein C-terminal barrel domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086026.1 Reference GRCr8

    Range
    117859700..117866692
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063265321.1 → XP_063121391.1  aminomethyltransferase, mitochondrial isoform X2

  2. XM_039081325.1 → XP_038937253.1  aminomethyltransferase, mitochondrial isoform X1

    UniProtKB/TrEMBL
    A0A8I6A0K6, M0R9I6
    Related
    ENSRNOP00000083744.1, ENSRNOT00000113499.1
    Conserved Domains (1) summary
    cl39066
    Location:16 → 405
    GCV_T; Aminomethyltransferase folate-binding domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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